Gene Review:
ACVR1B - activin A receptor, type IB
Homo sapiens
Synonyms:
ACTR-IB, ACTRIB, ACVRLK4, ALK-4, ALK4, ...
- ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma. Su, G.H., Bansal, R., Murphy, K.M., Montgomery, E., Yeo, C.J., Hruban, R.H., Kern, S.E. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism. Xu, J., McKeehan, K., Matsuzaki, K., McKeehan, W.L. J. Biol. Chem. (1995)
- Overexpression of wild-type activin receptor alk4-1 restores activin antiproliferative effects in human pituitary tumor cells. Danila, D.C., Zhang, X., Zhou, Y., Haidar, J.N., Klibanski, A. J. Clin. Endocrinol. Metab. (2002)
- Activin A and activin receptors in the human thyroid: a link to the female predominance of goiter? Schulte, K.M., Jonas, C., Krebs, R., Röher, H.D. Horm. Metab. Res. (2000)
- Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Lewis, K.A., Gray, P.C., Blount, A.L., MacConell, L.A., Wiater, E., Bilezikjian, L.M., Vale, W. Nature (2000)
- Cripto forms a complex with activin and type II activin receptors and can block activin signaling. Gray, P.C., Harrison, C.A., Vale, W. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%. Murphy, K.M., Brune, K.A., Griffin, C., Sollenberger, J.E., Petersen, G.M., Bansal, R., Hruban, R.H., Kern, S.E. Cancer Res. (2002)
- Tumor-specific expression and alternate splicing of messenger ribonucleic acid encoding activin/transforming growth factor-beta receptors in human pituitary adenomas. Alexander, J.M., Bikkal, H.A., Zervas, N.T., Laws, E.R., Klibanski, A. J. Clin. Endocrinol. Metab. (1996)
- Identification of a functional binding site for activin on the type I receptor ALK4. Harrison, C.A., Gray, P.C., Koerber, S.C., Fischer, W., Vale, W. J. Biol. Chem. (2003)
- Phosphorylation regulation of the interaction between Smad7 and activin type I receptor. Liu, X., Nagarajan, R.P., Vale, W., Chen, Y. FEBS Lett. (2002)
- Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells. Bianco, C., Adkins, H.B., Wechselberger, C., Seno, M., Normanno, N., De Luca, A., Sun, Y., Khan, N., Kenney, N., Ebert, A., Williams, K.P., Sanicola, M., Salomon, D.S. Mol. Cell. Biol. (2002)
- Synergistic interaction between Gdf1 and Nodal during anterior axis development. Andersson, O., Reissmann, E., Jörnvall, H., Ibáñez, C.F. Dev. Biol. (2006)
- Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors. Zhang, L., Zhou, H., Su, Y., Sun, Z., Zhang, H., Zhang, L., Zhang, Y., Ning, Y., Chen, Y.G., Meng, A. Science (2004)
- Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling. Zhou, Y., Sun, H., Danila, D.C., Johnson, S.R., Sigai, D.P., Zhang, X., Klibanski, A. Mol. Endocrinol. (2000)
- Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP). Chapman, S.C., Woodruff, T.K. Mol. Endocrinol. (2001)
- SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7. DaCosta Byfield, S., Major, C., Laping, N.J., Roberts, A.B. Mol. Pharmacol. (2004)
- Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3. Besser, D. J. Biol. Chem. (2004)
- An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors. Harrison, C.A., Gray, P.C., Fischer, W.H., Donaldson, C., Choe, S., Vale, W. J. Biol. Chem. (2004)
- Activin receptors: cellular signalling by receptor serine kinases. Zimmerman, C.M., Mathews, L.S. Biochem. Soc. Symp. (1996)