Gene Review:
NCF4 - neutrophil cytosolic factor 4, 40kDa
Homo sapiens
Synonyms:
NCF, NCF-4, Neutrophil NADPH oxidase factor 4, Neutrophil cytosol factor 4, P40PHOX, ...
Wojnowski,
Kulle,
Schirmer,
Schlüter,
Schmidt,
Rosenberger,
Vonhof,
Bickeböller,
Toliat,
Suk,
Tzvetkov,
Kruger,
Seifert,
Kloess,
Hahn,
Loeffler,
Nürnberg,
Pfreundschuh,
Trümper,
Brockmöller,
Hasenfuss,
Inoue,
Ogasawara,
Moroi,
Satake,
Azumi,
Moritomo,
Nakanishi,
Rinckel,
Faris,
Hitt,
Kleinberg,
El Benna,
Dang,
Andrieu,
Vergnaud,
Dewas,
Cachia,
Fay,
Morel,
Chollet-Martin,
Hakim,
Gougerot-Pocidalo,
Vignais,
Chamulitrat,
Stremmel,
Kawahara,
Rokutan,
Fujii,
Wingler,
Schmidt,
Schmidt,
- A novel cytosolic component, p40phox, of respiratory burst oxidase associates with p67phox and is absent in patients with chronic granulomatous disease who lack p67phox. Tsunawaki, S., Mizunari, H., Nagata, M., Tatsuzawa, O., Kuratsuji, T. Biochem. Biophys. Res. Commun. (1994)
- Exercise-induced release of histamine and neutrophil chemotactic factor in atopic asthmatics. Lee, T.H., Brown, M.J., Nagy, L., Causon, R., Walport, M.J., Kay, A.B. J. Allergy Clin. Immunol. (1982)
- NF-kappaB activation and sustained IL-8 gene expression in primary cultures of cystic fibrosis airway epithelial cells stimulated with Pseudomonas aeruginosa. Joseph, T., Look, D., Ferkol, T. Am. J. Physiol. Lung Cell Mol. Physiol. (2005)
- Neutrophil chemotactic factor release and neutrophil alveolitis in asbestos-exposed individuals. Hayes, A.A., Rose, A.H., Musk, A.W., Robinson, B.W. Chest (1988)
- Fibroblasts isolated from human pterygia exhibit altered lipid metabolism characteristics. Peiretti, E., Dessì, S., Mulas, M.F., Abete, C., Galantuomo, M.S., Fossarello, M. Exp. Eye Res. (2006)
- Involvement of p40phox in activation of phagocyte NADPH oxidase through association of its carboxyl-terminal, but not its amino-terminal, with p67phox. Tsunawaki, S., Kagara, S., Yoshikawa, K., Yoshida, L.S., Kuratsuji, T., Namiki, H. J. Exp. Med. (1996)
- Identification and partial characterization of an exercise-induced neutrophil chemotactic factor in bronchial asthma. Lee, T.H., Nagy, L., Nagakura, T., Walport, M.J., Kay, A.B. J. Clin. Invest. (1982)
- Neutrophil chemotactic factors in the respiratory tract of patients with chronic airway diseases or idiopathic pulmonary fibrosis. Ozaki, T., Hayashi, H., Tani, K., Ogushi, F., Yasuoka, S., Ogura, T. Am. Rev. Respir. Dis. (1992)
- The Ku70 autoantigen interacts with p40phox in B lymphocytes. Grandvaux, N., Grizot, S., Vignais, P.V., Dagher, M.C. J. Cell. Sci. (1999)
- Demonstration of the interaction of thioredoxin with p40phox, a phagocyte oxidase component, using a yeast two-hybrid system. Nishiyama, A., Ohno, T., Iwata, S., Matsui, M., Hirota, K., Masutani, H., Nakamura, H., Yodoi, J. Immunol. Lett. (1999)
- Rac1 disrupts p67phox/p40phox binding: a novel role for Rac in NADPH oxidase activation. Rinckel, L.A., Faris, S.L., Hitt, N.D., Kleinberg, M.E. Biochem. Biophys. Res. Commun. (1999)
- The superoxide-generating NADPH oxidase: structural aspects and activation mechanism. Vignais, P.V. Cell. Mol. Life Sci. (2002)
- The 40-kDa component of the phagocyte NADPH oxidase (p40phox) is phosphorylated during activation in differentiated HL60 cells. Fuchs, A., Bouin, A.P., Rabilloud, T., Vignais, P.V. Eur. J. Biochem. (1997)
- Mechanisms of NADPH oxidase activation: translocation of p40phox, Rac1 and Rac2 from the cytosol to the membranes in human neutrophils lacking p47phox or p67phox. Dusi, S., Donini, M., Rossi, F. Biochem. J. (1996)
- A constitutive NADPH oxidase-like system containing gp91phox homologs in human keratinocytes. Chamulitrat, W., Stremmel, W., Kawahara, T., Rokutan, K., Fujii, H., Wingler, K., Schmidt, H.H., Schmidt, R. J. Invest. Dermatol. (2004)
- NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. Wojnowski, L., Kulle, B., Schirmer, M., Schlüter, G., Schmidt, A., Rosenberger, A., Vonhof, S., Bickeböller, H., Toliat, M.R., Suk, E.K., Tzvetkov, M., Kruger, A., Seifert, S., Kloess, M., Hahn, H., Loeffler, M., Nürnberg, P., Pfreundschuh, M., Trümper, L., Brockmöller, J., Hasenfuss, G. Circulation (2005)
- Genomic structure, chromosomal localization, start of transcription, and tissue expression of the human p40-phox, a new component of the nicotinamide adenine dinucleotide phosphate-oxidase complex. Zhan, S., Vazquez, N., Zhan, S., Wientjes, F.B., Budarf, M.L., Schrock, E., Ried, T., Green, E.D., Chanock, S.J. Blood (1996)
- Cytosolic phox proteins interact with and regulate the assembly of coronin in neutrophils. Grogan, A., Reeves, E., Keep, N., Wientjes, F., Totty, N.F., Burlingame, A.L., Hsuan, J.J., Segal, A.W. J. Cell. Sci. (1997)
- SH3 domain-mediated interactions involving the phox components of the NADPH oxidase. Wilson, L., Butcher, C., Finan, P., Kellie, S. Inflamm. Res. (1997)
- Phosphorylation of p40-phox during activation of neutrophil NADPH oxidase. Someya, A., Nunoi, H., Hasebe, T., Nagaoka, I. J. Leukoc. Biol. (1999)
- The NADPH oxidase components p47(phox) and p40(phox) bind to moesin through their PX domain. Wientjes, F.B., Reeves, E.P., Soskic, V., Furthmayr, H., Segal, A.W. Biochem. Biophys. Res. Commun. (2001)
- Characteristics of NADPH oxidase genes (Nox2, p22, p47, and p67) and Nox4 gene expressed in blood cells of juvenile Ciona intestinalis. Inoue, Y., Ogasawara, M., Moroi, T., Satake, M., Azumi, K., Moritomo, T., Nakanishi, T. Immunogenetics (2005)
- Identification of a splice variant mRNA of p40phox, an NADPH oxidase component of phagocytes. Hasebe, T., Someya, A., Nagaoka, I. FEBS Lett. (1999)
- P40phox associates with the neutrophil Triton X-100-insoluble cytoskeletal fraction and PMA-activated membrane skeleton: a comparative study with P67phox and P47phox. El Benna, J., Dang, P.M., Andrieu, V., Vergnaud, S., Dewas, C., Cachia, O., Fay, M., Morel, F., Chollet-Martin, S., Hakim, J., Gougerot-Pocidalo, M.A. J. Leukoc. Biol. (1999)
- The PC motif: a novel and evolutionarily conserved sequence involved in interaction between p40phox and p67phox, SH3 domain-containing cytosolic factors of the phagocyte NADPH oxidase. Nakamura, R., Sumimoto, H., Mizuki, K., Hata, K., Ago, T., Kitajima, S., Takeshige, K., Sakaki, Y., Ito, T. Eur. J. Biochem. (1998)