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Gene Review

MAGEC1  -  melanoma antigen family C, 1

Homo sapiens

Synonyms: CT7, CT7.1, Cancer/testis antigen 7.1, MAGE-C1, MAGE-C1 antigen, ...
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Disease relevance of MAGEC1


High impact information on MAGEC1

  • Our findings document the immunogenicity of LAGE-1 and CT7 and emphasize the power of serological analysis of cDNA expression libraries in identifying new human tumor antigens [5].
  • The predicted CT7 protein, however, contains a distinct repetitive sequence at the 5' end and is much larger than MAGE proteins [5].
  • Higher levels of CT7 and MAGE-A3/6 proteins also correlated with elevated plasma-cell proliferation [6].
  • Like other MAGE genes, MAGE-C1 is expressed in a significant proportion of tumors of various histological types, whereas it is silent in normal tissues except testis [7].
  • MAGE-C1 is composed of four exons and encodes a putative protein of 1142 amino acids [7].

Biological context of MAGEC1

  • A cDNA fragment sharing significant homology with MAGE genes was identified, and a cosmid containing this new gene, named MAGE-C1, was isolated [7].
  • Comparison of the genomes of BF307, Av-3, and CT7 revealed that their DNAs were similar in size but distinguishable by restriction analysis [8].
  • Chromosome mapping localized CT10 to Xq27, in close proximity to CT7/MAGE-C1 and MAGE-A genes [9].
  • On average, the open reading frames (ORFs) of these 8 closely related genes display a slightly higher degree of nucleotide identity with the MAGE-A ORFs than with the MAGE-B or MAGE-C ORFs [10].
  • The MHD of MAGE-C1 (CT7) was used as bait to screen a human testis cDNA library [11].

Anatomical context of MAGEC1

  • Novel two-parameter flow cytometry (MIL4/SSC followed by MIL4/CT7) allows for identification of five fractions of guinea pig leukocytes in peripheral blood and lymphoid organs [12].
  • Phase changes induced by injections of 8-OH-DPAT at CT7 and triazolam (Tz), a short-acting benzodiazepine, at CT6 were also studied after bilateral chemical lesion of the 5-HT fibres connecting the dorsal raphe nucleus (DR) to IGL [13].
  • We introduce here a new flow cytometric technique (MIL4/SSC followed by MIL4/CT7) which redresses this lack by identifying and characterizing five distinct fractions of PBL: neutrophils, lymphocytes, monocytes, eosinophils plus basophils, and the novel MIL4(-)SSC(large)CT7(high) population [12].
  • CT7 and MAGE-A4 were significantly more frequently expressed in tumors composed of epithelioid cells than spindle cells (p = .05) [14].

Other interactions of MAGEC1


Analytical, diagnostic and therapeutic context of MAGEC1

  • It is probable, therefore, that like other MAGE genes, MAGE-C1 encodes antigens that may constitute useful targets for cancer immunotherapy because of their strict tumoral specificity [7].
  • The following anti-CT monoclonal antibodies/antigens were studied by immunohistochemistry: monoclonal antibody ES121/NY-ESO-1, monoclonal antibody M3H67/MAGE-A3, monoclonal antibody 57B/MAGE-A4, and monoclonal antibody CT7-33/CT7 [16].


  1. CT7 (MAGE-C1) antigen expression in normal and neoplastic tissues. Jungbluth, A.A., Chen, Y.T., Busam, K.J., Coplan, K., Kolb, D., Iversen, K., Williamson, B., Van Landeghem, F.K., Stockert, E., Old, L.J. Int. J. Cancer (2002) [Pubmed]
  2. MAGE-C1 (CT7) gene expression in multiple myeloma: relationship to sperm protein 17. Lim, S.H., Bumm, K., Chiriva-Internati, M., Chiriva-Intemati, M., Xue, Y., Wang, Z. Eur. J. Haematol. (2001) [Pubmed]
  3. Delayed increase in infarct volume after cerebral ischemia: correlations with thrombolytic treatment and clinical outcome. Pantano, P., Caramia, F., Bozzao, L., Dieler, C., von Kummer, R. Stroke (1999) [Pubmed]
  4. Differential expression of cancer testis genes in histological subtypes of non-Hodgkin's lymphomas. Xie, X., Wacker, H.H., Huang, S., Regitz, E., Preuss, K.D., Romeike, B., Parwaresch, R., Tiemann, M., Pfreundschuh, M. Clin. Cancer Res. (2003) [Pubmed]
  5. Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library. Chen, Y.T., Güre, A.O., Tsang, S., Stockert, E., Jäger, E., Knuth, A., Old, L.J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  6. The cancer-testis antigens CT7 (MAGE-C1) and MAGE-A3/6 are commonly expressed in multiple myeloma and correlate with plasma-cell proliferation. Jungbluth, A.A., Ely, S., DiLiberto, M., Niesvizky, R., Williamson, B., Frosina, D., Chen, Y.T., Bhardwaj, N., Chen-Kiang, S., Old, L.J., Cho, H.J. Blood (2005) [Pubmed]
  7. Identification of a new MAGE gene with tumor-specific expression by representational difference analysis. Lucas, S., De Smet, C., Arden, K.C., Viars, C.S., Lethé, B., Lurquin, C., Boon, T. Cancer Res. (1998) [Pubmed]
  8. Use of lytic bacteriophage for Actinomyces viscosus T14V as a probe for cell surface components mediating intergeneric coaggregation. Delisle, A.L., Donkersloot, J.A., Kolenbrander, P.E., Tylenda, C.A. Infect. Immun. (1988) [Pubmed]
  9. CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis. Güre, A.O., Stockert, E., Arden, K.C., Boyer, A.D., Viars, C.S., Scanlan, M.J., Old, L.J., Chen, Y.T. Int. J. Cancer (2000) [Pubmed]
  10. A new family of mouse genes homologous to the human MAGE genes. De Plaen, E., De Backer, O., Arnaud, D., Bonjean, B., Chomez, P., Martelange, V., Avner, P., Baldacci, P., Babinet, C., Hwang, S.Y., Knowles, B., Boon, T. Genomics (1999) [Pubmed]
  11. Physical interaction of two cancer-testis antigens, MAGE-C1 (CT7) and NY-ESO-1 (CT6). Cho, H.J., Caballero, O.L., Gnjatic, S., Andrade, V.C., Colleoni, G.W., Vettore, A.L., Outtz, H.H., Fortunato, S., Altorki, N., Ferrera, C.A., Chua, R., Jungbluth, A.A., Chen, Y.T., Old, L.J., Simpson, A.J. Cancer Immun. (2006) [Pubmed]
  12. Novel two-parameter flow cytometry (MIL4/SSC followed by MIL4/CT7) allows for identification of five fractions of guinea pig leukocytes in peripheral blood and lymphoid organs. Takizawa, M., Chiba, J., Haga, S., Asano, T., Yamazaki, T., Yamamoto, N., Honda, M. J. Immunol. Methods (2006) [Pubmed]
  13. Role of the thalamic intergeniculate leaflet and its 5-HT afferences in the chronobiological properties of 8-OH-DPAT and triazolam in syrian hamster. Schuhler, S., Pitrosky, B., Saboureau, M., Lakhdar-Ghazal, N., Pévet, P. Brain Res. (1999) [Pubmed]
  14. Expression and significance of cancer testis antigens in primary mucosal melanoma of the head and neck. Prasad, M.L., Jungbluth, A.A., Patel, S.G., Iversen, K., Hoshaw-Woodard, S., Busam, K.J. Head & neck. (2004) [Pubmed]
  15. Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues. Langnaese, K., Kloos, D.U., Wehnert, M., Seidel, B., Wieacker, P. Cytogenet. Cell Genet. (2001) [Pubmed]
  16. Expression of cancer-testis antigens in endometrial carcinomas using a tissue microarray. Chitale, D.A., Jungbluth, A.A., Marshall, D.S., Leitao, M.M., Hedvat, C.V., Kolb, D., Spagnoli, G.C., Iversen, K., Soslow, R.A. Mod. Pathol. (2005) [Pubmed]
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