Gene Review:
CA9 - carbonic anhydrase IX
Homo sapiens
Synonyms:
CA-IX, CAIX, Carbonate dehydratase IX, Carbonic anhydrase 9, Carbonic anhydrase IX, ...
Watson,
Chia,
Wykoff,
Han,
Leek,
Sly,
Gatter,
Ratcliffe,
Harris,
Kuijper,
van der Groep,
van der Wall,
van Diest,
Ivanov,
Liao,
Ivanova,
Danilkovitch-Miagkova,
Tarasova,
Weirich,
Merrill,
Proescholdt,
Oldfield,
Lee,
Zavada,
Waheed,
Sly,
Lerman,
Stanbridge,
Ivanov,
Kuzmin,
Wei,
Pack,
Geil,
Johnson,
Stanbridge,
Lerman,
Said,
Staab,
Hagemann,
Vince,
Katzer,
Flentje,
Vordermark,
Pastorekova,
Parkkila,
Zavada,
Staehler,
Rohrmann,
Haseke,
Stief,
Siebels,
Blackwell,
Dewhirst,
Liotcheva,
Snyder,
Broadwater,
Bentley,
Lal,
Riggins,
Anderson,
Vredenburgh,
Proia,
Harris,
Saarnio,
Parkkila,
Parkkila,
Haukipuro,
Pastoreková,
Pastorek,
Kairaluoma,
Karttunen,
- Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Wykoff, C.C., Beasley, N.J., Watson, P.H., Turner, K.J., Pastorek, J., Sibtain, A., Wilson, G.D., Turley, H., Talks, K.L., Maxwell, P.H., Pugh, C.W., Ratcliffe, P.J., Harris, A.L. Cancer Res. (2000)
- Carbonic anhydrase XII is a marker of good prognosis in invasive breast carcinoma. Watson, P.H., Chia, S.K., Wykoff, C.C., Han, C., Leek, R.D., Sly, W.S., Gatter, K.C., Ratcliffe, P., Harris, A.L. Br. J. Cancer (2003)
- Expression of hypoxia-related tissue factors in astrocytic gliomas. A multivariate survival study with emphasis upon carbonic anhydrase IX. Korkolopoulou, P., Perdiki, M., Thymara, I., Boviatsis, E., Agrogiannis, G., Kotsiakis, X., Angelidakis, D., Rologis, D., Diamantopoulou, K., Thomas-Tsagli, E., Kaklamanis, L., Gatter, K., Patsouris, E. Hum. Pathol. (2007)
- Immunohistochemical detection of osteopontin in advanced head-and-neck cancer: Prognostic role and correlation with oxygen electrode measurements, hypoxia-inducible-factor-1alpha-related markers, and hemoglobin levels. Bache, M., Reddemann, R., Said, H.M., Holzhausen, H.J., Taubert, H., Becker, A., Kuhnt, T., H??nsgen, G., Dunst, J., Vordermark, D. Int. J. Radiat. Oncol. Biol. Phys. (2006)
- A single amino acid interchange yields reciprocal CTL specificities for HIV-1 gp160. Takahashi, H., Merli, S., Putney, S.D., Houghten, R., Moss, B., Germain, R.N., Berzofsky, J.A. Science (1989)
- Carbonic anhydrase IX, MN/CA IX: analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts. Pastoreková, S., Parkkila, S., Parkkila, A.K., Opavský, R., Zelník, V., Saarnio, J., Pastorek, J. Gastroenterology (1997)
- Induction by hypoxia combined with low glucose or low bicarbonate and high posttranslational stability upon reoxygenation contribute to carbonic anhydrase IX expression in cancer cells. Rafajová, M., Zatovicová, M., Kettmann, R., Pastorek, J., Pastoreková, S. Int. J. Oncol. (2004)
- Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation. Saarnio, J., Parkkila, S., Parkkila, A.K., Haukipuro, K., Pastoreková, S., Pastorek, J., Kairaluoma, M.I., Karttunen, T.J. Am. J. Pathol. (1998)
- Distinct patterns of hypoxic expression of carbonic anhydrase IX (CA IX) in human malignant glioma cell lines. Said, H.M., Staab, A., Hagemann, C., Vince, G.H., Katzer, A., Flentje, M., Vordermark, D. J. Neurooncol. (2007)
- Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment. Pastorek, J., Pastoreková, S., Callebaut, I., Mornon, J.P., Zelník, V., Opavský, R., Zat'ovicová, M., Liao, S., Portetelle, D., Stanbridge, E.J. Oncogene (1994)
- Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes. Ivanov, S.V., Kuzmin, I., Wei, M.H., Pack, S., Geil, L., Johnson, B.E., Stanbridge, E.J., Lerman, M.I. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Human MN/CA9 gene, a novel member of the carbonic anhydrase family: structure and exon to protein domain relationships. Opavský, R., Pastoreková, S., Zelník, V., Gibadulinová, A., Stanbridge, E.J., Závada, J., Kettmann, R., Pastorek, J. Genomics (1996)
- Effects of von Hippel-Lindau gene mutation and methylation status on expression of transmembrane carbonic anhydrases in renal cell carcinoma. Ashida, S., Nishimori, I., Tanimura, M., Onishi, S., Shuin, T. J. Cancer Res. Clin. Oncol. (2002)
- Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. Ivanov, S., Liao, S.Y., Ivanova, A., Danilkovitch-Miagkova, A., Tarasova, N., Weirich, G., Merrill, M.J., Proescholdt, M.A., Oldfield, E.H., Lee, J., Zavada, J., Waheed, A., Sly, W., Lerman, M.I., Stanbridge, E.J. Am. J. Pathol. (2001)
- Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa. Kivela, A.J., Parkkila, S., Saarnio, J., Karttunen, T.J., Kivela, J., Parkkila, A.K., Bartosova, M., Mucha, V., Novak, M., Waheed, A., Sly, W.S., Rajaniemi, H., Pastorekova, S., Pastorek, J. World J. Gastroenterol. (2005)
- Expression of hypoxia-inducible factor 1 alpha and its downstream targets in fibroepithelial tumors of the breast. Kuijper, A., van der Groep, P., van der Wall, E., van Diest, P.J. Breast Cancer Res. (2005)
- Hypoxia in human colorectal adenocarcinoma: Comparison between extrinsic and potential intrinsic hypoxia markers. Goethals, L., Debucquoy, A., Perneel, C., Geboes, K., Ectors, N., De Schutter, H., Penninckx, F., McBride, W.H., Begg, A.C., Haustermans, K.M. Int. J. Radiat. Oncol. Biol. Phys. (2006)
- The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer. Turner, K.J., Crew, J.P., Wykoff, C.C., Watson, P.H., Poulsom, R., Pastorek, J., Ratcliffe, P.J., Cranston, D., Harris, A.L. Br. J. Cancer (2002)
- Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Nishimori, I., Vullo, D., Innocenti, A., Scozzafava, A., Mastrolorenzo, A., Supuran, C.T. Bioorg. Med. Chem. Lett. (2005)
- Targeted agents for the treatment of advanced renal cell carcinoma. Staehler, M., Rohrmann, K., Haseke, N., Stief, C.G., Siebels, M. Current drug targets. (2005)
- Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia. Ihnatko, R., Kubes, M., Takacova, M., Sedlakova, O., Sedlak, J., Pastorek, J., Kopacek, J., Pastorekova, S. Int. J. Oncol. (2006)
- Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with beta-catenin. Svastová, E., Zilka, N., Zat'ovicová, M., Gibadulinová, A., Ciampor, F., Pastorek, J., Pastoreková, S. Exp. Cell Res. (2003)
- DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX. Kaluzová, M., Kaluz, S., Lerman, M.I., Stanbridge, E.J. Mol. Cell. Biol. (2004)
- MAPK pathway contributes to density- and hypoxia-induced expression of the tumor-associated carbonic anhydrase IX. Kopacek, J., Barathova, M., Dequiedt, F., Sepelakova, J., Kettmann, R., Pastorek, J., Pastorekova, S. Biochim. Biophys. Acta (2005)
- Tumor-associated carbonic anhydrases and their clinical significance. Pastorekova, S., Parkkila, S., Zavada, J. Advances in clinical chemistry (2006)
- Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase. Kaluz, S., Kaluzová, M., Chrastina, A., Olive, P.L., Pastoreková, S., Pastorek, J., Lerman, M.I., Stanbridge, E.J. Cancer Res. (2002)
- HER-2 gene amplification correlates with higher levels of angiogenesis and lower levels of hypoxia in primary breast tumors. Blackwell, K.L., Dewhirst, M.W., Liotcheva, V., Snyder, S., Broadwater, G., Bentley, R., Lal, A., Riggins, G., Anderson, S., Vredenburgh, J., Proia, A., Harris, L.N. Clin. Cancer Res. (2004)
- Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival. Hui, E.P., Chan, A.T., Pezzella, F., Turley, H., To, K.F., Poon, T.C., Zee, B., Mo, F., Teo, P.M., Huang, D.P., Gatter, K.C., Johnson, P.J., Harris, A.L. Clin. Cancer Res. (2002)
- Expression of vascular endothelial growth factor, hypoxia inducible factor 1alpha, and carbonic anhydrase IX in human tumours. Jubb, A.M., Pham, T.Q., Hanby, A.M., Frantz, G.D., Peale, F.V., Wu, T.D., Koeppen, H.W., Hillan, K.J. J. Clin. Pathol. (2004)
- Vascular endothelial growth factor (VEGF)-A and platelet-derived growth factor (PDGF) play a central role in the pathogenesis of digital clubbing. Atkinson, S., Fox, S.B. J. Pathol. (2004)
- Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates. Winum, J.Y., Vullo, D., Casini, A., Montero, J.L., Scozzafava, A., Supuran, C.T. J. Med. Chem. (2003)