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Gene Review

CD72  -  CD72 molecule

Homo sapiens

Synonyms: B-cell differentiation antigen CD72, CD72b, LYB2, Lyb-2
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Disease relevance of CD72


High impact information on CD72


Biological context of CD72


Anatomical context of CD72

  • We have investigated the role of human CD72 in mature B cell differentiation [1].
  • Taken together, these data demonstrate that CD72 is a key molecule in regulating mature B cell differentiation, particularly in preventing the differentiation of naive B cells into plasma cells, thus blocking the production of low-affinity antibodies [1].
  • Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses [11].
  • Since all T cells express CD5 constitutively, these data also suggest the existence of another ligand for CD72 [14].
  • In tissue, immunohistochemical staining revealed positivity for all known B-cell compartments; however, pulpa macrophages of the spleen and von Kupffer cells exhibited distinct positivity for CD72 also [4].

Associations of CD72 with chemical compounds


Physical interactions of CD72


Regulatory relationships of CD72


Other interactions of CD72

  • Upon BCR ligation, SHP-1 has been shown to associate with the BCR, the cytoplasmic protein-tyrosine kinases Lyn and Syk, and the inhibitory co-receptors CD22 and CD72 [10].
  • Engagement of CD72 had no effect on the IL-4-promoted hyperexpression of surface IgM [21].
  • The findings are discussed with reference to observations made on the triggering of murine B lymphocytes through Lyb-2 and within the context of previously defined human B cell activation pathways [20].
  • Interestingly, expression of CD27, whose signal induces the differentiation of B cells into plasma cells, was down-modulated by CD72 stimulation [1].
  • The CD5 protein was effective at concentrations as low as 0.15 microM and its effect could be abolished by preincubation with soluble recombinant CD72 but not by preincubation with control proteins, indicating the specificity of the binding [18].

Analytical, diagnostic and therapeutic context of CD72

  • Flow cytometry analysis and proliferation assays were used to determine 1) the ability of B-1a and B-2 cells to coexpress functionally relevant counterligands other than CD5 and CD72, and 2) the signaling capacity of CD5 and CD72 in terms of B cell activation and proliferation [2].
  • Using a pig radiation hybrid panel we found the porcine CD72 gene to be located on chromosome 1q21-28 in a region syntenic to human chromosome 9 [22].
  • Sequence analysis of CD72 mRNA showed significantly increased nucleotide mutations, including both nucleotide substitutions and deletions [23].
  • Although the specificity for CD72 was clear from immunoblotting, transfection and other experiments, staining with this reagent was inhibited when cells were pretreated with an Fc receptor-blocking antibody (CD16/CD32 specific) [24].


  1. CD72-mediated suppression of human naive B cell differentiation by down-regulating X-box binding protein 1. Yamazaki, T., Nagumo, H., Hayashi, T., Sugane, K., Agematsu, K. Eur. J. Immunol. (2005) [Pubmed]
  2. The CD5/CD72 receptor system is coexpressed with several functionally relevant counterstructures on human B cells and delivers a critical signaling activity. Cerutti, A., Trentin, L., Zambello, R., Sancetta, R., Milani, A., Tassinari, C., Adami, F., Agostini, C., Semenzato, G. J. Immunol. (1996) [Pubmed]
  3. Increased expression of the B-cell-regulatory molecule CD72 in primary Sjögren's syndrome. Smith, A.J., Gordon, T.P., Macardle, P.J. Tissue Antigens (2004) [Pubmed]
  4. Human Lyb-2 homolog CD72 is a marker for progenitor B-cell leukemias. Schwarting, R., Castello, R., Moldenhauer, G., Pezzutto, A., von Hoegen, I., Ludwig, W.D., Parnes, J.R., Dörken, B. Am. J. Hematol. (1992) [Pubmed]
  5. Identification of a human protein homologous to the mouse Lyb-2 B cell differentiation antigen and sequence of the corresponding cDNA. Von Hoegen, I., Nakayama, E., Parnes, J.R. J. Immunol. (1990) [Pubmed]
  6. The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. Van de Velde, H., von Hoegen, I., Luo, W., Parnes, J.R., Thielemans, K. Nature (1991) [Pubmed]
  7. Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling. Kumanogoh, A., Watanabe, C., Lee, I., Wang, X., Shi, W., Araki, H., Hirata, H., Iwahori, K., Uchida, J., Yasui, T., Matsumoto, M., Yoshida, K., Yakura, H., Pan, C., Parnes, J.R., Kikutani, H. Immunity (2000) [Pubmed]
  8. B-cell signalling via the C-type lectins CD23 and CD72. Gordon, J. Immunol. Today (1994) [Pubmed]
  9. Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury. Zhu, L., Bergmeier, W., Wu, J., Jiang, H., Stalker, T.J., Cieslak, M., Fan, R., Boumsell, L., Kumanogoh, A., Kikutani, H., Tamagnone, L., Wagner, D.D., Milla, M.E., Brass, L.F. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  10. SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates. Adachi, T., Wienands, J., Wakabayashi, C., Yakura, H., Reth, M., Tsubata, T. J. Biol. Chem. (2001) [Pubmed]
  11. Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses. Ishida, I., Kumanogoh, A., Suzuki, K., Akahani, S., Noda, K., Kikutani, H. Int. Immunol. (2003) [Pubmed]
  12. CD5-induced apoptosis of B cells in some patients with chronic lymphocytic leukemia. Pers, J.O., Berthou, C., Porakishvili, N., Burdjanadze, M., Le Calvez, G., Abgrall, J.F., Lydyard, P.M., Youinou, P., Jamin, C. Leukemia (2002) [Pubmed]
  13. Identity of human Lyb-2 and CD72 and localization of the gene to chromosome 9. Von Hoegen, I., Hsieh, C.L., Scharting, R., Francke, U., Parnes, J.R. Eur. J. Immunol. (1991) [Pubmed]
  14. CD72 ligation regulates defective naive newborn B cell responses. Howard, L.M., Reen, D.J. Cell. Immunol. (1997) [Pubmed]
  15. PU.1/Spi-1 is essential for the B cell-specific activity of the mouse CD72 promoter. Ying, H., Chang, J.F., Parnes, J.R. J. Immunol. (1998) [Pubmed]
  16. CD72 Down-Modulates BCR-Induced Signal Transduction and Diminishes Survival in Primary Mature B Lymphocytes. Li, D.H., Tung, J.W., Tarner, I.H., Snow, A.L., Yukinari, T., Ngernmaneepothong, R., Martinez, O.M., Parnes, J.R. J. Immunol. (2006) [Pubmed]
  17. Stimulation of tyrosine phosphorylation without inositol lipid hydrolysis in human B lymphocytes on engaging CD72. Kamal, M., Knox, K., Finney, M., Michell, R.H., Holder, M.J., Gordon, J. FEBS Lett. (1993) [Pubmed]
  18. Native soluble CD5 delivers a costimulatory signal to resting human B lymphocytes. Van de Velde, H., Thielemans, K. Cell. Immunol. (1996) [Pubmed]
  19. The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1. Wu, Y., Nadler, M.J., Brennan, L.A., Gish, G.D., Timms, J.F., Fusaki, N., Jongstra-Bilen, J., Tada, N., Pawson, T., Wither, J., Neel, B.G., Hozumi, N. Curr. Biol. (1998) [Pubmed]
  20. Stimulation of B lymphocytes via CD72 (human Lyb-2). Kamal, M., Katira, A., Gordon, J. Eur. J. Immunol. (1991) [Pubmed]
  21. Occupancy of CD72 (the CD5 counterstructure) enhances interleukin-4-dependent CD23 expression in resting B lymphocytes. Katira, A., Kamal, M., Gordon, J. Immunology (1992) [Pubmed]
  22. Various domains of the B-cell regulatory molecule CD72 has diverged at different rates in mammals: Cloning, transcription and mapping of porcine CD72. Bie Petersen, C., Nygård, A.B., Fredholm, M., Aasted, B., Salomonsen, J. Dev. Comp. Immunol. (2007) [Pubmed]
  23. Increased mutations of CD72 transcript in B-lymphocytes from adolescent patients with systemic lupus erythematosus. Kaneko, U., Toyabe, S., Hara, M., Uchiyama, M. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2006) [Pubmed]
  24. A unique CD72 epitope suggests a potential interaction with FcgammaRII/CD32 on B lineage lymphocytes. Yamashita, Y., Phee, H., Tudor, K.S., Rossi, M.I., Parnes, J.R., Coggeshall, K.M., Kincade, P.W. Hybridoma (2005) (2006) [Pubmed]
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