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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Pregnancy Maintenance

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Disease relevance of Pregnancy Maintenance


High impact information on Pregnancy Maintenance

  • Hence, our data shed light on a hierarchical network of immune integration at the feto-maternal interface, in which ICAM-1/LFA-1 cross talk is clearly a proximate mediator capable of disrupting successful pregnancy maintenance [3].
  • Plasma levels of the endocannabinoid anandamide in women--a potential role in pregnancy maintenance and labor [4]?
  • Like its human counterpart hCG-beta with which it shares 81% identity, macaque (m)CG-beta is a cystine knot-containing subunit that assembles with an alpha-subunit common to all glycoprotein hormone members of its species to form a biologically active heterodimer, mCG, which, like hCG, is required for pregnancy maintenance [5].
  • In two in vivo rodent models of progestational activity, a pregnancy maintenance assay and a uterine wet weight assay, the two eutomers displayed potent progesterone-like effects [6].
  • Thus, steroid-induced hypertrophied placentae in rats do not participate in a compensatory mechanism for steroid hormone production toward pregnancy maintenance [7].

Biological context of Pregnancy Maintenance


Anatomical context of Pregnancy Maintenance

  • OBJECTIVE: To review the literature on the roles of thyroid hormone in trophoblast function, early pregnancy maintenance, and fetal neurodevelopment [12].
  • PROBLEM: We previously reported a diminished expression of the heme-degrading enzymes heme oxygenases (HO)-1 and HO-2 in decidua and placenta from mice undergoing Th1-mediated abortion, strongly indicating the protective effect of HO in murine pregnancy maintenance [13].

Associations of Pregnancy Maintenance with chemical compounds


Gene context of Pregnancy Maintenance


Analytical, diagnostic and therapeutic context of Pregnancy Maintenance


  1. Gene-environment interactions: a review of effects on reproduction and development. Cummings, A.M., Kavlock, R.J. Crit. Rev. Toxicol. (2004) [Pubmed]
  2. Oral micronized progesterone. Bioavailability pharmacokinetics, pharmacological and therapeutic implications--a review. Sitruk-Ware, R., Bricaire, C., De Lignieres, B., Yaneva, H., Mauvais-Jarvis, P. Contraception. (1987) [Pubmed]
  3. Intercellular adhesion molecule-1/LFA-1 cross talk is a proximate mediator capable of disrupting immune integration and tolerance mechanism at the feto-maternal interface in murine pregnancies. Blois, S., Tometten, M., Kandil, J., Hagen, E., Klapp, B.F., Margni, R.A., Arck, P.C. J. Immunol. (2005) [Pubmed]
  4. Plasma levels of the endocannabinoid anandamide in women--a potential role in pregnancy maintenance and labor? Habayeb, O.M., Taylor, A.H., Evans, M.D., Cooke, M.S., Taylor, D.J., Bell, S.C., Konje, J.C. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  5. Disulfide bond rearrangement during formation of the chorionic gonadotropin beta-subunit cystine knot in vivo. Wilken, J.A., Bedows, E. Biochemistry (2004) [Pubmed]
  6. Preparation, resolution, and biological evaluation of 5-aryl-1, 2-dihydro-5H-chromeno[3,4-f]quinolines: potent, orally active, nonsteroidal progesterone receptor agonists. Edwards, J.P., Zhi, L., Pooley, C.L., Tegley, C.M., West, S.J., Wang, M.W., Gottardis, M.M., Pathirana, C., Schrader, W.T., Jones, T.K. J. Med. Chem. (1998) [Pubmed]
  7. Placental steriodogenesis in the rat: comparison of normal and giant placentae. Chan, S.W., Leathem, J.H. Endocrinology (1977) [Pubmed]
  8. The Krüppel-like core promoter binding protein gene is primarily expressed in placenta during mouse development. Slavin, D., Sapin, V., López-Diaz, F., Jacquemin, P., Koritschoner, N., Dastugue, B., Davidson, I., Chatton, B., Bocco, J.L. Biol. Reprod. (1999) [Pubmed]
  9. Studies on the localization of 5-hydroxytryptamine and its receptors in human placenta. Huang, W.Q., Zhang, C.L., Di, X.Y., Zhang, R.Q. Placenta (1998) [Pubmed]
  10. Prostaglandins and the myometrium and cervix. Hertelendy, F., Zakár, T. Prostaglandins Leukot. Essent. Fatty Acids (2004) [Pubmed]
  11. Heme oxygenase is downregulated in stress-triggered and interleukin-12-mediated murine abortion. Zenclussen, A.C., Joachim, R., Hagen, E., Peiser, C., Klapp, B.F., Arck, P.C. Scand. J. Immunol. (2002) [Pubmed]
  12. The role of thyroid hormone in trophoblast function, early pregnancy maintenance, and fetal neurodevelopment. Ohara, N., Tsujino, T., Maruo, T. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC. (2004) [Pubmed]
  13. Heme oxygenases in pregnancy II: HO-2 is downregulated in human pathologic pregnancies. Zenclussen, A.C., Lim, E., Knoeller, S., Knackstedt, M., Hertwig, K., Hagen, E., Klapp, B.F., Arck, P.C. Am. J. Reprod. Immunol. (2003) [Pubmed]
  14. Altered fetal pituitary-adrenal function in the ovine fetus treated with RU486 and meloxicam, an inhibitor of prostaglandin synthase-II. McKeown, K.J., Challis, J.R., Small, C., Adamson, L., Bocking, A.D., Fraser, M., Rurak, D., Riggs, K.W., Lye, S.J. Biol. Reprod. (2000) [Pubmed]
  15. Proceedings: Effects of medroxyprogesterone acetate and oestradiol-17beta on pregnancy maintenance in ovariectomized rats. Bruce, N.W., Bartholoneusz, R.K. J. Reprod. Fertil. (1976) [Pubmed]
  16. Synthesis and biological activity of a new progestogen, 16-methylene-17alpha-hydroxy-18-methyl-19-norpregn-4-ene-3, 20-dione acetate. Tuba, Z., Bardin, C.W., Dancsi, A., Francsics-Czinege, E., Molnár, C., Csörgei, J., Falkay, G., Koide, S.S., Kumar, N., Sundaram, K., Dukát-Abrók, V., Balogh, G. Steroids (2000) [Pubmed]
  17. Effect of excess dietary methionine on rat pregnancy: influence on ovarian delta5-3beta-hydroxysteroid dehydrogenase activity. Chandrashekar, V., Leathem, J.H. Fertil. Steril. (1977) [Pubmed]
  18. The role of estrogen in the maintenance of primate pregnancy. Albrecht, E.D., Aberdeen, G.W., Pepe, G.J. Am. J. Obstet. Gynecol. (2000) [Pubmed]
  19. Expression of membrane-bound HLA-G at the maternal-fetal interface is not associated with pregnancy maintenance among patients with idiopathic recurrent pregnancy loss. Patel, R.N., Quack, K.C., Hill, J.A., Schust, D.J. Mol. Hum. Reprod. (2003) [Pubmed]
  20. Mifepristone (Ru486) antagonizes monocyte chemotactic protein-3 down-regulation at early mouse pregnancy revealing immunomodulatory events in Ru486 induced abortion. Nautiyal, J., Kumar, P.G., Laloraya, M. Am. J. Reprod. Immunol. (2004) [Pubmed]
  21. Relaxin secretion in early pregnancy. Quagliarello, J., Steinetz, B.G., Weiss, G. Obstetrics and gynecology. (1979) [Pubmed]
  22. Effect of atrazine on implantation and early pregnancy in 4 strains of rats. Cummings, A.M., Rhodes, B.E., Cooper, R.L. Toxicol. Sci. (2000) [Pubmed]
  23. Inducible nitric oxide synthase is present in the rat placenta at the fetal-maternal interface and decreases prior to labour. Purcell, T.L., Buhimschi, I.A., Given, R., Chwalisz, K., Garfield, R.E. Mol. Hum. Reprod. (1997) [Pubmed]
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