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PSMC6  -  proteasome (prosome, macropain) 26S...

Homo sapiens

Synonyms: 26S protease regulatory subunit 10B, 26S proteasome AAA-ATPase subunit RPT4, CADP44, HEL-S-73, P44, ...
 
 
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Disease relevance of PSMC6

  • Chemotaxis involved signaling via both receptors, and a pertussis toxin-sensitive p42/p44 mitogen-activated protein kinase (MAPK)-mediated pathway that could be inhibited by MAPK kinase (MEK)1/2 antagonists [1].
  • RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation [2].
  • Furthermore, in cells stably transfected with human catalase, angiotensin II-induced intracellular H2O2 generation is almost completely blocked, resulting in inhibition of phosphorylation of p38MAPK, but not p42/44MAPK, and a subsequent partial decrease in angiotensin II-induced hypertrophy [3].
  • Structure of the Expression Site Reveals Global Diversity in MSP2 (P44) Variants in Anaplasma phagocytophilum [4].
  • Expression of interleukin-1beta, tumor necrosis factor alpha, and interleukin-6 in human peripheral blood leukocytes exposed to human granulocytic ehrlichiosis agent or recombinant major surface protein P44 [5].
 

Psychiatry related information on PSMC6

  • For the octachlorinated toxaphene congeners (Parlar-26 (P-26), Parlar-40/41 (P-40/41), Parlar-44 (P-44)), the detection performance of the ion trap MS/MS is similar whether Ip and Id were chosen at low or high m/z ratios [6].
 

High impact information on PSMC6

  • Activation of chemerin receptor results in intracellular calcium release, inhibition of cAMP accumulation, and phosphorylation of p42-p44 MAP kinases, through the Gi class of heterotrimeric G proteins [7].
  • Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry [8].
  • Overexpression of p48 provokes cell proliferation, which is inhibited by p42 [9].
  • The longer-form p48 localizes in both the cytoplasm and the nucleus and suppresses apoptosis, whereas the shorter-form p42 predominantly resides in the cytoplasm and promotes cell differentiation [9].
  • Moreover, nerve growth factor elicits extensive sprouting in p42 stably transfected PC12 cells, whereas p48 cells reveal modest neurite outgrowth [9].
 

Chemical compound and disease context of PSMC6

  • A novel strain, Origami(DE3), of Escherichia coli with mutations in the glutathione and thioredoxin reductase genes yielded 60% more soluble PvMSP-1 p42 than the conventional E. coli BL21(DE3) strain [10].
 

Biological context of PSMC6

  • Amino acid sequence analysis of the subunits shows that p50 and p42 are members of the same ATP-binding protein family found in PA700 [11].
  • Computer analysis reveals that p42 is a novel member of a large protein family characterized by a conserved 200 amino acid domain which contains a consensus sequence for ATP binding [12].
  • After 4 h of labeling, the endocrine cells exhibited a sevenfold higher phosphorylation of p42 than the duct cells, whereas p45 was phosphorylated only in endocrine cells [13].
  • We demonstrate the utility of this methodology by identifying the Rpt6/Sug1 and Rpt4/Sug2 proteins as the direct targets of transcriptional activation domains in the 26S proteasome [14].
  • Thus, Ebp1 might regulate cell survival and differentiation through two distinctive p48 and p42 isoforms [9].
 

Anatomical context of PSMC6

  • Gel filtration chromatography was employed to determine the qualitative and quantitative distribution of p42 in crude soluble lysates of bovine red blood cells [12].
  • After isolation and culture, both duct and islet cell preparations contained the Ipf-1 immunoreactive proteins p42 and p45 (42 and 45 kDa, respectively) in similar proportions, but the expression levels were twofold lower in duct cells [13].
  • Here, we show that Ebp1 possesses two different isoforms, p48 and p42, which differentially mediate PC12 cell survival and differentiation [9].
  • Differentiation induction and proliferation inhibition were required for optimal suppression of leukemogenesis, as indicated by the effects of p42 C/EBPalpha, which were more potent than those of K298E C/EBPalpha, a mutant defective in DNA binding and transcription activation that failed to induce granulocyte differentiation [15].
  • We observed that SLPs increased calcium flux, phosphorylation of mitogen-activated protein kinase (MAPK) p42/44 and AKT, secretion of matrix metalloproteinases, and adhesion to endothelium in CD34+ cells [16].
 

Associations of PSMC6 with chemical compounds

  • Coadministration of a nontoxic concentration of the MEK1/2 inhibitor PD184352 (5 microM) prevented STI571-mediated activation of p42/44 MAPK [17].
  • We show here that angiotensin II elicits a rapid increase in intracellular H2O2 and a rapid and robust phosphorylation of both p42/44MAPK (16-fold) and p38MAPK (15-fold) [3].
  • Ouabain caused rapid activations of Ras and p42/44 MAPKs; the latter was sustained longer than 90 min [18].
  • Furthermore, adding H-89, an inhibitor of protein kinase A, or Rp-8-Br-cAMP-S, an inactive cAMP analog, failed to impair p42/p44(mapk) activity and neurite outgrowth induced by Ang II [19].
  • In vitro phosphorylation assays with point-mutated P44-derived peptides suggested that serine 347 of SMAR1 was indispensable for its activity and represented the substrate motif for the protein kinase C family of proteins [20].
 

Other interactions of PSMC6

  • Activator complexes containing the proteasomal regulatory ATPases S10b (SUG2) and S6 (TBP1) in different tissues and organisms [21].
  • The modulator has a native Mr of approximately 300,000, as determined by gel filtration chromatography, and is composed of three electrophoretically distinct subunits with Mr values of 50,000, 42,000, and 27,000 (p50, p42, and p27, respectively) [11].
  • Interestingly, the basal levels of phosphatidylinositol 3-kinase, Akt/protein kinase B, and p42/p44 MAPK activation were unchanged in LAMD-SM and ELT3 cells relative to levels in normal human tracheal and vascular SM [22].
  • There were no changes in content of subunits of 20S proteasomes or 19S regulator ATPase subunits S4 and p42 by AA/Fe-NTA treatment [23].
 

Analytical, diagnostic and therapeutic context of PSMC6

  • Western blot analysis revealed that sHA treatment resulted in distinct phosphorylation of p38/p42/44 MAP-kinases and nuclear translocation of nuclear factor (NF)-kappa B, all components of the TLR-4 signaling pathway [24].
  • Using xenograft nude mice models, we further demonstrate that P44 was capable of inhibiting tumor growth by preventing cellular proliferation [20].
  • The Kasumi-6 cells expressed both the p42 and p30 isoforms of the C/EBPalpha protein endogenously, but electrophoretic mobility shift assays demonstrated an absence of C/EBPalpha binding to its respective site [25].
  • Hypothermia-induced loss of endothelial barrier function is restored after dopamine pretreatment: role of p42/p44 activation [26].
  • Only in dopamine treated Lewis renal allografts subjected to cold storage, activation of p42/p44 occurred upon rewarming [26].

References

  1. A role for endothelin-2 and its receptors in breast tumor cell invasion. Grimshaw, M.J., Hagemann, T., Ayhan, A., Gillett, C.E., Binder, C., Balkwill, F.R. Cancer Res. (2004) [Pubmed]
  2. RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. Fromigu??, O., Ha??, E., Modrowski, D., Bouvet, S., Jacquel, A., Auberger, P., Marie, P.J. Cell Death Differ. (2006) [Pubmed]
  3. p38 Mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II. Role in vascular smooth muscle cell hypertrophy. Ushio-Fukai, M., Alexander, R.W., Akers, M., Griendling, K.K. J. Biol. Chem. (1998) [Pubmed]
  4. Structure of the Expression Site Reveals Global Diversity in MSP2 (P44) Variants in Anaplasma phagocytophilum. Barbet, A.F., Lundgren, A.M., Alleman, A.R., Stuen, S., Bj??ersdorff, A., Brown, R.N., Drazenovich, N.L., Foley, J.E. Infect. Immun. (2006) [Pubmed]
  5. Expression of interleukin-1beta, tumor necrosis factor alpha, and interleukin-6 in human peripheral blood leukocytes exposed to human granulocytic ehrlichiosis agent or recombinant major surface protein P44. Kim, H.Y., Rikihisa, Y. Infect. Immun. (2000) [Pubmed]
  6. Analysis of six relevant toxaphene congeners in biological samples using ion trap MS/MS. Gouteux, B., Lebeuf, M., Trottier, S., Gagné, J.P. Chemosphere (2002) [Pubmed]
  7. Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. Wittamer, V., Franssen, J.D., Vulcano, M., Mirjolet, J.F., Le Poul, E., Migeotte, I., Brézillon, S., Tyldesley, R., Blanpain, C., Detheux, M., Mantovani, A., Sozzani, S., Vassart, G., Parmentier, M., Communi, D. J. Exp. Med. (2003) [Pubmed]
  8. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. Brunet, A., Roux, D., Lenormand, P., Dowd, S., Keyse, S., Pouysségur, J. EMBO J. (1999) [Pubmed]
  9. Ebp1 isoforms distinctively regulate cell survival and differentiation. Liu, Z., Ahn, J.Y., Liu, X., Ye, K. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  10. Purification, characterization, and immunogenicity of a disulfide cross-linked Plasmodium vivax vaccine candidate antigen, merozoite surface protein 1, expressed in Escherichia coli. Dutta, S., Ware, L.A., Barbosa, A., Ockenhouse, C.F., Lanar, D.E. Infect. Immun. (2001) [Pubmed]
  11. Identification, purification, and characterization of a PA700-dependent activator of the proteasome. DeMartino, G.N., Proske, R.J., Moomaw, C.R., Strong, A.A., Song, X., Hisamatsu, H., Tanaka, K., Slaughter, C.A. J. Biol. Chem. (1996) [Pubmed]
  12. cDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family. Fujiwara, T., Watanabe, T.K., Tanaka, K., Slaughter, C.A., DeMartino, G.N. FEBS Lett. (1996) [Pubmed]
  13. Adult human pancreatic duct and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein Ipf-1. Heimberg, H., Bouwens, L., Heremans, Y., Van De Casteele, M., Lefebvre, V., Pipeleers, D. Diabetes (2000) [Pubmed]
  14. Identification of Gal4 activation domain-binding proteins in the 26S proteasome by periodate-triggered cross-linking. Archer, C.T., Burdine, L., Kodadek, T. Molecular bioSystems. (2005) [Pubmed]
  15. Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBPalpha. Ferrari-Amorotti, G., Keeshan, K., Zattoni, M., Guerzoni, C., Iotti, G., Cattelani, S., Donato, N.J., Calabretta, B. Blood (2006) [Pubmed]
  16. Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient. Wysoczynski, M., Reca, R., Ratajczak, J., Kucia, M., Shirvaikar, N., Honczarenko, M., Mills, M., Wanzeck, J., Janowska-Wieczorek, A., Ratajczak, M.Z. Blood (2005) [Pubmed]
  17. Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells. Yu, C., Krystal, G., Varticovksi, L., McKinstry, R., Rahmani, M., Dent, P., Grant, S. Cancer Res. (2002) [Pubmed]
  18. Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases. Kometiani, P., Li, J., Gnudi, L., Kahn, B.B., Askari, A., Xie, Z. J. Biol. Chem. (1998) [Pubmed]
  19. Cyclic AMP-independent involvement of Rap1/B-Raf in the angiotensin II AT2 receptor signaling pathway in NG108-15 cells. Gendron, L., Oligny, J.F., Payet, M.D., Gallo-Payet, N. J. Biol. Chem. (2003) [Pubmed]
  20. SMAR1-derived P44 Peptide Retains Its Tumor Suppressor Function through Modulation of p53. Jalota-Badhwar, A., Kaul-Ghanekar, R., Mogare, D., Boppana, R., Paknikar, K.M., Chattopadhyay, S. J. Biol. Chem. (2007) [Pubmed]
  21. Activator complexes containing the proteasomal regulatory ATPases S10b (SUG2) and S6 (TBP1) in different tissues and organisms. Hastings, R., Walker, G., Eyheralde, I., Dawson, S., Billett, M., Mayer, R.J. Mol. Biol. Rep. (1999) [Pubmed]
  22. Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). Goncharova, E.A., Goncharov, D.A., Eszterhas, A., Hunter, D.S., Glassberg, M.K., Yeung, R.S., Walker, C.L., Noonan, D., Kwiatkowski, D.J., Chou, M.M., Panettieri, R.A., Krymskaya, V.P. J. Biol. Chem. (2002) [Pubmed]
  23. The effect of CYP2E1-dependent oxidant stress on activity of proteasomes in HepG2 cells. Kessova, I.G., Cederbaum, A.I. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  24. Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. Termeer, C., Benedix, F., Sleeman, J., Fieber, C., Voith, U., Ahrens, T., Miyake, K., Freudenberg, M., Galanos, C., Simon, J.C. J. Exp. Med. (2002) [Pubmed]
  25. Establishment of the acute myeloid leukemia cell line Kasumi-6 from a patient with a dominant-negative mutation in the DNA-binding region of the C/EBPalpha gene. Asou, H., Gombart, A.F., Takeuchi, S., Tanaka, H., Tanioka, M., Matsui, H., Kimura, A., Inaba, T., Koeffler, H.P. Genes Chromosomes Cancer (2003) [Pubmed]
  26. Hypothermia-induced loss of endothelial barrier function is restored after dopamine pretreatment: role of p42/p44 activation. Brinkkoetter, P.T., Beck, G.C., Gottmann, U., Loesel, R., Schnetzke, U., Rudic, B., Hanusch, C., Rafat, N., Liu, Z., Weiss, C., Leuvinik, H.G., Ploeg, R., Braun, C., Schnuelle, P., van der Woude, F.J., Yard, B.A. Transplantation (2006) [Pubmed]
 
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