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Gene Review

RNF128  -  ring finger protein 128, E3 ubiquitin...

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase RNF128, FLJ23516, GRAIL, Gene related to anergy in lymphocytes protein, RING finger protein 128
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Disease relevance of RNF128


Psychiatry related information on RNF128

  • Yet the Holy Grail for this field--the discovery linkage between a chromosomal locus that is linked to a diseased gene--has thus far eluded us, whereas it has been grasped in such disorders as cystic fibrosis, Huntington's disease, and neurofibromatosis [6].
  • The development of an excellent mental health system at the national level or even the state or provincial jurisdiction resembles the search for the Holy Grail [7].

High impact information on RNF128


Chemical compound and disease context of RNF128


Biological context of RNF128


Anatomical context of RNF128


Associations of RNF128 with chemical compounds

  • For some 15 years the attainment of efficient, nonfluorinated CO2-active surfactants has been a Holy Grail for researchers spanning pure and applied chemical sciences [24].
  • Thus, the Holy Grail of steroid pharmacology is the development of agents which have a markedly improved therapeutic ratio than current steroids, especially on systemic administration [25].
  • Cortisol, DHEA, the Holy Grail and the fountain of youth [26].

Other interactions of RNF128


Analytical, diagnostic and therapeutic context of RNF128


  1. Soluble HIV suppressive factors: more than one Holy Grail? Clerici, M., Balotta, C., Galli, M. Immunol. Today (1996) [Pubmed]
  2. The Cushing syndrome: quest for the Holy Grail. Orth, D.N. Ann. Intern. Med. (1994) [Pubmed]
  3. Visceral analgesics and functional dyspepsia: have we found the Holy Grail? Talley, N.J. Gut (1997) [Pubmed]
  4. Predicting mortality in chronic obstructive pulmonary disease: chasing the "Holy Grail". Celli, B.R. Am. J. Respir. Crit. Care Med. (2006) [Pubmed]
  5. The Holy Grail: pathological indices in lupus nephritis. Schwartz, M.M. Kidney Int. (2000) [Pubmed]
  6. The role of psychological probes in genetic studies of schizophrenia. Holzman, P.S. Schizophr. Res. (1994) [Pubmed]
  7. Comparative mental health policy: are there lessons to be learned? Lurie, S. International review of psychiatry (Abingdon, England) (2005) [Pubmed]
  8. Dopamine: from Cinderella to Holy Grail. Mills, A. Trends Pharmacol. Sci. (1992) [Pubmed]
  9. cAMP response element binding protein family transcription factors: the Holy Grail of neurological therapeutics? Ratan, R.R. Ann. Neurol. (2004) [Pubmed]
  10. Keratinocyte growth factor--just another mitogen or the "Holy Grail" that regulates liver regeneration? Diehl, A.M. Hepatology (1995) [Pubmed]
  11. NF-kappaB: Holy Grail for rheumatoid arthritis? Firestein, G.S. Arthritis Rheum. (2004) [Pubmed]
  12. T-cell responses to autoantigens in IDDM. The search for the Holy Grail. Roep, B.O. Diabetes (1996) [Pubmed]
  13. Post-ERCP pancreatitis: is allopurinol the Holy Grail? Harewood, G.C., Topazian, M. Gastrointest. Endosc. (2005) [Pubmed]
  14. Refractory Status Epilepticus: Is EEG Burst Suppression an Appropriate Treatment Target during Drug-Induced Coma? What Is the Holy Grail? Bergey, G.K. Epilepsy currents / American Epilepsy Society (2006) [Pubmed]
  15. The immune tolerance network: the "Holy Grail" comes to the clinic. Bluestone, J.A., Matthews, J.B., Krensky, A.M. J. Am. Soc. Nephrol. (2000) [Pubmed]
  16. In search of the Holy Grail: the study of diastolic ventricular function by the use of Doppler echocardiography. Shapiro, S.M., Bersohn, M.M., Laks, M.M. J. Am. Coll. Cardiol. (1991) [Pubmed]
  17. Cancer or inflammation? A Holy Grail for nuclear medicine. Larson, S.M. J. Nucl. Med. (1994) [Pubmed]
  18. Negative regulators of cyclin-dependent kinases and their roles in cancers. Lee, M.H., Yang, H.Y. Cell. Mol. Life Sci. (2001) [Pubmed]
  19. Nanoscale science: a big step towards the Holy Grail of single molecule biochemistry and molecular biology. Doty, R.C., Fernig, D.G., Lévy, R. Cell. Mol. Life Sci. (2004) [Pubmed]
  20. Artificial blood vessel: the Holy Grail of peripheral vascular surgery. Kakisis, J.D., Liapis, C.D., Breuer, C., Sumpio, B.E. J. Vasc. Surg. (2005) [Pubmed]
  21. Ideal hepatocyte: quest for the Holy Grail. Sen, S., Jalan, R. J. Gastroenterol. Hepatol. (2005) [Pubmed]
  22. The Holy Grail of wood evolution - from wood anatomy to tissue-specific gene expression: to what extent do molecular studies of biosynthesis of cell wall biopolymers help the understanding of the evolution of woody species? Paul Bolwell, G., Patten, A.M., Lewis, N.G. Phytochemistry (2001) [Pubmed]
  23. The search for the Holy Grail: a century of anterior cruciate ligament reconstruction. Naranja, R.J., Corsetti, J., Kuhlman, J.R., Torg, J.S. Am J. Orthop. (1997) [Pubmed]
  24. Surfactants for CO(2). Eastoe, J., Gold, S., Steytler, D.C. Langmuir : the ACS journal of surfaces and colloids (2006) [Pubmed]
  25. New Glucocorticosteroids with an improved therapeutic ratio? Belvisi, M.G., Brown, T.J., Wicks, S., Foster, M.L. Pulmonary pharmacology & therapeutics. (2001) [Pubmed]
  26. Cortisol, DHEA, the Holy Grail and the fountain of youth. Eskandari, F., Cizza, G. J. Endocrinol. Invest. (2002) [Pubmed]
  27. Sex, SARS, and the Holy Grail. Schull, M.J. Emergency medicine journal : EMJ. (2003) [Pubmed]
  28. Molecular immunologic strategies to identify antigens and b-cell responses unique to multiple sclerosis. Gilden, D.H., Burgoon, M.P., Kleinschmidt-DeMasters, B.K., Williamson, R.A., Ghausi, O., Burton, D.R., Owens, G.P. Arch. Neurol. (2001) [Pubmed]
  29. Tissue transglutaminase: the Holy Grail for the diagnosis of celiac disease, at last? Fasano, A. J. Pediatr. (1999) [Pubmed]
  30. In search of the Holy Grail: NF1 mutation analysis and genotype-phenotype correlation. Viskochil, D. Genet. Med. (1999) [Pubmed]
  31. Induction of Transplantation Tolerance via Regulatory T Cells. Battaglia, M., Roncarolo, M.G. Inflammation & allergy drug targets. (2006) [Pubmed]
  32. Organ acceptance and rejection. Pescovitz, M.D. Curr. Opin. Immunol. (1992) [Pubmed]
  33. Immunosuppression: today, tomorrow, and withdrawal. Hirose, R., Vincenti, F. Semin. Liver Dis. (2006) [Pubmed]
  34. Immunotherapy. Oral route to Holy Grail? Palù, G., Parolin, C. Gene Ther. (2003) [Pubmed]
  35. Pharmacological approaches to the prevention of restenosis following angioplasty. The search for the Holy Grail? (Part I). Herrman, J.P., Hermans, W.R., Vos, J., Serruys, P.W. Drugs (1993) [Pubmed]
  36. Targeted radiotherapy: is the "Holy Grail" in sight? Mothersill, C., Seymour, C.B. J. Nucl. Med. (2006) [Pubmed]
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