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Gene Review

DMTF1  -  cyclin D binding myb-like transcription...

Homo sapiens

Synonyms: Cyclin-D-binding Myb-like transcription factor 1, Cyclin-D-interacting Myb-like protein 1, DMP1, DMTF, MRUL, ...
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Disease relevance of DMTF1

  • Further study will be needed to determine whether gene-specific mutations implicate hDMP1 as a tumor suppressor in acute leukemias with deletions of the long arm of chromosome 7 or in other types of human malignancy [1].
  • Both Dmp1-null mice and individuals with a newly identified disorder, autosomal recessive hypophosphatemic rickets, manifest rickets and osteomalacia with isolated renal phosphate-wasting associated with elevated fibroblast growth factor 23 (FGF23) levels and normocalciuria [2].
  • Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism [2].
  • DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis [3].

High impact information on DMTF1


Biological context of DMTF1

  • Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns [5].
  • The hDMP1 cDNA contains a 2280bp open reading frame that shares a high degree of identity with the mDmp1 coding region [1].
  • DMP1 binds to one of the Ets binding sites (designated Ets C) and synergizes with c-Myb in activating CD13/APN expression [6].
  • Activation of CD13/APN required both the intact DNA binding and transactivation domains of DMP1 and was inhibited by D-type cyclins, but not by cyclins A, B, C, or H, in a CDK-independent manner [6].
  • DMP1 mRNA and protein are ubiquitously expressed throughout the cell cycle in mouse tissues and in representative cell lines [7].

Anatomical context of DMTF1

  • The 4.4kb hDMP1 messenger RNA is ubiquitously expressed in normal human tissues, with highest levels in testis and substructures within the brain [1].
  • These data indicate that two different Myb family proteins collaborate in regulating APN gene expression and point to a role for DMP1 in normal myeloid cell development [6].
  • In this report, we demonstrate that dentin matrix protein 1 (DMP1), which is localized in the nucleus during early differentiation of odontoblasts, is able to bind specifically with the DSPP promoter and activate its transcription [8].
  • Real-time PCR analyses of ADM and DMP-1 in a panel of healthy and carious pulpal tissue and also in immune system cells highlighted the heterogeneity of caries and indicated increased expression of ADM in neutrophils activated by bacterial products [9].
  • Elevated expression of BSP and OPN, along with a marked decrease of dentin sialoprotein and DMP-1 in RD, suggests a difference in the mechanism of formation of the two forms of dentin [10].

Associations of DMTF1 with chemical compounds

  • Both full-length recombinant DMP1 and post-translationally modified native DMP1 were able to nucleate hydroxyapatite (HAP) in the presence of type I collagen [11].
  • The group that received two applications of fluoride paste per year had a DMTF increment that was about 24% less than that of the control group; however, the DMFS increment was only 5% less [12].

Other interactions of DMTF1

  • We have cloned two novel, alternatively spliced messages of human cyclin D-binding Myb-like protein (hDMP1) [5].

Analytical, diagnostic and therapeutic context of DMTF1


  1. Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1). Bodner, S.M., Naeve, C.W., Rakestraw, K.M., Jones, B.G., Valentine, V.A., Valentine, M.B., Luthardt, F.W., Willman, C.L., Raimondi, S.C., Downing, J.R., Roussel, M.F., Sherr, C.J., Look, A.T. Gene (1999) [Pubmed]
  2. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Feng, J.Q., Ward, L.M., Liu, S., Lu, Y., Xie, Y., Yuan, B., Yu, X., Rauch, F., Davis, S.I., Zhang, S., Rios, H., Drezner, M.K., Quarles, L.D., Bonewald, L.F., White, K.E. Nat. Genet. (2006) [Pubmed]
  3. DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. Lorenz-Depiereux, B., Bastepe, M., Benet-Pag??s, A., Amyere, M., Wagenstaller, J., M??ller-Barth, U., Badenhoop, K., Kaiser, S.M., Rittmaster, R.S., Shlossberg, A.H., Olivares, J.L., Loris, C., Ramos, F.J., Glorieux, F., Vikkula, M., J??ppner, H., Strom, T.M. Nat. Genet. (2006) [Pubmed]
  4. Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1. Inoue, K., Roussel, M.F., Sherr, C.J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  5. Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns. Tschan, M.P., Fischer, K.M., Fung, V.S., Pirnia, F., Borner, M.M., Fey, M.F., Tobler, A., Torbett, B.E. J. Biol. Chem. (2003) [Pubmed]
  6. Regulation of the CD13/aminopeptidase N gene by DMP1, a transcription factor antagonized by D-type cyclins. Inoue, K., Sherr, C.J., Shapiro, L.H. J. Biol. Chem. (1998) [Pubmed]
  7. Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1. Hirai, H., Sherr, C.J. Mol. Cell. Biol. (1996) [Pubmed]
  8. Dentin matrix protein 1 regulates dentin sialophosphoprotein gene transcription during early odontoblast differentiation. Narayanan, K., Gajjeraman, S., Ramachandran, A., Hao, J., George, A. J. Biol. Chem. (2006) [Pubmed]
  9. Gene expression profiling of pulpal tissue reveals the molecular complexity of dental caries. McLachlan, J.L., Smith, A.J., Bujalska, I.J., Cooper, P.R. Biochim. Biophys. Acta (2005) [Pubmed]
  10. Immunohistochemical study of small integrin-binding ligand, N-linked glycoproteins in reactionary dentin of rat molars at different ages. Moses, K.D., Butler, W.T., Qin, C. Eur. J. Oral Sci. (2006) [Pubmed]
  11. Matrix macromolecules in hard tissues control the nucleation and hierarchical assembly of hydroxyapatite. Gajjeraman, S., Narayanan, K., Hao, J., Qin, C., George, A. J. Biol. Chem. (2007) [Pubmed]
  12. Effect on caries of self-application of a zirconium silicate paste containing 9% stannous fluoride. Fleming, W.J., Burgess, R.C., Lewis, D.W. Community dentistry and oral epidemiology. (1976) [Pubmed]
  13. Biological markers for evaluation of root resorption. Balducci, L., Ramachandran, A., Hao, J., Narayanan, K., Evans, C., George, A. Arch. Oral Biol. (2007) [Pubmed]
  14. ELSID-Diabetes study-evaluation of a large scale implementation of disease management programmes for patients with type 2 diabetes. Rationale, design and conduct--a study protocol [ISRCTN08471887]. Joos, S., Rosemann, T., Heiderhoff, M., Wensing, M., Ludt, S., Gensichen, J., Kaufmann-Kolle, P., Szecsenyi, J. BMC public health [electronic resource]. (2005) [Pubmed]
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