Disease relevance of Life Support Care

• Such treatment, called combined androgen blockade, has led to the first demonstration of a prolongation of life in prostate cancer [1].
• Mice treated with sodium hexachloroiridate after tumor injection either have significant prolongation of life span without ascites or show no evidence of cancer even up to 7 months after tumor injection [2].
• Previous studies have demonstrated that IL-15 administration after cyclophosphamide (CY) injection of C57BL/6J mice bearing the i.m. 76-9 rhabdomyosarcoma resulted in a significant prolongation of life [3].
• OBJECTIVE: It has been suggested that reduction in glucose levels contributes to the prolongation of life span of rodents in conjunction with restricted food intake, and hyperglycemia has been confirmed as a risk factor for cardiovascular disease (CVD), raising the possibility that better glycemic control could slow the progression of CVD [4].
• The repeated administration of a monoclonal anti-Sm antibody (KSml) resulted in a significant prolongation of life in MRL-lpr/lpr lupus mice with a 50% mortality of 36 weeks compared with 18-24 weeks in the control groups [5].

Psychiatry related information on Life Support Care

• Although a number of ethical issues have been identified with TPN use, the most pressing issues are equitable access to the technology; potential injustices toward other members of society because of the cost of the technology; quality of life issues, including prolongation of life; and decision making for TPN use [6].

High impact information on Life Support Care

• The effect on cultured cells suggested that KW2152 was not cross-resistant to Adriamycin (ADM) but was cross-resistant to mitomycin C (MMC); however, KW2152 caused prolongation of life span against mice bearing P388/ADM or P388/MMC [7].
• Prolongation of life with angiotensin converting enzyme inhibitor therapy [8].
• Combining topical and parenteral cidofovir treatments provided the greatest reduction in lesion severity and prolongation of life [9].
• We are left, however, with the impression that prolongation of life, relatively elevated levels of serum bilirubin, and protracted assisted ventilation (with either CPAP or PEEP) are intimately related to their formation [10].
• Further study of prolongation of life span associated with immunological modification by chronic low-dose-rate irradiation in MRL-lpr/lpr mice: effects of whole-life irradiation [11].

Chemical compound and disease context of Life Support Care

• Neplanocin A has cytotoxicity against L5178Y cells in culture and showed a remarkable effect on the life prolongation of mice infected with L1210 leukemia [12].
• The nitrone-based free radical traps have significant potential in the treatment of neurodegenerative diseases as well as in the prolongation of life span [13].
• The life-prolongation effect of MCNU against established Lewis lung carcinoma was similar to that of methyl-CCNU [14].
• Although fluconazole appeared less active than ketoconazole in vitro, in experiments involving 3 weeks of treatment and 2 months of observation, fluconazole was greater than 10 times as potent (mg/kg) in vivo against blastomycosis (prolongation of life) [15].

Associations of Life Support Care with chemical compounds

• This brief review considers the potential role of melatonin in the processes of aging, the prolongation of life span and health in the aged [16].
• Prolongation of life in female NZB/NZW (F1) hybrid mice by cyclosporin A [17].
• Addition of (-)deprenyl to the standard Madopar treatment resulted in an improvement of the disability, in a prolongation of life expectancy, in a reduction of side effects caused by Madopar and a leveling down of the fluctuations in the clinical improvement [18].
• Lower sustained plasma glucose levels may be one of the key factors for prolongation of life [19].
• These results suggested that life prolongation of NKT-01 was produced both by a cytostatic effect, which lasts for an extraordinarily long period, and by a subsequent cytotoxic effect [20].

Gene context of Life Support Care

• Prolongation of life span of dystrophic hamster by cysteine proteinase inhibitor, loxistation (EST) [21].
• New techniques such as non-invasive positive pressure ventilation have resulted in prolongation of life expectancy in CF patients with end-stage lung disease [22].
• CONCLUSIONS: Although the most critical problems were postoperative liver failure and early recurrence, extended surgical treatment should be encouraged for the prolongation of life span and quality of life, when HCC are relatively small and the remnant liver is normal or only fibrotic [23].

Analytical, diagnostic and therapeutic context of Life Support Care

• CONCLUSIONS: Prevention of GVD with simvastatin after heart transplantation was cost effective in all the scenarios examined with impressive prolongation of life expectancy for the heart recipient [24].

References