Gene Review:
Insr - insulin receptor
Rattus norvegicus
Synonyms:
IR, Insulin receptor
- Insulin receptor signaling in long-term memory consolidation following spatial learning. Dou, J.T., Chen, M., Dufour, F., Alkon, D.L., Zhao, W.Q. Learn. Mem. (2005)
- Exercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscle. Nadeau, K.J., Ehlers, L.B., Aguirre, L.E., Moore, R.L., Jew, K.N., Ortmeyer, H.K., Hansen, B.C., Reusch, J.E., Draznin, B. Am. J. Physiol. Endocrinol. Metab. (2006)
- The juxtamembrane but not the carboxyl-terminal domain of the insulin receptor mediates insulin's metabolic functions in primary adipocytes and cultured hepatoma cells. Paz, K., Boura-Halfon, S., Wyatt, L.S., LeRoith, D., Zick, Y. J. Mol. Endocrinol. (2000)
- Hyperinsulinemia instead of insulin resistance induces baroreflex dysfunction in chronic insulin-infused rats. Hong, L.Z., Hsieh, P.S. Am. J. Hypertens. (2007)
- Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway. Salkovic-Petrisic, M., Tribl, F., Schmidt, M., Hoyer, S., Riederer, P. J. Neurochem. (2006)
- Insulin resistance and promotion of aberrant crypt foci in the colons of rats on a high-fat diet. Koohestani, N., Tran, T.T., Lee, W., Wolever, T.M., Bruce, W.R. Nutrition and cancer. (1997)
- Insulin receptor phosphorylation may not be a prerequisite for acute insulin action. Simpson, I.A., Hedo, J.A. Science (1984)
- Insulin receptor antiserum and plant lectins mimic the direct effects of insulin on nuclear envelope phosphorylation. Purrello, F., Burnham, D.B., Goldfine, I.D. Science (1983)
- Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. Ren, D., Zhou, Y., Morris, D., Li, M., Li, Z., Rui, L. J. Clin. Invest. (2007)
- Central nervous system nitric oxide synthase activity regulates insulin secretion and insulin action. Shankar, R., Zhu, J.S., Ladd, B., Henry, D., Shen, H.Q., Baron, A.D. J. Clin. Invest. (1998)
- Insulin receptor tyrosine kinase activity and substrate 1 (IRS-1) expression in human myometrium and leiomyoma. Orcy, R.B., Brum, I., da Silva, R.S., Kucharski, L.C., Corleta, H.E., Capp, E. Eur. J. Obstet. Gynecol. Reprod. Biol. (2005)
- Vanadate, but not insulin, inhibits insulin receptor gene expression in rat hepatoma cells. Bortoli, S., Amessou, M., Collinet, M., Desbuquois, B., Lopez, S. Endocrinology (1997)
- Fructose-fed rats are protected against ischemia/reperfusion injury. Jordan, J.E., Simandle, S.A., Tulbert, C.D., Busija, D.W., Miller, A.W. J. Pharmacol. Exp. Ther. (2003)
- Differential regulation of insulin resistance and hypertension by sex hormones in fructose-fed male rats. Vasudevan, H., Xiang, H., McNeill, J.H. Am. J. Physiol. Heart Circ. Physiol. (2005)
- Sennidin stimulates glucose incorporation in rat adipocytes. Abe, D., Saito, T., Sekiya, K. Life Sci. (2006)
- Rats that are made insulin resistant by glucosamine treatment have impaired skeletal muscle insulin receptor phosphorylation. Spampinato, D., Giaccari, A., Trischitta, V., Costanzo, B.V., Morviducci, L., Buongiorno, A., Di Mario, U., Vigneri, R., Frittitta, L. Metab. Clin. Exp. (2003)
- Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B. Wu, Y., Ou-Yang, J.P., Wu, K., Wang, Y., Zhou, Y.F., Wen, C.Y. Acta Pharmacol. Sin. (2005)
- Cellular distribution of insulin-degrading enzyme gene expression. Comparison with insulin and insulin-like growth factor receptors. Bondy, C.A., Zhou, J., Chin, E., Reinhardt, R.R., Ding, L., Roth, R.A. J. Clin. Invest. (1994)
- Sustained activation of insulin receptors internalized in GLUT4 vesicles of insulin-stimulated skeletal muscle. Dombrowski, L., Faure, R., Marette, A. Diabetes (2000)
- Imaging on the binding of FITC-Insulin with Insulin Receptors in cortical neurons of Rat. Luo, Y., Xu, H., Huang, K., Zhang, Z., Luo, Q., Liu, Q. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference (2005)
- The vascular endothelial cell mediates insulin transport into skeletal muscle. Wang, H., Liu, Z., Li, G., Barrett, E.J. Am. J. Physiol. Endocrinol. Metab. (2006)
- Glucose concentration and AMP-dependent kinase activation regulate expression of insulin receptor family members in rat islets and INS-1E beta cells. Raile, K., Klammt, J., Laue, S., Garten, A., Blüher, M., Kralisch, S., Klöting, N., Kiess, W. Diabetologia (2005)
- Hexachlorobenzene is a tumor co-carcinogen and induces alterations in insulin-growth factors signaling pathway in the rat mammary gland. Randi, A.S., Cocca, C., Carbone, V., Nuñez, M., Croci, M., Gutiérrez, A., Bergoc, R., Kleiman de Pisarev, D.L. Toxicol. Sci. (2006)
- Insulin receptor (IR) and glucose transporter 2 (GLUT2) proteins form a complex on the rat hepatocyte membrane. Eisenberg, M.L., Maker, A.V., Slezak, L.A., Nathan, J.D., Sritharan, K.C., Jena, B.P., Geibel, J.P., Andersen, D.K. Cell. Physiol. Biochem. (2005)
- Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats. Hirata, A.E., Alvarez-Rojas, F., Carvalheira, J.B., Carvalho, C.R., Dolnikoff, M.S., Abdalla Saad, M.J. Life Sci. (2003)
- Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk. Folli, F., Kahn, C.R., Hansen, H., Bouchie, J.L., Feener, E.P. J. Clin. Invest. (1997)
- Dynamics of protein-tyrosine phosphatases in rat adipocytes. Calera, M.R., Vallega, G., Pilch, P.F. J. Biol. Chem. (2000)
- Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. Hotamisligil, G.S., Budavari, A., Murray, D., Spiegelman, B.M. J. Clin. Invest. (1994)
- Src tyrosine kinase regulates insulin-induced activation of protein kinase C (PKC) delta in skeletal muscle. Rosenzweig, T., Aga-Mizrachi, S., Bak, A., Sampson, S.R. Cell. Signal. (2004)
- Skeletal muscle insulin-receptor kinase. Effects of substrate inhibition and diabetes. Block, N.E., Komori, K., Dutton, S.L., Robinson, K.A., Buse, M.G. Diabetes (1991)
- Nuclear matrix association of insulin receptor and IRS-1 by insulin in osteoblast-like UMR-106 cells. Seol, K.C., Kim, S.J. Biochem. Biophys. Res. Commun. (2003)
- Rosiglitazone ameliorates abnormal expression and activity of protein tyrosine phosphatase 1B in the skeletal muscle of fat-fed, streptozotocin-treated diabetic rats. Wu, Y., Ouyang, J.P., Wu, K., Wang, S.S., Wen, C.Y., Xia, Z.Y. Br. J. Pharmacol. (2005)
- Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway. Ueno, M., Carvalheira, J.B., Tambascia, R.C., Bezerra, R.M., Amaral, M.E., Carneiro, E.M., Folli, F., Franchini, K.G., Saad, M.J. Diabetologia (2005)
- Expression and localization of insulin receptor in rat dorsal root ganglion and spinal cord. Sugimoto, K., Murakawa, Y., Sima, A.A. J. Peripher. Nerv. Syst. (2002)
- 14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner. Craparo, A., Freund, R., Gustafson, T.A. J. Biol. Chem. (1997)
- Dietary protein deprivation decreases the serine phosphorylation of insulin receptor substrate-1 in rat skeletal muscle. Toyoshima, Y., Ohne, Y., Takahashi, S.I., Noguchi, T., Kato, H. J. Mol. Endocrinol. (2004)