Gene Review:
Hmox2 - heme oxygenase (decycling) 2
Mus musculus
Synonyms:
HO-2, HO2, Heme oxygenase 2
- Effect of targeted deletion of the heme oxygenase-2 gene on hemoglobin toxicity in the striatum. Qu, Y., Chen, J., Benvenisti-Zarom, L., Ma, X., Regan, R.F. J. Cereb. Blood Flow Metab. (2005)
- Attenuation of oxidative injury after induction of experimental intracerebral hemorrhage in heme oxygenase-2 knockout mice. Qu, Y., Chen-Roetling, J., Benvenisti-Zarom, L., Regan, R.F. J. Neurosurg. (2007)
- Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. Yet, S.F., Perrella, M.A., Layne, M.D., Hsieh, C.M., Maemura, K., Kobzik, L., Wiesel, P., Christou, H., Kourembanas, S., Lee, M.E. J. Clin. Invest. (1999)
- Site of injury-directed induction of heme oxygenase-1 and -2 in experimental spinal cord injury: differential functions in neuronal defense mechanisms? Panahian, N., Maines, M.D. J. Neurochem. (2001)
- Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2. Burnett, A.L., Johns, D.G., Kriegsfeld, L.J., Klein, S.L., Calvin, D.C., Demas, G.E., Schramm, L.P., Tonegawa, S., Nelson, R.J., Snyder, S.H., Poss, K.D. Nat. Med. (1998)
- Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2. Boehning, D., Moon, C., Sharma, S., Hurt, K.J., Hester, L.D., Ronnett, G.V., Shugar, D., Snyder, S.H. Neuron (2003)
- Hypoxemia and blunted hypoxic ventilatory responses in mice lacking heme oxygenase-2. Adachi, T., Ishikawa, K., Hida, W., Matsumoto, H., Masuda, T., Date, F., Ogawa, K., Takeda, K., Furuyama, K., Zhang, Y., Kitamuro, T., Ogawa, H., Maruyama, Y., Shibahara, S. Biochem. Biophys. Res. Commun. (2004)
- Heme oxygenase-2 acts to prevent neuronal death in brain cultures and following transient cerebral ischemia. Doré, S., Goto, S., Sampei, K., Blackshaw, S., Hester, L.D., Ingi, T., Sawa, A., Traystman, R.J., Koehler, R.C., Snyder, S.H. Neuroscience (2000)
- Heme oxygenase-2 deficiency contributes to diabetes-mediated increase in superoxide anion and renal dysfunction. Goodman, A.I., Chander, P.N., Rezzani, R., Schwartzman, M.L., Regan, R.F., Rodella, L., Turkseven, S., Lianos, E.A., Dennery, P.A., Abraham, N.G. J. Am. Soc. Nephrol. (2006)
- Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: contributions of HO-1 and HO-2 to cytoprotection. Parfenova, H., Basuroy, S., Bhattacharya, S., Tcheranova, D., Qu, Y., Regan, R.F., Leffler, C.W. Am. J. Physiol., Cell Physiol. (2006)
- Heme oxygenase-1 and heme oxygenase-2 have distinct roles in the proliferation and survival of olfactory receptor neurons mediated by cGMP and bilirubin, respectively. Chen, J., Tu, Y., Moon, C., Nagata, E., Ronnett, G.V. J. Neurochem. (2003)
- Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2. Dennery, P.A., Spitz, D.R., Yang, G., Tatarov, A., Lee, C.S., Shegog, M.L., Poss, K.D. J. Clin. Invest. (1998)
- Heme oxygenase-2 is neuroprotective in cerebral ischemia. Doré, S., Sampei, K., Goto, S., Alkayed, N.J., Guastella, D., Blackshaw, S., Gallagher, M., Traystman, R.J., Hurn, P.D., Koehler, R.C., Snyder, S.H. Mol. Med. (1999)
- Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury. Chang, E.F., Wong, R.J., Vreman, H.J., Igarashi, T., Galo, E., Sharp, F.R., Stevenson, D.K., Noble-Haeusslein, L.J. J. Neurosci. (2003)
- Spinal cord nitric oxide synthase and heme oxygenase limit morphine induced analgesia. Li, X., Clark, J.D. Brain Res. Mol. Brain Res. (2001)
- Carbon monoxide mediates vasoactive intestinal polypeptide-associated nonadrenergic/noncholinergic neurotransmission. Watkins, C.C., Boehning, D., Kaplin, A.I., Rao, M., Ferris, C.D., Snyder, S.H. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonists: correlation with induction of heme oxygenase 1. Colville-Nash, P.R., Qureshi, S.S., Willis, D., Willoughby, D.A. J. Immunol. (1998)
- Regional distribution of heme oxygenase, HSP70, and glutathione in brain: relevance for endogenous oxidant/antioxidant balance and stress tolerance. Calabrese, V., Scapagnini, G., Ravagna, A., Fariello, R.G., Giuffrida Stella, A.M., Abraham, N.G. J. Neurosci. Res. (2002)
- Heme oxygenase type 2 participates in the development of chronic inflammatory and neuropathic pain. Li, X., Clark, J.D. The journal of pain : official journal of the American Pain Society. (2003)
- Expression and regulation of heme oxygenase isozymes in the developing mouse cortex. Zhao, H., Wong, R.J., Nguyen, X., Kalish, F., Mizobuchi, M., Vreman, H.J., Stevenson, D.K., Contag, C.H. Pediatr. Res. (2006)
- Heme oxygenase is downregulated in stress-triggered and interleukin-12-mediated murine abortion. Zenclussen, A.C., Joachim, R., Hagen, E., Peiser, C., Klapp, B.F., Arck, P.C. Scand. J. Immunol. (2002)