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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cell Degranulation

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Disease relevance of Cell Degranulation


High impact information on Cell Degranulation


Biological context of Cell Degranulation


Anatomical context of Cell Degranulation


Associations of Cell Degranulation with chemical compounds

  • The PKC inhibitors chlorpromazine and staurosporine inhibited to a significant extent both cell degranulation and all steps leading to paf biosynthesis [10].
  • CONCLUSION: Functional differences in metachromatic cell reactivity are present in atopic subjects 4h after in vivo allergen exposure which relate to the physiological response observed after this time and suggest that there is ongoing metachromatic cell degranulation subjects who subsequently develop LAR [15].
  • Highly purified porcine phospholipase A2 induced noncytotoxic rat cell degranulation, as indicated by release of histamine without release of the cytoplasmic marker lactate dehydrogenase [16].
  • Similar to IgE-mediated cell degranulation we demonstrated inhibition of the c-fos signal in the absence of calcium and after preincubation of cells with the protein tyrosine kinase inhibitor genistein [11].
  • Similarly, MSH cell degranulation is more completely in 5-HTP-treated eels, which show simultaneously an unexplained dilatation of the swim-bladder not elicited by 5-HT treatment [17].

Gene context of Cell Degranulation

  • These include a loss of GLUT2, glycogen accumulation, glucose recycling, abnormal glucokinase or hexokinase, altered mitochondrial glycerol phosphate dehydrogenase (mGPDH) activity, abnormal ion channel function and beta cell degranulation [18].
  • These data suggest that the suppression of cortisol synthesis is responsible for the stimulation of the CRF ir-perikarya and the CRF release along the rostral pars distalis, inducing ACTH cell degranulation [19].
  • Activation of RBL-2H3 cells by short term PMA treatment failed to induce cell degranulation or expression of mRNA for c-fos [11].
  • Anti-OVA antisera with PCA titers of 1/32 to 1/64 failed to stimulate RBL cell degranulation, whereas high titer antibody (1/2048 to 1/4096 by PCA) induced a positive RBL cell response [20].


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  3. Tungstic acid reduction of cold-resistant stress-induced ulceration in rats. Qiu, B.S., Pfeiffer, C.J., Wu, W., Cho, C.H. J. Gastroenterol. Hepatol. (1997) [Pubmed]
  4. Toxicologic evaluation of streptozotocin (NSC 85998) in mice, dogs and monkeys. Levine, B.S., Henry, M.C., Port, C.D., Rosen, E. Drug and chemical toxicology. (1980) [Pubmed]
  5. Modulation of human neutrophil effector functions by monoclonal antibodies against surface membrane molecules of 94,000 and 180,000 molecular weight. King, C.H., Peck, C.A., Haimes, C.S., Kazura, J.W., Spagnuolo, P.J., Sawyer, J.A., Olds, G.R., Mahmoud, A.A. Blood (1986) [Pubmed]
  6. The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency. Hirst, C.E., Buzza, M.S., Bird, C.H., Warren, H.S., Cameron, P.U., Zhang, M., Ashton-Rickardt, P.G., Bird, P.I. J. Immunol. (2003) [Pubmed]
  7. A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes. Sun, J., Bird, C.H., Sutton, V., McDonald, L., Coughlin, P.B., De Jong, T.A., Trapani, J.A., Bird, P.I. J. Biol. Chem. (1996) [Pubmed]
  8. Persistence of tyrosine-phosphorylated FcepsilonRI in deactivated cells. Paolini, R., Serra, A., Kinet, J.P. J. Biol. Chem. (1996) [Pubmed]
  9. Inhibition of 5-lipoxygenase product formation and polymorphonuclear cell degranulation by tenidap sodium in patients with rheumatoid arthritis. Blackburn, W.D., Heck, L.W., Loose, L.D., Eskra, J.D., Carty, T.J. Arthritis Rheum. (1991) [Pubmed]
  10. Biosynthesis of paf-acether. Activators of protein kinase C stimulate cultured mast cell acetyltransferase without stimulating paf-acether synthesis. Joly, F., Vigrain, I., Bossant, M.J., Bessou, G., Benveniste, J., Ninio, E. Biochem. J. (1990) [Pubmed]
  11. Expression of mRNA for the proto-oncogene c-fos in rat basophilic leukaemia cells. Stephan, V., Seibt, A., Körholz, D., Wahn, V. Cell. Signal. (1997) [Pubmed]
  12. Mode of action of tacrolimus (FK506): molecular and cellular mechanisms. Thomson, A.W., Bonham, C.A., Zeevi, A. Therapeutic drug monitoring. (1995) [Pubmed]
  13. In vitro interactions between pulmonary macrophages and respirable particles. Finch, G.L., McNeill, K.L., Hayes, T.L., Fisher, G.L. Environmental research. (1987) [Pubmed]
  14. Monocytes activate eosinophils for enhanced helminthotoxicity and increased generation of leukotriene C4. Elsas, P., Lee, T.H., Lenzi, H.L., Dessein, A.J. Ann. Inst. Pasteur Immunol. (1987) [Pubmed]
  15. Histamine release from bronchoalveolar lavage cells from asthmatic subjects after allergen challenge and relationship to the late asthmatic response. Heaney, L.G., Cross, L.J., Ennis, M. Clin. Exp. Allergy (1998) [Pubmed]
  16. Phospholipase A2-induced rat mast cell secretion. Role of arachidonic acid metabolites. Chi, E.Y., Henderson, W.R., Klebanoff, S.J. Lab. Invest. (1982) [Pubmed]
  17. Effect of serotonin on prolactin- and MSH-secreting cells in the eel. Comparison with the effect of 5-hydroxytryptophan. Olivereau, M., Olivereau, J. Cell Tissue Res. (1979) [Pubmed]
  18. Transcription factor abnormalities as a cause of beta cell dysfunction in diabetes: a hypothesis. Weir, G.C., Sharma, A., Zangen, D.H., Bonner-Weir, S. Acta diabetologica. (1997) [Pubmed]
  19. Responses of brain and pituitary immunoreactive corticotropin-releasing factor in surgically interrenalectomized eels: immunocytochemical study. Olivereau, M., Olivereau, J. Gen. Comp. Endocrinol. (1991) [Pubmed]
  20. Evaluation of an in vitro method for the measurement of specific IgE antibody responses: the rat basophilic leukemia (RBL) cell assay. Dearman, R.J., Skinner, R.A., Deakin, N., Shaw, D., Kimber, I. Toxicology (2005) [Pubmed]
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