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Chemical Compound Review

BAPN     3-aminopropanenitrile

Synonyms: Lopac-A-3134, PubChem19134, ACMC-1B8B9, CCRIS 8134, AG-G-18109, ...
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Disease relevance of Aminopropionitrile


Psychiatry related information on Aminopropionitrile

  • The BAPN-treated animals showed an increased density of IJs, SAs, and Ids when compared with controls but the NJs demonstrated no change [6].

High impact information on Aminopropionitrile


Chemical compound and disease context of Aminopropionitrile


Biological context of Aminopropionitrile


Anatomical context of Aminopropionitrile


Associations of Aminopropionitrile with other chemical compounds


Gene context of Aminopropionitrile


Analytical, diagnostic and therapeutic context of Aminopropionitrile

  • Pretreatment of animals with beta-aminopropionitrile to inhibit collagen cross-linking caused an 82% decrease in tumor formation and a significant reduction in tumor volume (approximately 0.4 cu cm) compared to controls (approximately 10 cu cm) [2].
  • Western blots of extracted proteins from chick embryonic aortae cultured in the presence of beta-aminopropionitrile showed that the medium and a mild salt extract contained an immunoreactive protein possessing an apparent molecular mass of 58,000 whereas harsh denaturants extracted a 32,000-kDa protein [34].
  • After debanding, the ratio remained lower in the banded group without beta-aminopropionitrile treatment than in the control group [35].
  • BAPN was found in the urine within one hour of oral administration [36].
  • Transmission electron microscopy of the media of the thoracic aorta revealed that the types of intercellular contacts seen in the controls and in the BAPN group were intermediate junctions (IJs), nexus junctions (NJs), simple appositions (SAs), and interdigitations (Ids) as in adult vessels [6].


  1. Reduction of blood pressure and vascular collagen in hypertensive rats by beta-aminopropionitrile. Iwatsuki, K., Cardinale, G.J., Spector, S., Udenfriend, S. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  2. Collagen synthesis in capsules surrounding dimethylbenzanthracene-induced rat breast tumors and the effect of pretreatment with beta-aminopropionitrile. Cohen, I.K., Moncure, C.W., Witorsch, R.J., Diegelmann, R.F. Cancer Res. (1979) [Pubmed]
  3. The effects of beta-aminopropionitrile on the growing rat lung. Kida, K., Thurlbeck, W.M. Am. J. Pathol. (1980) [Pubmed]
  4. Alteration of elastic architecture in the lathyritic rat aorta implies the pathogenesis of aortic dissecting aneurysm. Nakashima, Y., Sueishi, K. Am. J. Pathol. (1992) [Pubmed]
  5. Pharmacologic control of surface scarring in human beings. Peacock, E.E. Ann. Surg. (1981) [Pubmed]
  6. Intercellular contacts in the media of the thoracic aorta of rat fetuses treated with beta-aminopropionitrile. Sosa-Melgarejo, J.A., Berry, C.L. J. Pathol. (1991) [Pubmed]
  7. Localization of lysyl oxidase in hen oviduct: implications in egg shell membrane formation and composition. Harris, E.D., Blount, J.E., Leach, R.M. Science (1980) [Pubmed]
  8. The smooth muscle cell. III. Elastin synthesis in arterial smooth muscle cell culture. Narayanan, A.S., Sandberg, L.B., Ross, R., Layman, D.L. J. Cell Biol. (1976) [Pubmed]
  9. Cell-extracellular matrix interactions under in vivo conditions during interstitial cell migration in Hydra vulgaris. Zhang, X., Sarras, M.P. Development (1994) [Pubmed]
  10. Potentiating effect of beta-aminopropionitrile on the DNA synthesis induced by isoproterenol. Sasaki, T., Yamamoto, M. Cancer Res. (1979) [Pubmed]
  11. Elastic skeleton of intracranial cerebral aneurysms in rats. Yamazoe, N., Hashimoto, N., Kikuchi, H., Hazama, F. Stroke (1990) [Pubmed]
  12. Effect of D-penicillamine and beta-aminopropionitrile on collagen breakdown of carrageenin granuloma in rats. Nakagawa, H., Ohkoshi, K., Tsurufuji, S. Biochem. Pharmacol. (1976) [Pubmed]
  13. Allylamine and beta-aminopropionitrile-induced vascular injury: enhanced expression of high-molecular-weight proteins. Awasthi, S., Boor, P.J. J. Toxicol. Environ. Health Part A (1998) [Pubmed]
  14. Phenytoin inhibition: failure to inhibit periosteal responses to lathyrogen. Fallon, M.D., Yeager, V.L., Taylor, J.L. Arch. Pathol. Lab. Med. (1977) [Pubmed]
  15. Treatment of experimental silicosis with antifibrotic agents. Geismar, L.S., Kerr, J.S., Trelstad, R.L., Riley, D.J. Toxicology (1988) [Pubmed]
  16. Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanism. Payne, S.L., Fogelgren, B., Hess, A.R., Seftor, E.A., Wiley, E.L., Fong, S.F., Csiszar, K., Hendrix, M.J., Kirschmann, D.A. Cancer Res. (2005) [Pubmed]
  17. The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells. Palamakumbura, A.H., Jeay, S., Guo, Y., Pischon, N., Sommer, P., Sonenshein, G.E., Trackman, P.C. J. Biol. Chem. (2004) [Pubmed]
  18. Gastrulation in the sea urchin embryo requires the deposition of crosslinked collagen within the extracellular matrix. Wessel, G.M., McClay, D.R. Dev. Biol. (1987) [Pubmed]
  19. Type XI collagen is a heterotrimer with the composition (1 alpha, 2 alpha, 3 alpha) retaining non-triple-helical domains. Morris, N.P., Bächinger, H.P. J. Biol. Chem. (1987) [Pubmed]
  20. Processing of procollagen types III and I in cultured bovine smooth muscle cells. Gerstenfeld, L., Beldekas, J.C., Sonenshein, G.E., Franzblau, C. J. Biol. Chem. (1984) [Pubmed]
  21. Synergistic vascular toxicity and fatty acid anilides in the toxic oil syndrome. Boor, P.J., Khan, M.F., Kaphalia, B.S., Jerrells, T.R., Ansari, G.A. J. Am. Coll. Cardiol. (1991) [Pubmed]
  22. Genetic susceptibility to experimental cerebral aneurysm formation in the rat. Coutard, M., Osborne-Pellegrin, M. Stroke (1997) [Pubmed]
  23. Rupture of the internal elastic lamina and vascular fragility in stroke-prone spontaneously hypertensive rats. Coutard, M., Osborne-Pellegrin, M. Stroke (1991) [Pubmed]
  24. Collagen telopeptides (cross-linking sites) play a role in collagen gel lattice contraction. Woodley, D.T., Yamauchi, M., Wynn, K.C., Mechanic, G., Briggaman, R.A. J. Invest. Dermatol. (1991) [Pubmed]
  25. D-penicillamine and beta-aminopropionitrile effects on experimental filtering surgery. McGuigan, L.J., Mason, R.P., Sanchez, R., Quigley, H.A. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
  26. The effect of collagen cross-linkage inhibitors on rabbit corneas after radial keratotomy. Busin, M., Yau, C.W., Yamaguchi, T., McDonald, M.B., Kaufman, H.E. Invest. Ophthalmol. Vis. Sci. (1986) [Pubmed]
  27. The inhibition of lysyl oxidase in vivo by isoniazid and its reversal by pyridoxal. Effect on collagen cross-linking in the chick embryo. Carrington, M.J., Bird, T.A., Levene, C.I. Biochem. J. (1984) [Pubmed]
  28. Mechanism of insulin incorporation into alpha 2-macroglobulin: implications for the study of peptide and growth factor binding. Chu, C.T., Rubenstein, D.S., Enghild, J.J., Pizzo, S.V. Biochemistry (1991) [Pubmed]
  29. A molecular role for lysyl oxidase in breast cancer invasion. Kirschmann, D.A., Seftor, E.A., Fong, S.F., Nieva, D.R., Sullivan, C.M., Edwards, E.M., Sommer, P., Csiszar, K., Hendrix, M.J. Cancer Res. (2002) [Pubmed]
  30. Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2. Vadasz, Z., Kessler, O., Akiri, G., Gengrinovitch, S., Kagan, H.M., Baruch, Y., Izhak, O.B., Neufeld, G. J. Hepatol. (2005) [Pubmed]
  31. Examination of the stress-induced expression of the collagen binding heat shock protein, hsp47, in Xenopus laevis cultured cells and embryos. Hamilton, A.M., Heikkila, J.J. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2006) [Pubmed]
  32. Purification of enzymatically active human lysyl oxidase and lysyl oxidase-like protein from Escherichia coli inclusion bodies. Jung, S.T., Kim, M.S., Seo, J.Y., Kim, H.C., Kim, Y. Protein Expr. Purif. (2003) [Pubmed]
  33. Elastic fiber production in cardiovascular tissue-equivalents. Long, J.L., Tranquillo, R.T. Matrix Biol. (2003) [Pubmed]
  34. Characterization of an associated microfibril protein through recombinant DNA techniques. Horrigan, S.K., Rich, C.B., Streeten, B.W., Li, Z.Y., Foster, J.A. J. Biol. Chem. (1992) [Pubmed]
  35. Collagen deposition and the reversal of coronary reserve in cardiac hypertrophy. Isoyama, S., Ito, N., Satoh, K., Takishima, T. Hypertension (1992) [Pubmed]
  36. Urinary excretion of beta-aminopropionitrile and cyanoacetic acid. Fleisher, J.H., Peacock, E.E., Chvapil, M. Clin. Pharmacol. Ther. (1978) [Pubmed]
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