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Gene Review

Dab2  -  disabled 2, mitogen-responsive phosphoprotein

Rattus norvegicus

Synonyms: Adaptor molecule disabled-2, C9, DOC-2, Differentially expressed in ovarian carcinoma 2, Disabled homolog 2, ...
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Disease relevance of Dab2

  • Activation of the terminal complement cascade involving C5 to C9 proteins has a beneficial role for oligodendrocytes (OLG) in experimental allergic encephalomyelitis, an animal model of multiple sclerosis, by protecting them from apoptotic cell death [1].
  • Therefore, we tested the hypothesis that in neonatal rats subjected to a unilateral HI cerebral insult, prior administration of E. coli lipopolysaccharide (LPS) augments (1) complement-mediated serum hemolytic activity, and (2) C3 mRNA and C9 mRNA levels in hepatic and cerebral tissue [2].
  • Defibrase DF-521 batroxobin down-regulate ICAM-1 and complement C3d and C9 expression in the perihematomal area, and attenuate brain edema formation in ICH rats [3].
  • Immuno-histochemistry also showed that C3d deposition reduced significantly, and the Western blot analysis also showed the content of C9 protein declined around the hematoma in DF-521 batroxobin treatment group at 72 hours after ICH [3].

High impact information on Dab2

  • Northern and Western blot analyses indicated that Doc2 is present in PC12 cells [4].
  • We previously isolated a new protein having two C2-like domains which interacted with Ca2+ and phospholipid and named Doc2 (Double C2) [4].
  • Doc2 enhances Ca2+-dependent exocytosis from PC12 cells [4].
  • In the PC12 cells transfected with a plasmid with the coding sequence of Doc2 in the antisense orientation, the high K+-induced release of co-expressed GH was inversely inhibited [4].
  • Because Doc2 was abundantly expressed in brain where it was highly concentrated on the synaptic vesicle fraction, we have examined here whether Doc2 is involved in Ca2+-dependent exocytosis from cultured PC12 cells [4].

Biological context of Dab2


Anatomical context of Dab2

  • Taken together, our results suggest that C9 is up-regulated during prostate degeneration process and may play an active role in the proliferation and differentiation of prostatic epithelium [5].
  • Immunohistochemical analysis of rat VP demonstrated that C9 is detected in the basal epithelia and surrounding stromal cells after prolonged castration [5].
  • Doc2 is not associated with known regulated exocytotic or endosomal compartments in adrenal chromaffin cells [8].
  • We conclude that Doc2 is not a general component of regulated secretory vesicles, but may instead be associated with mitochondria [8].
  • To examine whether Doc2 is associated with synaptic-like microvesicles (SLMVs) or dense-core granules in neuroendocrine cells, we examined the distribution of Doc2 in subcellular fractionation of chromaffin cells of the adrenal medulla and in PC12 cells [8].

Associations of Dab2 with chemical compounds

  • The Doc2 mutant expressing an N-terminal fragment or a C-terminal fragment containing two C2-like domains inhibited the high K+-induced release of co-expressed GH [4].
  • Hepatic and cerebral C3 mRNA and C9 mRNA were quantified by qRT-PCR at 3, 6, and 18 h after HI [2].
  • Cerebral C9 mRNA was not detected and was not affected by HI, with or without the prior LPS administration [2].

Analytical, diagnostic and therapeutic context of Dab2


  1. C5b-9 terminal complex protects oligodendrocytes from apoptotic cell death by inhibiting caspase-8 processing and up-regulating FLIP. Cudrici, C., Niculescu, F., Jensen, T., Zafranskaia, E., Fosbrink, M., Rus, V., Shin, M.L., Rus, H. J. Immunol. (2006) [Pubmed]
  2. Effects of endotoxin administration and cerebral hypoxia-ischemia on complement activity and local transcriptional regulation in neonatal rats. Devlin, L.A., Nguyen, M.D., Figueroa, E., Gordon, L.E., Feldhoff, P.W., Lassiter, H.A. Neurosci. Lett. (2005) [Pubmed]
  3. Effects of venom defibrase on brain edema after intracerebral hemorrhage in rats. Wu, G., Huang, F.P. Acta Neurochir. Suppl. (2005) [Pubmed]
  4. Doc2 enhances Ca2+-dependent exocytosis from PC12 cells. Orita, S., Sasaki, T., Komuro, R., Sakaguchi, G., Maeda, M., Igarashi, H., Takai, Y. J. Biol. Chem. (1996) [Pubmed]
  5. Regulation of rat DOC-2 gene during castration-induced rat ventral prostate degeneration and its growth inhibitory function in human prostatic carcinoma cells. Tseng, C.P., Ely, B.D., Li, Y., Pong, R.C., Hsieh, J.T. Endocrinology (1998) [Pubmed]
  6. Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin. Oleinikov, A.V., Zhao, J., Makker, S.P. Biochem. J. (2000) [Pubmed]
  7. Calcium concentration threshold and translocation kinetics of EGFP-DOC2B expressed in cultured Aplysia neurons. Malkinson, G., Spira, M.E. Cell Calcium (2006) [Pubmed]
  8. Doc2 is not associated with known regulated exocytotic or endosomal compartments in adrenal chromaffin cells. Charvin, N., Williams, G., Burgoyne, R.D. Biochem. J. (1999) [Pubmed]
  9. Mucin secretion and PKC isoforms in SPOC1 goblet cells: differential activation by purinergic agonist and PMA. Abdullah, L.H., Bundy, J.T., Ehre, C., Davis, C.W. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  10. Involvement of Disabled-2 protein in the central nervous system inflammation following experimental cryoinjury of rat brains. Moon, C., Lee, J., Ahn, M., Shin, T. Neurosci. Lett. (2005) [Pubmed]
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