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MeSH Review

Urethral Obstruction

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Disease relevance of Urethral Obstruction


High impact information on Urethral Obstruction

  • PURPOSE: Rapid bladder growth associated, partial urethral obstruction and embryonic bladder development entail stromal-epithelial interactions involving signaling by the cytokine transforming growth factor-beta (TGF-beta) [6].
  • Effect of preemptive treatment of capsaicin or resiniferatoxin on the development of pre-micturition contractions after partial urethral obstruction in the rat [7].
  • PURPOSE: To determine the role of N-methyl-D-aspartate (NMDA) glutamatergic receptors in the development of functional bladder changes after partial urethral obstruction we investigated the effects of repeat injection of MK-801, a noncompetitive NMDA receptor antagonist, on the micturition reflex in conscious obstructed rats [8].
  • The CTGF mRNA levels seemed to peak within the second week of the urethral obstruction and correlate well with increased type I collagen mRNA [9].
  • The diminished contractile response to field stimulation and carbachol secondary to urethral obstruction was significantly reversed by Tadenan treatment [10].

Chemical compound and disease context of Urethral Obstruction


Anatomical context of Urethral Obstruction


Gene context of Urethral Obstruction


  1. Cytokine gene expression during experimental Escherichia coli pyelonephritis in mice. Khalil, A., Brauner, A., Bakhiet, M., Burman, L.G., Jaremko, G., Wretlind, B., Tullus, K. J. Urol. (1997) [Pubmed]
  2. Adult onset nocturnal enuresis. Sakamoto, K., Blaivas, J.G. J. Urol. (2001) [Pubmed]
  3. Inheritance of urinary calculi in the Dalmatian. Bannasch, D.L., Ling, G.V., Bea, J., Famula, T.R. J. Vet. Intern. Med. (2004) [Pubmed]
  4. Xanthinuria in a family of Cavalier King Charles spaniels. van Zuilen, C.D., Nickel, R.F., van Dijk, T.H., Reijngoud, D.J. The Veterinary quarterly. (1997) [Pubmed]
  5. Similarity of the American Urological Association Symptom Index among men with benign prostate hyperplasia (BPH), urethral obstruction not due to BPH and detrusor hyperreflexia without outlet obstruction. Chancellor, M.B., Rivas, D.A., Keeley, F.X., Lotfi, M.A., Gomella, L.G. British journal of urology. (1994) [Pubmed]
  6. Stromal hyperplasia in male bladders upon loss of transforming growth factor-beta signaling in fibroblasts. Sharif-Afshar, A.R., Donohoe, J.M., Pope, J.C., Adams, M.C., Brock, J.W., Bhowmick, N.A. J. Urol. (2005) [Pubmed]
  7. Effect of preemptive treatment of capsaicin or resiniferatoxin on the development of pre-micturition contractions after partial urethral obstruction in the rat. Tanaka, H., Kakizaki, H., Shibata, T., Mitsui, T., Koyanagi, T. J. Urol. (2003) [Pubmed]
  8. Effects of chronic blockade of N-methyl-D-aspartate receptors by MK-801 on neuroplasticity of the micturition reflex pathway after partial urethral obstruction in the rat. Tanaka, H., Kakizaki, H., Shibata, T., Ameda, K., Koyanagi, T. J. Urol. (2003) [Pubmed]
  9. Cyr61 and CTGF are molecular markers of bladder wall remodeling after outlet obstruction. Chaqour, B., Whitbeck, C., Han, J.S., Macarak, E., Horan, P., Chichester, P., Levin, R. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  10. Improved contractility of obstructed bladders after Tadenan treatment is associated with reversal of altered myosin isoform expression. Gomes, C.M., Disanto, M.E., Horan, P., Levin, R.M., Wein, A.J., Chacko, S. J. Urol. (2000) [Pubmed]
  11. Lactic acid in urine of children with lower and upper urinary tract infection and renal obstruction. Brook, I., Belman, A.B., Controni, G. Am. J. Clin. Pathol. (1981) [Pubmed]
  12. Effects of short-term treatment with the alpha 1-blocker alfuzosin on urodynamic pressure/flow parameters in patients with benign prostatic hyperplasia. Martorana, G., Giberti, C., Di Silverio, F., von Heland, M., Rigatti, P., Colombo, R., Casadei, G., Pacifico, P. Eur. Urol. (1997) [Pubmed]
  13. Characterization of magnesium-induced urinary disease in the cat and comparison with feline urologic syndrome. Finco, D.R., Barsanti, J.A., Crowell, W.A. Am. J. Vet. Res. (1985) [Pubmed]
  14. Urinary acidification in the prevention and treatment of feline struvite urolithiasis. Taton, G.F., Hamar, D.W., Lewis, L.D. J. Am. Vet. Med. Assoc. (1984) [Pubmed]
  15. A novel canine model of partial outlet obstruction secondary to prostatic hypertrophy. Broderick, G.A., Longhurst, P.A., Juniewicz, P.E., Wein, A.J., Levin, R.M. World journal of urology. (1994) [Pubmed]
  16. Histological study of fetal kidney with urethral obstruction and vesicoureteral reflux: a consideration on the etiology of congenital reflux nephropathy. Shimada, K., Matsumoto, F., Tohda, A., Ueda, M. International journal of urology : official journal of the Japanese Urological Association. (2003) [Pubmed]
  17. Alpha-adrenergic agents in urinary disorders of the proximal urethra. Part II. Urethral obstruction due to "sympathetic dyssynergia". Awad, S.A., Downie, J.W., Kiruluta, H.G. British journal of urology. (1978) [Pubmed]
  18. Renal cytokine responses in acute Escherichia coli pyelonephritis in IL-6-deficient mice. Khalil, A., Tullus, K., Bartfai, T., Bakhiet, M., Jaremko, G., Brauner, A. Clin. Exp. Immunol. (2000) [Pubmed]
  19. Angiotensin II and bladder obstruction in the rat: influence on hypertrophic growth and contractility. Persson, K., Pandita, R.K., Waldeck, K., Andersson, K.E. Am. J. Physiol. (1996) [Pubmed]
  20. Animal models of renal fibrosis. Zeisberg, M., Soubasakos, M.A., Kalluri, R. Methods Mol. Med. (2005) [Pubmed]
  21. The origin of vesico-ureteric reflux in male newborns: further evidence in favour of a transient fetal urethral obstruction. Avni, E.F., Schulman, C.C. British journal of urology. (1996) [Pubmed]
  22. Simple sling incision for the treatment of iatrogenic urethral obstruction. Goldman, H.B. Urology (2003) [Pubmed]
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