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MeSH Review

Purpura, Thrombotic Thrombocytopenic

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Disease relevance of Purpura, Thrombotic Thrombocytopenic


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Biological context of Purpura, Thrombotic Thrombocytopenic


Anatomical context of Purpura, Thrombotic Thrombocytopenic


Gene context of Purpura, Thrombotic Thrombocytopenic


Analytical, diagnostic and therapeutic context of Purpura, Thrombotic Thrombocytopenic


  1. von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome. Furlan, M., Robles, R., Galbusera, M., Remuzzi, G., Kyrle, P.A., Brenner, B., Krause, M., Scharrer, I., Aumann, V., Mittler, U., Solenthaler, M., Lämmle, B. N. Engl. J. Med. (1998) [Pubmed]
  2. Neurological manifestations of systemic lupus erythematosus and thrombotic thrombocytopenic purpura.. Petz, L.D. Stroke (1977) [Pubmed]
  3. Development and assessment of enzyme immunoassay for platelet-derived microparticles. Osumi, K., Ozeki, Y., Saito, S., Nagamura, Y., Ito, H., Kimura, Y., Ogura, H., Nomura, S. Thromb. Haemost. (2001) [Pubmed]
  4. Protein C levels in disseminated intravascular coagulation and thrombotic thrombocytopenic purpura: its correlation with other coagulation parameters. Takahashi, H., Takakuwa, E., Yoshino, N., Hanano, M., Shibata, A. Thromb. Haemost. (1985) [Pubmed]
  5. Endothelin: a possible role in the occurrence of renal failure in thrombotic thrombocytopenic purpura. Spooren, P.F., Vermes, I., Kip, L., Haanen, C. Thromb. Haemost. (1993) [Pubmed]
  6. Thrombotic thrombocytopenic purpura associated with clopidogrel. Bennett, C.L., Connors, J.M., Carwile, J.M., Moake, J.L., Bell, W.R., Tarantolo, S.R., McCarthy, L.J., Sarode, R., Hatfield, A.J., Feldman, M.D., Davidson, C.J., Tsai, H.M. N. Engl. J. Med. (2000) [Pubmed]
  7. Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Levy, G.G., Nichols, W.C., Lian, E.C., Foroud, T., McClintick, J.N., McGee, B.M., Yang, A.Y., Siemieniak, D.R., Stark, K.R., Gruppo, R., Sarode, R., Shurin, S.B., Chandrasekaran, V., Stabler, S.P., Sabio, H., Bouhassira, E.E., Upshaw, J.D., Ginsburg, D., Tsai, H.M. Nature (2001) [Pubmed]
  8. Incidence and clinical course of thrombotic thrombocytopenic purpura due to ticlopidine following coronary stenting. EPISTENT Investigators. Evaluation of Platelet IIb/IIIa Inhibitor for Stenting. Steinhubl, S.R., Tan, W.A., Foody, J.M., Topol, E.J. JAMA (1999) [Pubmed]
  9. Ineffective epoprostenol therapy for thrombotic thrombocytopenic purpura. Johnson, J.E., Mills, G.M., Batson, A.G., Cato, A.E., Thornsvard, C.T. JAMA (1983) [Pubmed]
  10. Ticlopidine and thrombotic thrombocytopenic purpura. Kupfer, Y., Tessler, S. N. Engl. J. Med. (1997) [Pubmed]
  11. Thrombotic thrombocytopenic purpura: onset during dipyridamole therapy. Lindquist, J.R., George, R.P. JAMA (1981) [Pubmed]
  12. Cyclophosphamide for chronic relapsing thrombotic thrombocytopenic purpura. Udvardy, M., Rak, K. Lancet (1990) [Pubmed]
  13. Remission after 13-cis retinoic acid in thrombotic thrombocytopenic purpura. Raife, T.J., McArthur, J., Peters, C., Kisker, C.T., Lentz, S.R. Lancet (1998) [Pubmed]
  14. Nafazatrom in treatment of thrombotic thrombocytopenic purpura. Durrant, S.T., Joosten, P., Gordon-Smith, E.C. Lancet (1985) [Pubmed]
  15. Thrombotic thrombocytopenic purpura associated with ticlopidine. A review of 60 cases. Bennett, C.L., Weinberg, P.D., Rozenberg-Ben-Dror, K., Yarnold, P.R., Kwaan, H.C., Green, D. Ann. Intern. Med. (1998) [Pubmed]
  16. Studies investigating platelet aggregation and release initiated by sera from patients with thrombotic thrombocytopenic purpura. Kelton, J.G., Moore, J.C., Murphy, W.G. Blood (1987) [Pubmed]
  17. Molecular characterization of ADAMTS13 gene mutations in Japanese patients with Upshaw-Schulman syndrome. Matsumoto, M., Kokame, K., Soejima, K., Miura, M., Hayashi, S., Fujii, Y., Iwai, A., Ito, E., Tsuji, Y., Takeda-Shitaka, M., Iwadate, M., Umeyama, H., Yagi, H., Ishizashi, H., Banno, F., Nakagaki, T., Miyata, T., Fujimura, Y. Blood (2004) [Pubmed]
  18. Congenital microangiopathic hemolytic anemia and thrombocytopenia with unusually large von Willebrand factor multimers and von Willebrand factor-cleaving protease. Savaşan, S., Taub, J.W., Buck, S., Botterill, M., Furlan, M., Ravindranath, Y. J. Pediatr. Hematol. Oncol. (2001) [Pubmed]
  19. Fibrinolysis in health and disease: abnormal levels of plasminogen activator, plasminogen activator inhibitor, and protein C in thrombotic thrombocytopenic purpura. Glas-Greenwalt, P., Hall, J.M., Panke, T.W., Kant, K.S., Allen, C.M., Pollak, V.E. J. Lab. Clin. Med. (1986) [Pubmed]
  20. Effects of fresh-frozen plasma and its cryosupernatant fraction on von Willebrand factor multimeric forms in chronic relapsing thrombotic thrombocytopenic purpura. Moake, J.L., Byrnes, J.J., Troll, J.H., Rudy, C.K., Hong, S.L., Weinstein, M.J., Colannino, N.M. Blood (1985) [Pubmed]
  21. Cyclosporin for thrombotic thrombocytopenic purpura after autologous bone marrow transplantation. van Ojik, H., Biesma, D.H., Fijnheer, R., Hené, R.J., Lokhorst, H.M., Rooda, S.J., Verdonck, L.F. Br. J. Haematol. (1997) [Pubmed]
  22. Heparin-induced thrombocytopenia antibody and the pathogenesis of thrombotic microangiopathy after stem cell transplantation. Takatsuka, H., Nakajima, T., Nomura, K., Wakae, T., Toda, A., Itoi, H., Okada, M., Misawa, M., Hara, H. Clinical transplantation. (2005) [Pubmed]
  23. Endothelial microparticles correlate with high-risk angiographic lesions in acute coronary syndromes. Bernal-Mizrachi, L., Jy, W., Fierro, C., Macdonough, R., Velazques, H.A., Purow, J., Jimenez, J.J., Horstman, L.L., Ferreira, A., de Marchena, E., Ahn, Y.S. International journal of cardiology. (2004) [Pubmed]
  24. Systemic antithrombotic effects of ADAMTS13. Chauhan, A.K., Motto, D.G., Lamb, C.B., Bergmeier, W., Dockal, M., Plaimauer, B., Scheiflinger, F., Ginsburg, D., Wagner, D.D. J. Exp. Med. (2006) [Pubmed]
  25. Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13. Bonnefoy, A., Daenens, K., Feys, H.B., De Vos, R., Vandervoort, P., Vermylen, J., Lawler, J., Hoylaerts, M.F. Blood (2006) [Pubmed]
  26. Increased plasma thrombomodulin as a vascular endothelial cell marker in patients with thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Mori, Y., Wada, H., Okugawa, Y., Tamaki, S., Nakasaki, T., Watanabe, R., Gabazza, E.C., Nishikawa, M., Minami, N., Shiku, H. Clin. Appl. Thromb. Hemost. (2001) [Pubmed]
  27. von Willebrand factor: two sides of a coin. Sadler, J.E. J. Thromb. Haemost. (2005) [Pubmed]
  28. Platelet-agglutinating protein p37 from a thrombotic thrombocytopenic purpura plasma forms complexes with platelet membrane glycoprotein IV (CD36). Siddiqui, F.A., Lian, E.C. Biochem. Int. (1992) [Pubmed]
  29. Thrombotic thrombocytopenic purpura: combined treatment with plasmapheresis and antiplatelet agents. Myers, T.J., Wakem, C.J., Ball, E.D., Tremont, S.J. Ann. Intern. Med. (1980) [Pubmed]
  30. Phagocytosis of blood cells by splenic macrophages in thrombotic thrombocytopenic purpura. Kadri, A., Noinuddin, M., de Leeuw, N.K. Ann. Intern. Med. (1975) [Pubmed]
  31. Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura. Zheng, X.L., Kaufman, R.M., Goodnough, L.T., Sadler, J.E. Blood (2004) [Pubmed]
  32. Epitope mapping of ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura. Klaus, C., Plaimauer, B., Studt, J.D., Dorner, F., Lämmle, B., Mannucci, P.M., Scheiflinger, F. Blood (2004) [Pubmed]
  33. An enzyme immunoassay of ADAMTS13 distinguishes patients with thrombotic thrombocytopenic purpura from normal individuals and carriers of ADAMTS13 mutations. Zhou, W., Tsai, H.M. Thromb. Haemost. (2004) [Pubmed]
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