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Gene Review

Hist1h2bl  -  histone cluster 1, H2bl

Rattus norvegicus

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Disease relevance of Hist1h2bl


High impact information on Hist1h2bl

  • These receptors also showed diminished exogenous substrate kinase activity using histone H2b and angiotensin II as phosphoacceptors [2].
  • In contrast to the latter enzyme, this new enzyme catalyzed the spliting of a linkage between ADP-ribose and a protein portion in mono ADP-ribosylated histone H2B but little, if any, of the glycosidic ribosyl(1"-2') ribose bonds within poly(ADP-ribose) [3].
  • Histone H2B phosphorylation in mammalian apoptotic cells. An association with DNA fragmentation [4].
  • Cardiolipin activation was most evident with autophosphorylation and histone H2B phosphorylation, but only marginally evident with the favored ribosomal S6-(229-239) peptide substrate for the protease-activated kinase activity [5].
  • Insulin receptor tyrosine kinase activity solubilized from hind limb muscle of control and streptozocin-induced diabetic (STZ-D) rats (2-3 wk) was studied with the substrates histone H2B and poly glutamic acid-tyrosine (glu-tyr) (4:1) [6].

Biological context of Hist1h2bl


Anatomical context of Hist1h2bl


Associations of Hist1h2bl with chemical compounds


Regulatory relationships of Hist1h2bl


Other interactions of Hist1h2bl

  • Calmodulin also induced an approximately 2-fold increase in both the rate and amount of insulin-mediated incorporation of 32P into histone H2b [19].
  • Phosphorylation of substrates currently used for protein kinase assays (histone H2B and phosvitin) was not stimulated [20].
  • To explore the relationship between postnatal renal development and the renin-angiotensin system, we examined the steady-state levels of messenger ribonucleic acid (mRNA) for renin, angiotensinogen, histone H2b (a marker of DNA synthesis) and the structural protein actin [21].
  • Additionally, the gel reveals two protein bands, one ahead of histone H2B and another ahead of histone H4, that are diminished or missing from the inactive chromatin [22].

Analytical, diagnostic and therapeutic context of Hist1h2bl

  • Autophosphorylation of the beta-subunit and receptor tyrosyl kinase activity toward histone H2b was stimulated by insulin in denervated muscles as in controls, although the biological response to insulin, in vitro and in vivo, was markedly impaired after denervation, suggesting a postreceptor defect [23].
  • The genomic and sequence analysis of rat histone H2B genes [24].
  • Isolation, purification, tryptic digestion, and peptide sequence analysis of the retinal approximately 20 kDa phosphoprotein suggest that it is histone H2B [25].


  1. ADP-ribosylation of nuclear proteins in vivo. Identification of histone H2B as a major acceptor for mono- and poly(ADP-ribose) in dimethyl sulfate-treated hepatoma AH 7974 cells. Adamietz, P., Rudolph, A. J. Biol. Chem. (1984) [Pubmed]
  2. Diabetes-induced functional and structural changes in insulin receptors from rat skeletal muscle. Burant, C.F., Treutelaar, M.K., Buse, M.G. J. Clin. Invest. (1986) [Pubmed]
  3. Novel enzyme from rat liver that cleaves an ADP-ribosyl histone linkage. Okayama, H., Honda, M., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  4. Histone H2B phosphorylation in mammalian apoptotic cells. An association with DNA fragmentation. Ajiro, K. J. Biol. Chem. (2000) [Pubmed]
  5. Isolation and characterization of a structural homologue of human PRK2 from rat liver. Distinguishing substrate and lipid activator specificities. Yu, W., Liu, J., Morrice, N.A., Wettenhall, R.E. J. Biol. Chem. (1997) [Pubmed]
  6. Skeletal muscle insulin-receptor kinase. Effects of substrate inhibition and diabetes. Block, N.E., Komori, K., Dutton, S.L., Robinson, K.A., Buse, M.G. Diabetes (1991) [Pubmed]
  7. P1,P4-Di(adenosine-5')tetraphosphate inhibits phosphorylation of immunoglobulin G by Rous sarcoma virus pp60src. Maness, P.F., Perry, M.E., Levy, B.T. J. Biol. Chem. (1983) [Pubmed]
  8. The major subacrosomal occupant of bull spermatozoa is a novel histone H2B variant associated with the forming acrosome during spermiogenesis. Aul, R.B., Oko, R.J. Dev. Biol. (2001) [Pubmed]
  9. Acetylation of rat testis histones H2B and TH2B. Grimes, S.R., Henderson, N. Dev. Biol. (1984) [Pubmed]
  10. Amino acid sequence of rat thymus histone H2B and identification of the in vitro phosphorylation sites. Martinage, A., Mangeat, P., Sautière, P., Marchis-Mouren, G., Biserte, G. Biochimie (1979) [Pubmed]
  11. Poly(ADP-ribose) accessibility to poly(ADP-ribose) glycohydrolase activity on poly(ADP-ribosyl)ated nucleosomal proteins. Gaudreau, A., Ménard, L., de Murcia, G., Poirier, G.G. Biochem. Cell Biol. (1986) [Pubmed]
  12. The major subacrosomal occupant of bull spermatozoa is a novel histone H2B variant associated with the forming acrosome during spermiogenesis. Aul, R.B., Oko, R.J. Dev. Biol. (2002) [Pubmed]
  13. Truncation, deamidation, and oxidation of histone H2B in cells cultured with nickel(II). Karaczyn, A.A., Golebiowski, F., Kasprzak, K.S. Chem. Res. Toxicol. (2005) [Pubmed]
  14. The carboxyl terminal segment of the c-Ki-ras 2 gene product mediates insulin-stimulated phosphorylation of calmodulin and stimulates insulin-independent autophosphorylation of the insulin receptor. Sacks, D.B., Glenn, K.C., McDonald, J.M. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  15. A novel mechanism for the insulin-like effect of vanadate on glycogen synthase in rat adipocytes. Tamura, S., Brown, T.A., Whipple, J.H., Fujita-Yamaguchi, Y., Dubler, R.E., Cheng, K., Larner, J. J. Biol. Chem. (1984) [Pubmed]
  16. ADP-ribosylation of histone H2B. Identification of glutamic acid residue 2 as the modification site. Ogata, N., Ueda, K., Hayaishi, O. J. Biol. Chem. (1980) [Pubmed]
  17. Gonadotrophin-releasing activity of histones H2A and H2B. Brown, O.A., Sosa, Y., Goya, R.G. Cell. Mol. Life Sci. (1998) [Pubmed]
  18. Diabetes-associated impairment of hepatic insulin receptor tyrosine kinase activity: a study of mechanisms. Block, N.E., Komori, K., Robinson, K.A., Dutton, S.L., Lam, C.F., Buse, M.G. Endocrinology (1991) [Pubmed]
  19. The insulin receptor and calmodulin. Calmodulin enhances insulin-mediated receptor kinase activity and insulin stimulates phosphorylation of calmodulin. Graves, C.B., Gale, R.D., Laurino, J.P., McDonald, J.M. J. Biol. Chem. (1986) [Pubmed]
  20. Activation of S6 kinase activity in astrocytes by insulin, somatomedin C and TPA. Pierre, M., Toru-Delbauffe, D., Gavaret, J.M., Pomerance, M., Jacquemin, C. FEBS Lett. (1986) [Pubmed]
  21. Relationship between renin, angiotensinogen and histone H2b messenger ribonucleic acid in the maturing rat kidney. Correa-Rotter, R., Pérez-Castillo, A., Chmielewski, D., Rosenberg, M.E. Nephron (1992) [Pubmed]
  22. Studies on the isolated transcriptionally active and inactive chromatin fractions from rat liver nuclei. Yu, F.L., Bender, W. J. Biochem. Biophys. Methods (1995) [Pubmed]
  23. In vitro and in vivo activation of the insulin receptor kinase in control and denervated skeletal muscle. Burant, C.F., Treutelaar, M.K., Buse, M.G. J. Biol. Chem. (1986) [Pubmed]
  24. The genomic and sequence analysis of rat histone H2B genes. Choi, Y.C., Chae, C.B. DNA Seq. (1998) [Pubmed]
  25. Increased phosphorylation of specific rat cardiac and retinal proteins in taurine-depleted animals: isolation and identification of the phosphoproteins. Lombardini, J.B. Adv. Exp. Med. Biol. (1998) [Pubmed]
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