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Gene Review

NOX5  -  NADPH oxidase, EF-hand calcium binding...

Homo sapiens

Synonyms: NADPH oxidase 5, NOX5A, NOX5B
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Disease relevance of NOX5


High impact information on NOX5

  • In SEG1 cells, acid treatment increased mRNA expression of NOX5-S, but not NOX1, and knockdown of NOX5 by NOX5 small interfering RNA abolished acid-induced H(2)O(2) production [2].
  • This allows the inactivation of SHP-1 by NOX5-generated ROS and contributes to the maintenance of the constitutive activation of HCs [1].
  • By using RT-PCR and Southern and Western blotting and by measuring superoxide anion production in membrane fractions in the absence of cytosolic components, we demonstrate for the first time that HCs (but not circulating normal B cells or some other lymphoid cell types) express NOX5 [1].
  • Furthermore, SHP-1 in HCs coimmunoprecipitates with tyrosine phosphorylated CD22 and localizes in the same cellular compartment as NOX5 [1].
  • NADPH oxidase 5 (NOX5) is a homologue of the gp91(phox) subunit of the phagocyte NADPH oxidase [4].

Biological context of NOX5


Anatomical context of NOX5


Associations of NOX5 with chemical compounds

  • In this study, we have analyzed the mechanism of Ca(2+) activation of NOX5 [4].
  • Knockdown of NOX5 significantly decreased [(3)H]thymidine incorporation, which was restored by 10(-13) M H(2)O(2) [2].
  • The calcium ionophore ionomycin dramatically stimulated ferricytochrome c reduction in cell media, further supporting the importance of NOX5 for ROS production [3].
  • The involvement of PKC in NOX5 activation was investigated using myristate acetate (PMA), and the PKC inhibitor GF-109203X [8].

Other interactions of NOX5

  • We found that stomach biopsies of elderly patients expressed NOX5 and NOX2 mRNA, but not NOX1 [6].
  • Further, the analyzed part of the C. intestinalis genome and EST database do not seem to present p40phox and Nox5 [9].

Analytical, diagnostic and therapeutic context of NOX5

  • Gastric biopsies of hospitalized geriatric patients were analyzed for histology (Sidney classification), and real-time PCR was used to quantify mRNA expression of the superoxide-generating NADPH oxidases NOX1, NOX2, and NOX5 [6].


  1. Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. Kamiguti, A.S., Serrander, L., Lin, K., Harris, R.J., Cawley, J.C., Allsup, D.J., Slupsky, J.R., Krause, K.H., Zuzel, M. J. Immunol. (2005) [Pubmed]
  2. cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells. Fu, X., Beer, D.G., Behar, J., Wands, J., Lambeth, D., Cao, W. J. Biol. Chem. (2006) [Pubmed]
  3. NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells. Brar, S.S., Corbin, Z., Kennedy, T.P., Hemendinger, R., Thornton, L., Bommarius, B., Arnold, R.S., Whorton, A.R., Sturrock, A.B., Huecksteadt, T.P., Quinn, M.T., Krenitsky, K., Ardie, K.G., Lambeth, J.D., Hoidal, J.R. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  4. Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5). Bánfi, B., Tirone, F., Durussel, I., Knisz, J., Moskwa, P., Molnár, G.Z., Krause, K.H., Cox, J.A. J. Biol. Chem. (2004) [Pubmed]
  5. A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes. Bánfi, B., Molnár, G., Maturana, A., Steger, K., Hegedûs, B., Demaurex, N., Krause, K.H. J. Biol. Chem. (2001) [Pubmed]
  6. Expression of mRNA for ROS-generating NADPH oxidases in the aging stomach. Salles, N., Szanto, I., Herrmann, F., Armenian, B., Stumm, M., Stauffer, E., Michel, J.P., Krause, K.H. Exp. Gerontol. (2005) [Pubmed]
  7. NOX5 variants are functionally active in endothelial cells. Belaiba, R.S., Djordjevic, T., Petry, A., Diemer, K., Bonello, S., Banfi, B., Hess, J., Pogrebniak, A., Bickel, C., Görlach, A. Free Radic. Biol. Med. (2007) [Pubmed]
  8. A comparison of the NADPH oxidase in human sperm and white blood cells. Armstrong, J.S., Bivalacqua, T.J., Chamulitrat, W., Sikka, S., Hellstrom, W.J. Int. J. Androl. (2002) [Pubmed]
  9. Characteristics of NADPH oxidase genes (Nox2, p22, p47, and p67) and Nox4 gene expressed in blood cells of juvenile Ciona intestinalis. Inoue, Y., Ogasawara, M., Moroi, T., Satake, M., Azumi, K., Moritomo, T., Nakanishi, T. Immunogenetics (2005) [Pubmed]
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