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Gene Review

ZEB1  -  zinc finger E-box binding homeobox 1

Homo sapiens

Synonyms: AREB6, BZP, DELTAEF1, FECD6, NIL-2-A, ...
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Disease relevance of ZEB1


High impact information on ZEB1


Biological context of ZEB1


Anatomical context of ZEB1


Associations of ZEB1 with chemical compounds

  • We identified a significant correlation between sensitivity to gefitinib and expression of E-cadherin, and ZEB1, suggesting their predictive value for responsiveness to EGFR-tyrosine kinase inhibitors [12].
  • ZEB1 protein is up-regulated in the myometrium and endometrial stroma after progesterone or estrogen treatment of ovariectomized mice [13].
  • In summary, ZEB1 is normally regulated by both estrogen and progesterone receptors, but in uterine cancers, it is likely no longer under control of steroid hormone receptors and becomes aberrantly expressed in epithelial-derived tumor cells, supporting a role for ZEB1 in epithelial to mesenchymal transitions associated with aggressive tumors [13].
  • Conversely, doxorubicin was found to inhibit NIL2A complex formation 50% at less than 1 microM, but did not achieve this level of inhibition of EGR1/DNA complex formation even at 50 microM [14].
  • Our results show that BZP/TFMPP and MDMA share the ability to evoke monoamine release, but dangerous drug-drug synergism may occur when piperazines are coadministered at high doses [15].

Regulatory relationships of ZEB1

  • A working model is presented to account for the role of DNA-PK and AREB6-like proteins in regulating hXOR activity [16].

Other interactions of ZEB1

  • However, the association between SNAIL and CDH1 was not found in patients with high expression of ZEB1 [1].
  • Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression [11].
  • Recent data provide evidence for interacting roles of ZEB1, p300, and a polymorphic 73 bp deletion in intron 1 of the human TP73 gene in this process [17].
  • The mRNA expression levels of SNAIL and ZEB1, and of transcriptional regulators p300 and CtBP, were measured by RT-PCR in tumor and normal tissue from 101 colon carcinoma patients [2].
  • Furthermore, when there were elevated p300 expression levels, the correlation between expression of ZEB1 and VDR was stronger (r = 0.38; p = 0.070) [2].

Analytical, diagnostic and therapeutic context of ZEB1


  1. E-cadherin and vitamin D receptor regulation by SNAIL and ZEB1 in colon cancer: clinicopathological correlations. Peña, C., García, J.M., Silva, J., García, V., Rodríguez, R., Alonso, I., Millán, I., Salas, C., de Herreros, A.G., Muñoz, A., Bonilla, F. Hum. Mol. Genet. (2005) [Pubmed]
  2. The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas. Peña, C., García, J.M., García, V., Silva, J., Domínguez, G., Rodríguez, R., Maximiano, C., García de Herreros, A., Muñoz, A., Bonilla, F. Int. J. Cancer (2006) [Pubmed]
  3. Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells. Krafchak, C.M., Pawar, H., Moroi, S.E., Sugar, A., Lichter, P.R., Mackey, D.A., Mian, S., Nairus, T., Elner, V., Schteingart, M.T., Downs, C.A., Kijek, T.G., Johnson, J.M., Trager, E.H., Rozsa, F.W., Mandal, M.N., Epstein, M.P., Vollrath, D., Ayyagari, R., Boehnke, M., Richards, J.E. Am. J. Hum. Genet. (2005) [Pubmed]
  4. Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer. Dohadwala, M., Yang, S.C., Luo, J., Sharma, S., Batra, R.K., Huang, M., Lin, Y., Goodglick, L., Krysan, K., Fishbein, M.C., Hong, L., Lai, C., Cameron, R.B., Gemmill, R.M., Drabkin, H.A., Dubinett, S.M. Cancer Res. (2006) [Pubmed]
  5. The presence of an intronic deletion in p73 and high levels of ZEB1 alter the TAp73/DeltaTAp73 ratio in colorectal carcinomas. Dom??nguez, G., Pe??a, C., Silva, J., Garc??a, J., Garc??a, V., Rodr??guez, R., Cantos, B., Citores, M., Espa??a, P., Bonilla, F. J. Pathol. (2006) [Pubmed]
  6. A Transient, EMT-Linked Loss of Basement Membranes Indicates Metastasis and Poor Survival in Colorectal Cancer. Spaderna, S., Schmalhofer, O., Hlubek, F., Berx, G., Eger, A., Merkel, S., Jung, A., Kirchner, T., Brabletz, T. Gastroenterology (2006) [Pubmed]
  7. Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors. Postigo, A.A., Dean, D.C. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  8. The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2. Williams, T.M., Montoya, G., Wu, Y., Eddy, R.L., Byers, M.G., Shows, T.B. Genomics (1992) [Pubmed]
  9. Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6. Ikeda, K., Halle, J.P., Stelzer, G., Meisterernst, M., Kawakami, K. Mol. Cell. Biol. (1998) [Pubmed]
  10. NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2. Chua, H.L., Bhat-Nakshatri, P., Clare, S.E., Morimiya, A., Badve, S., Nakshatri, H. Oncogene (2007) [Pubmed]
  11. Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. Guaita, S., Puig, I., Franci, C., Garrido, M., Dominguez, D., Batlle, E., Sancho, E., Dedhar, S., De Herreros, A.G., Baulida, J. J. Biol. Chem. (2002) [Pubmed]
  12. Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines. Witta, S.E., Gemmill, R.M., Hirsch, F.R., Coldren, C.D., Hedman, K., Ravdel, L., Helfrich, B., Dziadziuszko, R., Chan, D.C., Sugita, M., Chan, Z., Baron, A., Franklin, W., Drabkin, H.A., Girard, L., Gazdar, A.F., Minna, J.D., Bunn, P.A. Cancer Res. (2006) [Pubmed]
  13. The transcription factor ZEB1 is aberrantly expressed in aggressive uterine cancers. Spoelstra, N.S., Manning, N.G., Higashi, Y., Darling, D., Singh, M., Shroyer, K.R., Broaddus, R.R., Horwitz, K.B., Richer, J.K. Cancer Res. (2006) [Pubmed]
  14. Targeting DNA-binding drugs to sequence-specific transcription factor.DNA complexes. Differential effects of intercalating and minor groove binding drugs. Welch, J.J., Rauscher, F.J., Beerman, T.A. J. Biol. Chem. (1994) [Pubmed]
  15. N-substituted piperazines abused by humans mimic the molecular mechanism of 3,4-methylenedioxymethamphetamine (MDMA, or 'Ecstasy'). Baumann, M.H., Clark, R.D., Budzynski, A.G., Partilla, J.S., Blough, B.E., Rothman, R.B. Neuropsychopharmacology (2005) [Pubmed]
  16. Characterization of proteins binding to E-box/Ku86 sites and function of Ku86 in transcriptional regulation of the human xanthine oxidoreductase gene. Xu, P., LaVallee, P.A., Lin, J.J., Hoidal, J.R. J. Biol. Chem. (2004) [Pubmed]
  17. Regulating p73 isoforms in human tumours. Coates, P. J. Pathol. (2006) [Pubmed]
  18. Cell-specific phosphorylation of Zfhep transcription factor. Costantino, M.E., Stearman, R.P., Smith, G.E., Darling, D.S. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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