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MeSH Review

Acupuncture Points

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Disease relevance of Acupuncture Points

  • Intrathecal (i.t.) administration of N/OFQ (15 nmol) or EA at acupoints GB30 and GB34 could significantly attenuate hyperalgesia which was induced by subcutaneously injecting complete Freund's adjuvant (CFA) into one hindpaw of rats, manifesting as decreased paw withdrawal latency (PWL) to the noxious thermal stimulus [1].
  • MS for 7 days beginning on postnatal day 14 induced a significant decrease in body weight and locomotion, while acupuncture treatment at acupoint Shenmen (HT7) resulted in a significant increase in both [2].
  • CONCLUSION: Stimulation of the P6 acupoint with capsicum plaster is an effective method for prevention of PONV after middle ear surgery and its efficacy is comparable to ondansetron for the first six hours after surgery [3].
  • Moreover, electroacupuncture (EA) at special abdominal acupoints has been shown to induce a short-term hypoglycemia effect in streptozotocin diabetic rats [4].

High impact information on Acupuncture Points

  • The observed high-frequency acupoint stimulation effects of Theta EEG were only present during, but not after, simulation [5].
  • In addition to an increase in plasma beta-endorphin-like immunoreactivity, the plasma glucose lowering action of electroacupuncture stimulation at Zhongwan acupoint was abolished by naloxone in a sufficient dose to block opioid receptors [6].
  • RESULTS: Incidence of nausea in the PACU was significantly lower in the acupoint group as compared with the sham point group (32% vs. 56%, P = 0.029) and P6 sham group (32% vs. 64%, P = 0.002) but not as compared with the droperidol group (32% vs. 46%, P = ns) [7].
  • Finally, significantly fewer subjects in the acupoint group required intravenous ondansetron as an initial rescue therapy (P = 0.024) [7].
  • In vivo treatment with neutralizing monoclonal antibody against mouse IFN-gamma completely abrogated the increase in splenic NK cell activity induced by ST36 acupoint stimulation [8].

Anatomical context of Acupuncture Points


Associations of Acupuncture Points with chemical compounds

  • Therefore, we suggest that serotonin also involved in the hypoglycemic action of 2 Hz EA at both zusanli acupoints of normal rats [11].
  • These results provided strong evidence that stimulation of the specific acupoint HT7 helps to normalize the release of dopamine in the mesolimbic system following chronic ethanol treatment [12].
  • There was no sharp hypoglycemic response to 2 Hz EA at zusanli acupoint of STZ-induced diabetic rats [11].
  • The goal of the present study was to determine whether bee venom (BV) injection into the Zhongwan acupoint (CV12), compared to injection into a non-acupoint, produced antinociception in an acetic acid-induced visceral pain model [13].
  • On Control day, electrodes were positioned near the acupoints, but needles were not inserted [14].

Gene context of Acupuncture Points

  • BV acupoint stimulation significantly increased Fos-TH double-labeled neurons in the Arc, LC and DR [15].
  • Fos-DBH positive neurons were also increased by BV acupoint stimulation in the LC and A5 [15].
  • The TNF-alpha, IL-1beta and IL-6 positive cells in the immunohistological sections of subchondral bone region of the joint significantly decreased in HP-treated (ST36 acupoint) arthritic group as compared with those in non-treated or HP-treated (non-acupoint) ones, which was coincident with the behavioral studies [16].
  • COX-2 expression in these two locations were intensified by pregnancy, but reduced by acupuncture at the Sp-6 acupoint [17].
  • The activity of the Theta power significantly decreased (P = 0.02), compared with control during HF but not LF stimulation at acupoint stimulation, however, there was no study effect at the mock point [5].

Analytical, diagnostic and therapeutic context of Acupuncture Points


  1. Involvement of nociceptin/orphanin FQ and its receptor in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammation. Fu, X., Wang, Y.Q., Wu, G.C. Brain Res. (2006) [Pubmed]
  2. Acupuncture increases neuropeptide Y expression in hippocampus of maternally-separated rats. Lim, S., Ryu, Y.H., Kim, S.T., Hong, M.S., Park, H.J. Neurosci. Lett. (2003) [Pubmed]
  3. Prevention of PONV by acustimulation with capsicum plaster is comparable to ondansetron after middle ear surgery. Misra, M.N., Pullani, A.J., Mohamed, Z.U. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (2005) [Pubmed]
  4. Dynamic change in energy metabolism by electroacupuncture stimulation in rats. Tseng, C.S., Shen, W.C., Cheng, F.C., Chen, G.W., Li, T.C., Hsieh, C.L. Am. J. Chin. Med. (2005) [Pubmed]
  5. Mode and site of acupuncture modulation in the human brain: 3D (124-ch) EEG power spectrum mapping and source imaging. Chen, A.C., Liu, F.J., Wang, L., Arendt-Nielsen, L. Neuroimage (2006) [Pubmed]
  6. An insulin-dependent hypoglycaemia induced by electroacupuncture at the Zhongwan (CV12) acupoint in diabetic rats. Chang, S.L., Lin, J.G., Chi, T.C., Liu, I.M., Cheng, J.T. Diabetologia (1999) [Pubmed]
  7. P6 acupoint injections are as effective as droperidol in controlling early postoperative nausea and vomiting in children. Wang, S.M., Kain, Z.N. Anesthesiology (2002) [Pubmed]
  8. Role of endogenous interferon-gamma on the enhancement of splenic NK cell activity by electroacupuncture stimulation in mice. Yu, Y., Kasahara, T., Sato, T., Asano, K., Yu, G., Fang, J., Guo, S., Sahara, M., Hisamitsu, T. J. Neuroimmunol. (1998) [Pubmed]
  9. Release of beta-endorphin from adrenal gland to lower plasma glucose by the electroacupuncture at Zhongwan acupoint in rats. Lin, J.G., Chang, S.L., Cheng, J.T. Neurosci. Lett. (2002) [Pubmed]
  10. Acupuncture-mediated inhibition of ethanol-induced dopamine release in the rat nucleus accumbens through the GABAB receptor. Yoon, S.S., Kwon, Y.K., Kim, M.R., Shim, I., Kim, K.J., Lee, M.H., Lee, Y.S., Golden, G.T., Yang, C.H. Neurosci. Lett. (2004) [Pubmed]
  11. Involvement of serotonin in the hypoglycemic response to 2 Hz electroacupuncture of zusanli acupoint (ST36) in rats. Chang, S.L., Tsai, C.C., Lin, J.G., Hsieh, C.L., Lin, R.T., Cheng, J.T. Neurosci. Lett. (2005) [Pubmed]
  12. Acupuncture normalizes the release of accumbal dopamine during the withdrawal period and after the ethanol challenge in chronic ethanol-treated rats. Zhao, R.J., Yoon, S.S., Lee, B.H., Kwon, Y.K., Kim, K.J., Shim, I., Choi, K.H., Kim, M.R., Golden, G.T., Yang, C.H. Neurosci. Lett. (2006) [Pubmed]
  13. Visceral antinociception produced by bee venom stimulation of the Zhongwan acupuncture point in mice: role of alpha(2) adrenoceptors. Kwon, Y.B., Kang, M.S., Han, H.J., Beitz, A.J., Lee, J.H. Neurosci. Lett. (2001) [Pubmed]
  14. The timing of acupuncture stimulation does not influence anesthetic requirement. Chernyak, G., Sengupta, P., Lenhardt, R., Liem, E., Doufas, A.G., Sessler, D.I., Akça, O. Anesth. Analg. (2005) [Pubmed]
  15. Bee venom acupoint stimulation increases Fos expression in catecholaminergic neurons in the rat brain. Kwon, Y.B., Han, H.J., Beitz, A.J., Lee, J.H. Mol. Cells (2004) [Pubmed]
  16. Therapeutic effects of Hominis placenta injection into an acupuncture point on the inflammatory responses in subchondral bone region of adjuvant-induced polyarthritic rat. Yeom, M.J., Lee, H.C., Kim, G.H., Shim, I., Lee, H.J., Hahm, D.H. Biol. Pharm. Bull. (2003) [Pubmed]
  17. Immunohistochemical localization of cyclooxygenase-2 in pregnant rat uterus by Sp-6 acupuncture. Kim, J.S., Na, C.S., Hwang, W.J., Lee, B.C., Shin, K.H., Pak, S.C. Am. J. Chin. Med. (2003) [Pubmed]
  18. Comparison of P6 acupoint injection with 50% glucose in water and intravenous droperidol for prevention of vomiting after gynecological laparoscopy. Yang, L.C., Jawan, B., Chen, C.N., Ho, R.T., Chang, K.A., Lee, J.H. Acta anaesthesiologica Scandinavica. (1993) [Pubmed]
  19. Effect of moxibustion at acupoints Ren-12 (Zhongwan), St-25 (Tianshu), and St-36 (Zuzanli) in the prevention of gastric lesions induced by indomethacin in Wistar rats. Freire, A.O., Sugai, G.C., Blanco, M.M., Tabosa, A., Yamamura, Y., Mello, L.E. Dig. Dis. Sci. (2005) [Pubmed]
  20. Electric stimulation of acupoints in alleviating hemogram abnormality due to cyclophosphamide injection in animals. Niu, H.T., Lu, X.Y., Zhang, S.F. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine. (1988) [Pubmed]
  21. Effectiveness of acupressure in improving dyspnoea in chronic obstructive pulmonary disease. Wu, H.S., Wu, S.C., Lin, J.G., Lin, L.C. Journal of advanced nursing. (2004) [Pubmed]
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