Gene Review:
UGT1A8 - UDP glucuronosyltransferase 1 family,...
Homo sapiens
Synonyms:
GNT1, UDP-glucuronosyltransferase 1-8, UDP-glucuronosyltransferase 1-H, UDP-glucuronosyltransferase 1A8, UDPGT, ...
- Molecular analysis of patients of Sardinian descent with Crigler-Najjar syndrome type I. Rosatelli, M.C., Meloni, A., Faa, V., Saba, L., Crisponi, G., Clemente, M.G., Meloni, G., Piga, M.T., Cao, A. J. Med. Genet. (1997)
- Coinheritance of variant UDP-glucuronosyl transferase 1A1 gene and glucose-6-phosphate dehydrogenase deficiency in adults with hyperbilirubinemia. Huang, M.J., Yang, Y.C., Yang, S.S., Lin, M.S., Chen, E.S., Huang, C.S. Pharmacogenetics (2002)
- Regulation of the human bilirubin UDP-glucuronosyltransferase gene. Brierley, C.H., Senafi, S.B., Clarke, D., Hsu, M.H., Johnson, E.F., Burchell, B. Adv. Enzyme Regul. (1996)
- UDP-glucuronosyltransferases: gene structures of UGT1 and UGT2 families. Owens, I.S., Basu, N.K., Banerjee, R. Meth. Enzymol. (2005)
- Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus. Strassburg, C.P., Strassburg, A., Nguyen, N., Li, Q., Manns, M.P., Tukey, R.H. Biochem. J. (1999)
- Autoantibodies against glucuronosyltransferases differ between viral hepatitis and autoimmune hepatitis. Strassburg, C.P., Obermayer-Straub, P., Alex, B., Durazzo, M., Rizzetto, M., Tukey, R.H., Manns, M.P. Gastroenterology (1996)
- Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone. Thibaudeau, J., Lépine, J., Tojcic, J., Duguay, Y., Pelletier, G., Plante, M., Brisson, J., Têtu, B., Jacob, S., Perusse, L., Bélanger, A., Guillemette, C. Cancer Res. (2006)
- Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. Chen, S., Beaton, D., Nguyen, N., Senekeo-Effenberger, K., Brace-Sinnokrak, E., Argikar, U., Remmel, R.P., Trottier, J., Barbier, O., Ritter, J.K., Tukey, R.H. J. Biol. Chem. (2005)
- Coordinate regulation of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 genes by hepatocyte nuclear factor 1alpha and the caudal-related homeodomain protein 2. Gregory, P.A., Lewinsky, R.H., Gardner-Stephen, D.A., Mackenzie, P.I. Mol. Pharmacol. (2004)
- Cloning and characterization of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 gene promoters: differential regulation through an interior-like region. Gregory, P.A., Gardner-Stephen, D.A., Lewinsky, R.H., Duncliffe, K.N., Mackenzie, P.I. J. Biol. Chem. (2003)
- Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4alpha. Barbier, O., Girard, H., Inoue, Y., Duez, H., Villeneuve, L., Kamiya, A., Fruchart, J.C., Guillemette, C., Gonzalez, F.J., Staels, B. Mol. Pharmacol. (2005)
- Hepatocyte nuclear factor1 transcription factors are essential for the UDP-glucuronosyltransferase 1A9 promoter response to hepatocyte nuclear factor 4alpha. Gardner-Stephen, D.A., Mackenzie, P.I. Pharmacogenet. Genomics (2007)
- Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3. Huang, Y.H., Galijatovic, A., Nguyen, N., Geske, D., Beaton, D., Green, J., Green, M., Peters, W.H., Tukey, R.H. Pharmacogenetics (2002)
- Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Watanabe, Y., Nakajima, M., Yokoi, T. Drug Metab. Dispos. (2002)
- Amino acid residue ILE211 is essential for the enzymatic activity of human UDP-glucuronosyltransferase 1A10 (UGT1A10). Martineau, I., Tchernof, A., Bélanger, A. Drug Metab. Dispos. (2004)
- Characterization of raloxifene glucuronidation in vitro: contribution of intestinal metabolism to presystemic clearance. Kemp, D.C., Fan, P.W., Stevens, J.C. Drug Metab. Dispos. (2002)
- Regulation of UDP glucuronosyltransferases in the gastrointestinal tract. Gregory, P.A., Lewinsky, R.H., Gardner-Stephen, D.A., Mackenzie, P.I. Toxicol. Appl. Pharmacol. (2004)
- Involvement of multiple UDP-glucuronosyltransferase 1A isoforms in glucuronidation of 5-(4'-hydroxyphenyl)-5-phenylhydantoin in human liver microsomes. Nakajima, M., Sakata, N., Ohashi, N., Kume, T., Yokoi, T. Drug Metab. Dispos. (2002)
- Identification of uridine diphosphate glucuronosyltransferases involved in the metabolism and clearance of mycophenolic acid. Mackenzie, P.I. Therapeutic drug monitoring. (2000)
- Kinetic characterization of the 1A subfamily of recombinant human UDP-glucuronosyltransferases. Luukkanen, L., Taskinen, J., Kurkela, M., Kostiainen, R., Hirvonen, J., Finel, M. Drug Metab. Dispos. (2005)
- Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. Strassburg, C.P., Manns, M.P., Tukey, R.H. J. Biol. Chem. (1998)
- Identification of UDP-glucuronosyltransferases involved in the human hepatic metabolism of GV150526, a novel glycine antagonist. Gilissen, R.A., Barnaby, R.J., Kajbaf, M. Drug metabolism and drug interactions. (2000)
- Influence of nonsynonymous polymorphisms of UGT1A8 and UGT2B7 metabolizing enzymes on the formation of phenolic and acyl glucuronides of mycophenolic acid. Bernard, O., Tojcic, J., Journault, K., Perusse, L., Guillemette, C. Drug Metab. Dispos. (2006)
- Cloning and expression of human UDP-glucuronosyltransferase (UGT) 1A8. Cheng, Z., Radominska-Pandya, A., Tephly, T.R. Arch. Biochem. Biophys. (1998)
- Genetic defects at the UGT1 locus associated with Crigler-Najjar type I disease, including a prenatal diagnosis. Ciotti, M., Obaray, R., Martín, M.G., Owens, I.S. Am. J. Med. Genet. (1997)
- Expression of the human UDP-galactose transporter in the Golgi membranes of murine Had-1 cells that lack the endogenous transporter. Yoshioka, S., Sun-Wada, G.H., Ishida, N., Kawakita, M. J. Biochem. (1997)