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MeSH Review

Eating Disorders

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Disease relevance of Eating Disorders


Psychiatry related information on Eating Disorders


High impact information on Eating Disorders


Chemical compound and disease context of Eating Disorders


Biological context of Eating Disorders


Anatomical context of Eating Disorders

  • Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: relation to clinical and biochemical variable [25].
  • In patients with eating disorder, logarithmic values for leptin were significantly correlated with the body fat mass (r = .828, P < .001), eating behavior score (r = .777, P < .001), and LH (r = .465, P < .001), FSH (r = .440, P < .001), T3 (r = .572, P < .001), insulin (r = .410, P < .001), and cortisol (r = -.389, P < .001) levels [26].
  • The future of brain stimulation will depend on new technologies (new circuits, electrodes, web based programmers), waveforms (alternatives to square waves, random distribution), targets (hypothalamic nuclei, locus coeruleus) and indications (dystonia, epilepsy, eating disorders [27].
  • Thus, clinical studies have evaluated the possibility that CNS neuropeptide alterations may contribute to dysregulated secretion of the gonadal hormones, cortisol, thyroid hormones and growth hormone in the eating disorders [28].

Gene context of Eating Disorders

  • Recently novel non-peptidic antagonists directed against CRH-R1 or CRH-R2 have been proposed as promising agents in the treatment of depression, anxiety and eating disorder [29].
  • Preclinical data indicate that corticotropin-releasing hormone (CRH) has anxiogenic properties and a dysregulation in CRH systems has been suggested to play a role in a variety of stress-related psychiatric disorders, such as anxiety, depression, and eating disorders [30].
  • The present study therefore investigated the ability of CRH to inhibit the GH response to GHRH in eight young women with anorexia nervosa (AN) and in seven young women with eating disorders which were not otherwise specified (NOS) [31].
  • Recently, we found that serum levels of BDNF in patients with eating disorders are significantly decreased compared with normal controls [32].
  • We found no association between p.V66M or the additionally genotyped variant c.-46C > T and obesity, ADHD or eating disorders [33].

Analytical, diagnostic and therapeutic context of Eating Disorders


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  7. Adiponectin in anorexia nervosa and bulimia nervosa. Tagami, T., Satoh, N., Usui, T., Yamada, K., Shimatsu, A., Kuzuya, H. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  8. Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disorders. Hesse, S., Barthel, H., Schwarz, J., Sabri, O., Müller, U. Neuroscience and biobehavioral reviews. (2004) [Pubmed]
  9. Melatonin rhythms in women with anorexia nervosa and bulimia nervosa. Mortola, J.F., Laughlin, G.A., Yen, S.S. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  10. Prevalence of eating disorder symptoms in preadolescent and adolescent girls with IDDM. Striegel-Moore, R.H., Nicholson, T.J., Tamborlane, W.V. Diabetes Care (1992) [Pubmed]
  11. Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Tecott, L.H., Sun, L.M., Akana, S.F., Strack, A.M., Lowenstein, D.H., Dallman, M.F., Julius, D. Nature (1995) [Pubmed]
  12. Cocaine abuse and eating disorders. Jonas, J.M., Gold, M.S. Lancet (1986) [Pubmed]
  13. The CRF peptide family and their receptors: yet more partners discovered. Dautzenberg, F.M., Hauger, R.L. Trends Pharmacol. Sci. (2002) [Pubmed]
  14. Molecular manipulations as tools for enhancing our understanding of 5-HT neurotransmission. Murphy, D.L., Wichems, C., Li, Q., Heils, A. Trends Pharmacol. Sci. (1999) [Pubmed]
  15. Symptomatic relapse in bulimia nervosa following acute tryptophan depletion. Smith, K.A., Fairburn, C.G., Cowen, P.J. Arch. Gen. Psychiatry (1999) [Pubmed]
  16. Changes in melatonin levels but not cortisol levels are associated with depression in patients with eating disorders. Kennedy, S.H., Garfinkel, P.E., Parienti, V., Costa, D., Brown, G.M. Arch. Gen. Psychiatry (1989) [Pubmed]
  17. Autoantibodies against neuropeptides are associated with psychological traits in eating disorders. Fetissov, S.O., Harro, J., Jaanisk, M., Järv, A., Podar, I., Allik, J., Nilsson, I., Sakthivel, P., Lefvert, A.K., Hökfelt, T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  18. Evidence for the segregation of a major gene for human plasma GABA levels. Petty, F., Fulton, M., Kramer, G.L., Kram, M., Davis, L.L., Rush, A.J. Mol. Psychiatry (1999) [Pubmed]
  19. Association between the insulin-like growth factor 2 gene (IGF2) and scores on the Eating Attitudes Test in nonclinical subjects: a family-based study. Bachner-Melman, R., Zohar, A.H., Nemanov, L., Heresco-Levy, U., Gritsenko, I., Ebstein, R.P. The American journal of psychiatry. (2005) [Pubmed]
  20. Naltrexone improves blood glucose control in type 1 diabetic women with severe and chronic eating disorders. Raingeard, I., Courtet, P., Renard, E., Bringer, J. Diabetes Care (2004) [Pubmed]
  21. Serotonin and the neuroendocrine regulation of the hypothalamic--pituitary-adrenal axis in health and disease. Hanley, N.R., Van de Kar, L.D. Vitam. Horm. (2003) [Pubmed]
  22. Association between 5HT2A receptor gene promoter region polymorphism and eating disorders in Japanese patients. Nishiguchi, N., Matsushita, S., Suzuki, K., Murayama, M., Shirakawa, O., Higuchi, S. Biol. Psychiatry (2001) [Pubmed]
  23. Stress fracture injury in young military men and women. Armstrong, D.W., Rue, J.P., Wilckens, J.H., Frassica, F.J. Bone (2004) [Pubmed]
  24. Tyrosine improves appetite, cognition, and exercise tolerance in activity anorexia. Avraham, Y., Hao, S., Mendelson, S., Berry, E.M. Medicine and science in sports and exercise. (2001) [Pubmed]
  25. Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: relation to clinical and biochemical variable. Demitrack, M.A., Heyes, M.P., Altemus, M., Pigott, T.A., Gold, P.W. Biol. Psychiatry (1995) [Pubmed]
  26. Leptin in women with eating disorders. Nakai, Y., Hamagaki, S., Kato, S., Seino, Y., Takagi, R., Kurimoto, F. Metab. Clin. Exp. (1999) [Pubmed]
  27. Future prospects of brain stimulation. Benabid, A.L., Koudsié, A., Pollak, P., Kahane, P., Chabardes, S., Hirsch, E., Marescaux, C., Benazzouz, A. Neurol. Res. (2000) [Pubmed]
  28. A review of neuropeptide and neuroendocrine dysregulation in anorexia and bulimia nervosa. Bailer, U.F., Kaye, W.H. Current drug targets. CNS and neurological disorders. (2003) [Pubmed]
  29. Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls. Hiroi, N., Wong, M.L., Licinio, J., Park, C., Young, M., Gold, P.W., Chrousos, G.P., Bornstein, S.R. Mol. Psychiatry (2001) [Pubmed]
  30. Corticotropin-releasing hormone receptor subtypes and emotion. Steckler, T., Holsboer, F. Biol. Psychiatry (1999) [Pubmed]
  31. Corticotrophin-releasing hormone does not inhibit growth hormone-releasing hormone-induced release of growth hormone in control subjects but is effective in patients with eating disorders. Rolla, M., Andreoni, A., Bellitti, D., Ferdeghini, M., Ghigo, E., Müller, E.E. J. Endocrinol. (1994) [Pubmed]
  32. Role of brain-derived neurotrophic factor in eating disorders: recent findings and its pathophysiological implications. Hashimoto, K., Koizumi, H., Nakazato, M., Shimizu, E., Iyo, M. Prog. Neuropsychopharmacol. Biol. Psychiatry (2005) [Pubmed]
  33. Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder. Friedel, S., Horro, F.F., Wermter, A.K., Geller, F., Dempfle, A., Reichwald, K., Smidt, J., Brönner, G., Konrad, K., Herpertz-Dahlmann, B., Warnke, A., Hemminger, U., Linder, M., Kiefl, H., Goldschmidt, H.P., Siegfried, W., Remschmidt, H., Hinney, A., Hebebrand, J. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2005) [Pubmed]
  34. Measurement of CSF dynorphin A 1-8 immunoreactivity in anorexia nervosa and normal-weight bulimia. Lesem, M.D., Berrettini, W.H., Kaye, W.H., Jimerson, D.C. Biol. Psychiatry (1991) [Pubmed]
  35. Visualisation of serotonin-1A (5-HT1A) receptors in the central nervous system. Passchier, J., van Waarde, A. European journal of nuclear medicine. (2001) [Pubmed]
  36. Effect of inositol on bulimia nervosa and binge eating. Gelber, D., Levine, J., Belmaker, R.H. The International journal of eating disorders. (2001) [Pubmed]
  37. Brain glucose metabolism in eating disorders assessed by positron emission tomography. Delvenne, V., Goldman, S., De Maertelaer, V., Lotstra, F. The International journal of eating disorders. (1999) [Pubmed]
  38. Urinary steroids in young women with eating disorders. Poór, V., Bíró, I., Bufa, A., Gáti, A., Fenyvesi, I., Juricskay, S., Tényi, T., Kilár, F. J. Biochem. Biophys. Methods (2004) [Pubmed]
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