Disease relevance of TRC

• The feasibility of post-administration of STS without obvious nephrotoxicity in modified TRC was explained by transient inhibition of DDP delivery to the kidney during the AT-II-induced hypertension [1].
• Eighty-two stool specimens obtained from children with gastrointestinal disease were tested for the presence of antigen to rotavirus by latex agglutination (LA) (Virogen (VR), Meritec (MER), Wellcome (WEL), Slidex Rotatest (SRT), and enzyme-linked immunosorbent assays (Rotaclone [TRC], Rotazyme II [RTZ], Pathfinder [PTH]) [2].
• Among the diabetic groups, PTRC became higher and ARC/TRC became lower in conjunction with the degree of albuminuria [3].
• Patients with non-diabetic glomerulonephritis showed, to a lesser degree, low ratio of delta ARC/delta TRC (60.4 +/- 37.9%) in conjunction with higher level of PTRC (249 +/- 89 ng/l).(ABSTRACT TRUNCATED AT 250 WORDS)[3]
• Dermatoglyphic findings in 19 patients with phenylketonuria (11 male and 8 female), 39 of their relatives (18 female and 21 male) and 500 controls (TRC) were not statistically significant among the three groups studied [4].

Psychiatry related information on TRC

• Instead, the TRC process highlighted great mental health needs, which were not adequately met [5].

High impact information on TRC

• These results demonstrate the utility of high affinity TRC-like scFv recombinant Abs directed toward human cancer T cell epitopes [6].
• Analysis of Ag specificity of TRC-gamma delta+ T cells in humans has been hampered by the fact that cloned lines of these cells expanded in IL-2 generally display high NK-like cytotoxic activity [7].
• To investigate the effect of aging on the renin-angiotensin-aldosterone system, plasma renin substrate concentrations (PRSC); plasma total, active, and inactive renin concentrations (TRC, ARC, and IRC); PRA; and plasma aldosterone concentrations (PAC) were measured simultaneously in 60 normal subjects, 18-84 yr old [8].
• The sensitivities and negative predictive values of VR, MER, WEL, SRT, TRC, RTZ, and PTH tests were 85, 89, 95, 91, 98, and 100%, respectively [2].
• Obesity was defined as (1) a BMI greater than the NHANES III 85% centile or (2) the sum of TRCP and SSCP skinfolds greater than the NHANES III 85% centile [9].

Biological context of TRC

• The present study was designed to characterize TgAbs from patients with unusually high titers (greater than 1:5(12] using tanned red cell hemagglutination technique (TRC) [10].
• The circadian rhythm was validated at a high significance for TRC, ARC, PRA and at a borderline significance for PAC [11].
• Like the Zulus of Southern Africa, Southern Nigerian Negroes showed a significant sex difference in the atd angle but the Southern Nigerians have a significantly higher TRC than those previously reported for the Zulu [12].
• LDC and TRC in a dose-dependent fashion rapidly inhibited oxygen consumption and superoxide anion (O-2.) release by unstimulated human AM or AM stimulated by bacteria or the membrane-active chemical PMA [13].
• The figures do not speak against the hypothesis that genes affecting the TRC are located on the X-chromosome [14].

Anatomical context of TRC

• Therapy with T3, by inhibiting TSH, may have caused regression of inapparent immunologic thyroid lesion, thus leading to the disappearance of circulating TRC antibodies; alternatively, T3 specifically may have accelerated catabolism of thyroid antibodies [15].
• Lastly, after removal of a suppressive factor from postsurgical macrophage-spent media by dialysis, the factors secreted by postsurgical macrophages are more potent in enhancing TRC proliferation than growth factors individually [16].
• In addition, cells harvested from the site of peritoneal trauma (TRC) did not respond to growth factors in a fashion entirely the same as fibroblasts [16].
• The so-called TRC model consisted of interconnected modules, with each module comprised of a simple representations of parts of the reticular thalamic nucleus, specific thalamic nuclei, nonspecific thalamic nuclei, and cortex, together with the known excitatory and inhibitory interconnections between them [17].
• That is, macrophages either suppress or enhance the proliferation of TRC depending on the culture time and the medium used as a comparison, i.e., culture medium with only serum or spent medium from cultures of resident peritoneal macrophages [16].

Associations of TRC with chemical compounds

• (iii) Heparin, in concentrations up to 500 U/mL, exerted no significant effect on TRC of the media of human vascular smooth muscle cell culture [18].
• Concentrations of 2 mM TRC or 16 mM LDC reduced O2 consumption and O-2. release by unstimulated AM by more than 70% and blocked the usual spurt in O2 uptake and O-2. release observed for stimulated AM [13].
• One course of this TRC consisted of hepatic artery infusion of cisplatin, 120 mg/m2, in combination with concurrent intravenous administration of sodium thiosulfate, its neutralizing agent, at a dose of 9.0 g/m2 by a rapid push, followed by 1.2 g/m2/h by continuous infusion for 6 h [19].
• The efficacy of "two-route chemotherapy (TRC)" using a combination of cisplatin (DDP) and its antidote, sodium thiosulfate (STS), was evaluated in rat bladder tumor [20].
• Total and active renin concentrations (TRC and ARC) were determined in pregnant women and in women on estrogen-containing oral contraceptives to study the variation of plasma renin forms in pregnancy [21].

Other interactions of TRC

• The ratios of increments of PARC to that of PTRC, delta ARC/delta TRC, were 48.3 +/- 22.3, 35.1 +/- 10.4 and 8.4 +/- 8.1% in groups A, B, C, respectively; all of which were significantly lower than 84.2 +/- 48.6% in the control subjects [3].
• The active renin ratio was calculated as follows: ARC/TRC X 100% [8].
• In the one exceptional case, TRC-TG antibody titer decreased from 1280 to 80 after 7 mo of therapy [15].
• The mean PPD-TRC reaction of HIV-seropositive subjects were 6.4 +/- 0.9 mm vs. 11.0 +/- 0.5 mm among those with CD4 lymphocyte counts 200-299 cells/mm3 compared with those > or = 300 cells/mm3 (p < 0.001) [22].

Analytical, diagnostic and therapeutic context of TRC

• Real-time binding measurements using surface plasmon resonance have revealed kinetic and equilibrium parameters for the interactions between purified MHC molecules and peptides, between TCR and MHC-peptide complexes, and between TRC and superantigens [23].
• Using time-resolved cryo-transmission electron Microscopy (TRC-TEM), we have directly visualized the evolution of inverted phase micro-structure in liposomal aggregates [24].
• The present longitudinal study investigated whether increases in serum total renin concentration (TRC, active+prorenin) can predict the development of microalbuminuria in IDDM patients over a 10 year period [25].
• We studied the mechanism of the lamellar-to-inverted hexagonal (L alpha/H[II]) phase transition, using time-resolved cryotransmission electron microscopy (TRC-TEM), 31P-NMR, and differential scanning calorimetry [26].
• Dermatoglyphics show low TRC, distal or absent axial triradius, absent triradius C, and radial loop on digit 4 [27].

References