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Gene Review

NAA15  -  N(alpha)-acetyltransferase 15, NatA...

Homo sapiens

Synonyms: FLJ13340, GA19, Ga19, Gastric cancer antigen Ga19, N-alpha-acetyltransferase 15, NatA auxiliary subunit, ...
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Disease relevance of NARG1


Psychiatry related information on NARG1

  • OBJECTIVE: To use Nath et al.'s (1991) conceptual model of adolescent parenting to examine the relationship between resiliency factors measured shortly after delivery and maternal parenting behavior at 6 months [5].

High impact information on NARG1

  • Recombinant protein from a selected clone catalyzed the three-step conversions of GA12 to GA25 and of GA53 to GA17, as well as the formation of the C19-GAs, GA1, GA9, and GA20, from their respective aldehyde precursors, GA23, GA24, and GA19 [6].
  • Plants treated with BX-112 had reduced levels of GA1 and GA8 and accumulated GA53, GA44, GA19, and GA20 [7].
  • The results provide the first direct evidence that vertebrate homologues of NAT1 and ARD1 form an evolutionarily conserved N-terminal acetyltransferase and suggest that expression and down-regulation of this enzyme complex plays an important role in the generation and differentiation of neurons [8].
  • FGF2 treatment regulates Ku, but not Tbdn100, protein accumulation [9].
  • Northern and Western blot analyses demonstrate expression of Ku and Tbdn100 in MC3T3E1 osteoblasts [9].

Chemical compound and disease context of NARG1


Biological context of NARG1

  • Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein N-alpha-acetyltransferase complex [11].
  • Our results argue for an essential role of the NATH-hARD1 complex in cell survival and underscore the importance of protein N-alpha-acetylation in mammalian cells [11].
  • NATH has two mRNA species, 4.6 and 5.8 kb, both harboring the same open reading frame encoding a putative protein of 866 amino acids [2].
  • In the NAT1 gene we found two SNPs and a 3-bp insertion/ deletion polymorphism that corresponded to the NAT1*3, *10, and *18A/*18B alleles reported in other populations [12].
  • Haloarchaeal N-terminal acetyltransferase reveals narrow substrate specificity, which is limited to cleaved N termini starting with serine or alanine residues [13].

Anatomical context of NARG1

  • Here, we demonstrate that knockdown of NATH and/or hARD1 triggers apoptosis in human cell lines [11].
  • A novel acetyltransferase subunit, tubedown-1 (tbdn-1), has been isolated, the expression of which is regulated during blood vessel development [3].
  • The most abundant gibberellins identified in exudates were GA19 and GA44, as well as other members of the early 13-hydroxylation pathway [14].

Associations of NARG1 with chemical compounds

  • Knockdown of hARD1 also sensitized cells to daunorubicin-induced apoptosis, potentially pointing at the NATH-hARD1 acetyltransferase complex as a novel target for chemotherapy [11].
  • In NB4 cells undergoing retinoic acid mediated differentiation, the level of endogenous hARD1 and NATH protein decreases while the level of hARD2 protein is stable [15].
  • These data support the hypothesis that the conversion of GA19 to GA20 in pea pericarp is seed regulated and that the auxin 4-CI-IAA can substitute for the seeds in the stimulation of pericarp growth and the conversion of GA19 to GA20 [16].
  • Nath and Rydon [Nath, R. L., & Rydon, H. N. (1954) Biochem. J. 57, 1-10] examined the kinetics of the beta-glucosidase-catalyzed hydrolysis of a series of substituted phenyl glucosides [17].
  • N-(2,2,5,7,8-Pentamethylchroman-6-sulfonyl)-N'-3- (N-9-fluorenylmethoxycarbonyl-glycinyl)propylguanidine (1) was prepared and utilized as an arginine surrogate (Narg) building block compatible with solid-phase synthesis according to the Fmoc methodology [18].

Other interactions of NARG1

  • These observations suggest that the association of APP with hARD1 and hNAT1 and/or their N-acetyltransferase activity contributes to the regulation of A beta generation [19].

Analytical, diagnostic and therapeutic context of NARG1

  • Taken together, these results suggest that NATH positively affects the level of hARD1 protein both in vivo and in cell cultures [1].
  • Immunoprecipitation experiments show that hARD2 protein potentially interacts with NATH, suggesting that hARD2-NATH complexes may be responsible for protein N-alpha-acetylation in human cells [15].
  • Gel supershift studies confirm sequence-specific DNA binding of Ku in the OCFRE complex; chromatin immunoprecipitation assays confirm association of Ku and Tbdn100 with the endogenous OC promoter [9].
  • Overlapping RT-PCR fragments from several PTC biopsies confirmed the NATH mRNA sequence [2].
  • Northern blots, semiquantitative RT-PCR experiments, TaqMan real-time RT-PCR experiments, and in situ hybridization verified the overexpression of NATH mRNA localized to tumor cells in PTC biopsies [2].


  1. Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms. Arnesen, T., Gromyko, D., Horvli, O., Fluge, Ø., Lillehaug, J., Varhaug, J.E. Thyroid (2005) [Pubmed]
  2. NATH, a novel gene overexpressed in papillary thyroid carcinomas. Fluge, Ø., Bruland, O., Akslen, L.A., Varhaug, J.E., Lillehaug, J.R. Oncogene (2002) [Pubmed]
  3. Suppressed expression of tubedown-1 in retinal neovascularization of proliferative diabetic retinopathy. Gendron, R.L., Good, W.V., Adams, L.C., Paradis, H. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  4. A new dominant selectable marker for use in Cryptococcus neoformans. McDade, H.C., Cox, G.M. Med. Mycol. (2001) [Pubmed]
  5. Resilience among African American adolescent mothers: predictors of positive parenting in early infancy. Hess, C.R., Papas, M.A., Black, M.M. Journal of pediatric psychology. (2002) [Pubmed]
  6. Expression cloning of a gibberellin 20-oxidase, a multifunctional enzyme involved in gibberellin biosynthesis. Lange, T., Hedden, P., Graebe, J.E. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  7. Gibberellin A1 is required for stem elongation in spinach. Zeevaart, J.A., Gage, D.A., Talon, M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  8. An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development. Sugiura, N., Adams, S.M., Corriveau, R.A. J. Biol. Chem. (2003) [Pubmed]
  9. Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex. Willis, D.M., Loewy, A.P., Charlton-Kachigian, N., Shao, J.S., Ornitz, D.M., Towler, D.A. J. Biol. Chem. (2002) [Pubmed]
  10. Experimental studies on pharmacology, metabolism and toxicology with tiadenol-disulfoxide. Dissociation of lipid lowering effects and the induction of peroxisomal and microsomal drug-metabolizing enzymes. Maffei Facino, R., Carini, M., Tofanetti, O., Casciarri, I., Longoni, E. Arzneimittel-Forschung. (1987) [Pubmed]
  11. Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein N-alpha-acetyltransferase complex. Arnesen, T., Gromyko, D., Pendino, F., Ryningen, A., Varhaug, J.E., Lillehaug, J.R. Oncogene (2006) [Pubmed]
  12. Identification of single-nucleotide polymorphisms (SNPs) of human N-acetyltransferase genes NAT1, NAT2, AANAT, ARD1 and L1CAM in the Japanese population. Sekine, A., Saito, S., Iida, A., Mitsunobu, Y., Higuchi, S., Harigae, S., Nakamura, Y. J. Hum. Genet. (2001) [Pubmed]
  13. Archaeal N-terminal Protein Maturation Commonly Involves N-terminal Acetylation: A Large-scale Proteomics Survey. Falb, M., Aivaliotis, M., Garcia-Rizo, C., Bisle, B., Tebbe, A., Klein, C., Konstantinidis, K., Siedler, F., Pfeiffer, F., Oesterhelt, D. J. Mol. Biol. (2006) [Pubmed]
  14. Cytokinins and gibberellins in sap exudate of the oil palm. Huntley, R.P., Jones, L.H., Hanke, D.E. Phytochemistry (2002) [Pubmed]
  15. Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase. Arnesen, T., Betts, M.J., Pendino, F., Liberles, D.A., Anderson, D., Caro, J., Kong, X., Varhaug, J.E., Lillehaug, J.R. BMC Biochem. (2006) [Pubmed]
  16. Seed and 4-chloroindole-3-acetic acid regulation of gibberellin metabolism in pea pericarp. van Huizen, R., Ozga, J.A., Reinecke, D.M., Twitchin, B., Mander, L.N. Plant Physiol. (1995) [Pubmed]
  17. Beta-glucosidase: substrate, solvent, and viscosity variation as probes of the rate-limiting steps. Dale, M.P., Kopfler, W.P., Chait, I., Byers, L.D. Biochemistry (1986) [Pubmed]
  18. Synthesis of an N-3-guanidinopropylglycine (Narg) derivative as a versatile building block for solid-phase peptide and peptoid synthesis. Heizmann, G., Felder, E.R. Pept. Res. (1994) [Pubmed]
  19. Interaction of N-terminal acetyltransferase with the cytoplasmic domain of beta-amyloid precursor protein and its effect on A beta secretion. Asaumi, M., Iijima, K., Sumioka, A., Iijima-Ando, K., Kirino, Y., Nakaya, T., Suzuki, T. J. Biochem. (2005) [Pubmed]
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