Disease relevance of TPPP3

• Brain-specific antigens have been observed in the systemic circulation after brain injury [1].
• The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases [2].
• Brain specific gravity and CT scan density measurements after human head injury [3].
• Brain-specific isoforms of ankyrin, 440 kDa and 220 kDa ankyrinB, which are generated from a single gene by alternative splicing of pre-mRNA, are both expressed in human neuroblastoma NB-1 cells and the expression of the larger isoform is increased upon induction of neurite outgrowth [4].
• Brain-specific proteins in demyelination [5].

Psychiatry related information on TPPP3

• Association of Brain-Specific Tryptophan Hydroxylase, TPH2, With Unipolar and Bipolar Disorder in a Northern Swedish, Isolated Population [6].

High impact information on TPPP3

• Brain-specific hyaluronate-binding protein: an immunohistological study with monoclonal antibodies of human and bovine central nervous system [7].
• Brain-specific expression of the human transferrin gene. Similar elements govern transcription in oligodendrocytes and in a neuronal cell line [8].
• Brain-specific receptor-type protein-tyrosine phosphatase RPTP beta is a chondroitin sulfate proteoglycan in vivo [9].
• Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels [10].
• Brain-specific protein C activation during carotid artery occlusion in humans [11].

Anatomical context of TPPP3

• The mammalian KLHL1 is brain-specific, cytosolic and can form multimers and bind actin filaments [12].
• Improved delivery through biological membranes XIV: Brain-specific, sustained delivery of testosterone using a redox chemical delivery system [13].
• Brain-specific proteins in cerebrospinal fluid for the diagnosis of neurodegenerative diseases [14].
• Brain-specific hyaluronate-binding protein. A product of white matter astrocytes [15]?

Associations of TPPP3 with chemical compounds

• Brain-specific chemical delivery systems for beta-lactam antibiotics. Synthesis and properties of some dihydropyridine and dihydroiosquinoline derivatives of benzylpenicillin [16].
• Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats [17].
• Brain specific benzodiazepine receptors [18].
• Brain specific creatine kinase isoenzyme behavior in rat serum after bile acid, sodium oleate and albumin injection [19].

Physical interactions of TPPP3

• Brain-specific interaction of a 91-kDa membrane-bound protein with the cytoplasmic tail of the 300-kDa mannose 6-phosphate receptor [20].

Other interactions of TPPP3

• Brain-specific proteins: solid-phase immunobioluminescence assay for neuron-specific enolase in human plasma [21].
• We report the identification of a cDNA that encodes a putative protein of 94 amino acids and expected molecular weight of 10.7 kDa, the C-terminal half of which is identical to that of PEP19, a small, brain-specific protein involved in Ca++/calmodulin signaling [22].
• Brain-specific expression of a novel human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T9) [23].

References