Gene Review:
UGT1A7 - UDP glucuronosyltransferase 1 family,...
Homo sapiens
Synonyms:
GNT1, UDP-glucuronosyltransferase 1-7, UDP-glucuronosyltransferase 1-G, UDP-glucuronosyltransferase 1A7, UDPGT, ...
- Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus. Strassburg, C.P., Strassburg, A., Nguyen, N., Li, Q., Manns, M.P., Tukey, R.H. Biochem. J. (1999)
- Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese. Huang, M.J., Yang, S.S., Lin, M.S., Huang, C.S. World J. Gastroenterol. (2005)
- Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene. Vogel, A., Kneip, S., Barut, A., Ehmer, U., Tukey, R.H., Manns, M.P., Strassburg, C.P. Gastroenterology (2001)
- UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. Carlini, L.E., Meropol, N.J., Bever, J., Andria, M.L., Hill, T., Gold, P., Rogatko, A., Wang, H., Blanchard, R.L. Clin. Cancer Res. (2005)
- UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma risk and onset age. Tseng, C.S., Tang, K.S., Lo, H.W., Ker, C.G., Teng, H.C., Huang, C.S. Am. J. Gastroenterol. (2005)
- Genetic polymorphisms of the uridine diphosphate glucuronosyltransferase 1A7 and colorectal cancer risk in relation to cigarette smoking and alcohol drinking in a Chinese population. Chen, K., Jin, M., Zhu, Y., Jiang, Q., Yu, W., Ma, X., Yao, K. J. Gastroenterol. Hepatol. (2006)
- Tobacco carcinogen-detoxifying enzyme UGT1A7 and its association with orolaryngeal cancer risk. Zheng, Z., Park, J.Y., Guillemette, C., Schantz, S.P., Lazarus, P. J. Natl. Cancer Inst. (2001)
- UDP glucuronosyltransferase (UGT1A7) gene polymorphisms increase the risk of chronic pancreatitis and pancreatic cancer. Ockenga, J., Vogel, A., Teich, N., Keim, V., Manns, M.P., Strassburg, C.P. Gastroenterology (2003)
- Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin. Han, J.Y., Lim, H.S., Shin, E.S., Yoo, Y.K., Park, Y.H., Lee, J.E., Jang, I.J., Lee, D.H., Lee, J.S. J. Clin. Oncol. (2006)
- Molecular analysis of patients of Sardinian descent with Crigler-Najjar syndrome type I. Rosatelli, M.C., Meloni, A., Faa, V., Saba, L., Crisponi, G., Clemente, M.G., Meloni, G., Piga, M.T., Cao, A. J. Med. Genet. (1997)
- Regulation of the human bilirubin UDP-glucuronosyltransferase gene. Brierley, C.H., Senafi, S.B., Clarke, D., Hsu, M.H., Johnson, E.F., Burchell, B. Adv. Enzyme Regul. (1996)
- Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation. Basu, N.K., Kubota, S., Meselhy, M.R., Ciotti, M., Chowdhury, B., Hartori, M., Owens, I.S. J. Biol. Chem. (2004)
- Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene. Lankisch, T.O., Vogel, A., Eilermann, S., Fiebeler, A., Krone, B., Barut, A., Manns, M.P., Strassburg, C.P. Mol. Pharmacol. (2005)
- Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk. van der Logt, E.M., Bergevoet, S.M., Roelofs, H.M., van Hooijdonk, Z., te Morsche, R.H., Wobbes, T., de Kok, J.B., Nagengast, F.M., Peters, W.H. Carcinogenesis (2004)
- Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients. Jinno, H., Saeki, M., Saito, Y., Tanaka-Kagawa, T., Hanioka, N., Sai, K., Kaniwa, N., Ando, M., Shirao, K., Minami, H., Ohtsu, A., Yoshida, T., Saijo, N., Ozawa, S., Sawada, J. J. Pharmacol. Exp. Ther. (2003)
- Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium. Strassburg, C.P., Nguyen, N., Manns, M.P., Tukey, R.H. Mol. Pharmacol. (1998)
- Amino acid residue ILE211 is essential for the enzymatic activity of human UDP-glucuronosyltransferase 1A10 (UGT1A10). Martineau, I., Tchernof, A., Bélanger, A. Drug Metab. Dispos. (2004)
- Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues. Zheng, Z., Fang, J.L., Lazarus, P. Drug Metab. Dispos. (2002)
- Regulation of UDP glucuronosyltransferases in the gastrointestinal tract. Gregory, P.A., Lewinsky, R.H., Gardner-Stephen, D.A., Mackenzie, P.I. Toxicol. Appl. Pharmacol. (2004)
- Characterization of rabbit UDP-glucuronosyltransferase UGT1A7: tertiary amine glucuronidation is catalyzed by UGT1A7 and UGT1A4. Bruck, M., Li, Q., Lamb, J.G., Tukey, R.H. Arch. Biochem. Biophys. (1997)
- UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects. Bock, K.W., Köhle, C. Meth. Enzymol. (2005)
- Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs. Villeneuve, L., Girard, H., Fortier, L.C., Gagné, J.F., Guillemette, C. J. Pharmacol. Exp. Ther. (2003)
- Glucuronidation of 1-hydroxypyrene by human liver microsomes and human UDP-glucuronosyltransferases UGT1A6, UGT1A7, and UGT1A9: development of a high-sensitivity glucuronidation assay for human tissue. Luukkanen, L., Mikkola, J., Forsman, T., Taavitsainen, P., Taskinen, J., Elovaara, E. Drug Metab. Dispos. (2001)
- Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity. Basu, N.K., Kovarova, M., Garza, A., Kubota, S., Saha, T., Mitra, P.S., Banerjee, R., Rivera, J., Owens, I.S. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Involvement of hepatocyte nuclear factor 1 in the regulation of the UDP-glucuronosyltransferase 1A7 (UGT1A7) gene in rat hepatocytes. Metz, R.P., Auyeung, D.J., Kessler, F.K., Ritter, J.K. Mol. Pharmacol. (2000)
- Characterization of benzo(a)pyrene-trans-7,8-dihydrodiol glucuronidation by human tissue microsomes and overexpressed UDP-glucuronosyltransferase enzymes. Fang, J.L., Beland, F.A., Doerge, D.R., Wiener, D., Guillemette, C., Marques, M.M., Lazarus, P. Cancer Res. (2002)
- Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. Strassburg, C.P., Manns, M.P., Tukey, R.H. J. Biol. Chem. (1998)
- Characterization of the UDP-glucuronosyltransferase 1A locus in lagomorphs: evidence for duplication of the UGT1A6 gene. Li, Q., Lamb, G., Tukey, R.H. Mol. Pharmacol. (2000)
- UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma in japanese patients with hepatitis C virus infection. Wang, Y., Kato, N., Hoshida, Y., Otsuka, M., Taniguchi, H., Moriyama, M., Shiina, S., Kawabe, T., Ito, Y.M., Omata, M. Clin. Cancer Res. (2004)
- Joint effects between UDP-glucuronosyltransferase 1A7 genotype and dietary carcinogen exposure on risk of colon cancer. Butler, L.M., Duguay, Y., Millikan, R.C., Sinha, R., Gagné, J.F., Sandler, R.S., Guillemette, C. Cancer Epidemiol. Biomarkers Prev. (2005)
- Genetic polymorphisms of the UDP-glucuronosyltransferase 1A7 gene and irinotecan toxicity in Japanese cancer patients. Ando, M., Ando, Y., Sekido, Y., Ando, M., Shimokata, K., Hasegawa, Y. Jpn. J. Cancer Res. (2002)
- Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Miles, K.K., Kessler, F.K., Smith, P.C., Ritter, J.K. Drug Metab. Dispos. (2006)
- Therapeutic lentivirus-mediated neonatal in vivo gene therapy in hyperbilirubinemic Gunn rats. Nguyen, T.H., Bellodi-Privato, M., Aubert, D., Pichard, V., Myara, A., Trono, D., Ferry, N. Mol. Ther. (2005)