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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Counterpulsation


High impact information on Counterpulsation

  • We investigated the combined effectiveness of intra-aortic balloon counterpulsation and hyperosmotic mannitol (25%) on regional myocardial blood flow during acute coronary insufficiency [6].
  • RESULTS: Enhanced external counterpulsation led to symptomatic improvement (>/=1 Canadian Cardiovascular Society class) in 17 (74%) patients; EECP was associated with a significant immediate increase in average RH-PAT index after each treatment (p < 0.05) [7].
  • The current practice of intra-aortic balloon counterpulsation: results from the Benchmark Registry [8].
  • Female gender, greater age, postprocedural heparin and intraaortic balloon counterpulsation were predictive of higher risk [9].
  • Results of a randomized prospective trial of intraaortic balloon counterpulsation and intravenous nitroglycerin in patients with acute myocardial infarction [10].

Chemical compound and disease context of Counterpulsation

  • Effect of hypertonic mannitol and intraaortic counterpulsation on regional myocardial blood flow and ventricular performance in dogs during myocardial ischemia [11].
  • Several cardiac complications, such as pulmonary edema, temporary pacing, and need for intraaortic balloon pump counterpulsation, were observed more frequently in amiodarone-treated patients than in control patients [12].
  • Development of the postoperative hyperbilirubinemia was associated with a higher mortality (5.6% versus 0.5%, p < 0.01) and higher frequency of use of intraaortic balloon counterpulsation, especially for patients in whom the highest postoperative total bilirubin occurred after the first 2 days [13].
  • SUMMARY: Prompt triage of all patients in cardiogenic shock for early angiography, intra-aortic balloon pump counterpulsation, and early revascularization with PCI or bypass surgery is now the preferred management strategy [14].
  • To find the best predictors of outcome for patients undergoing intra-aortic balloon counterpulsation (IABP) for cardiogenic shock, we prospectively studied 30 consecutive patients by examining hemodynamic parameters and cardiac lactic acid extraction ratios before the procedure [15].

Biological context of Counterpulsation

  • To our knowledge, this is the first reported case of right ventricular infarct complicated by shock in which the simultaneous use of counterpulsation and dobutamine therapy resulted in a substantial increase in cardiac output [4].
  • OBJECTIVES: Enhanced external counterpulsation (EECP) rhythmically augments blood pressure (BP) by diastolic lower-body compression [16].
  • Hematological parameters including platelet count, D-dimer, Plasminogen activator inhibitor-1 (PAI-1) and fibrinogen degradation products (FDP) were checked respectively at the point of baseline, 24 hours, 48 hours and 24 hours post IABP counterpulsation [17].

Anatomical context of Counterpulsation


Associations of Counterpulsation with chemical compounds


Gene context of Counterpulsation

  • C1-INH therapy resulted in rapid hemodynamic stabilization of all patients; weaning from aortic counterpulsation and epinephrine support was possible within 1 day [23].
  • EECP-enhanced external counterpulsation [24].
  • Ten underwent operation, with counterpulsation support, within 3 weeks of development of the VSD [25].
  • Intra-aortic balloon counterpulsation (IABP) both increases mean arterial pressure and cerebral blood flow and therefore possibly reduces complications due to hemodynamic instability during and after CAS [26].
  • A patient with ischemic cardiomyopathy requiring intra-aortic balloon counterpulsation (IABC) had to withstand a temporary cessation of IABC (period I), during which she had marked central venous pulsations and a pulse oximeter bias of -18% [27].

Analytical, diagnostic and therapeutic context of Counterpulsation


  1. Effect of intra-aortic balloon counterpulsation on the motion and perfusion of acutely ischemic myocardium. An experimental echocardiographic study. Kerber, R.E., Marcus, M.L., Ehrhardt, J., Abboud, F.M. Circulation (1976) [Pubmed]
  2. External counterpulsation therapy improves endothelial function in patients with refractory angina pectoris. Shechter, M., Matetzky, S., Feinberg, M.S., Chouraqui, P., Rotstein, Z., Hod, H. J. Am. Coll. Cardiol. (2003) [Pubmed]
  3. Afterload reduction and cardiac performance. Physiologic basis of systemic vasodilators as a new approach in treatment of congestive heart failure. Mason, D.T. Am. J. Med. (1978) [Pubmed]
  4. Counterpulsation and dobutamine. Their use in treatment of cardiogenic shock due to right ventricular infarct. Iqbal, M.Z., Liebson, P.R. Arch. Intern. Med. (1981) [Pubmed]
  5. The multicenter study of enhanced external counterpulsation (MUST-EECP): effect of EECP on exercise-induced myocardial ischemia and anginal episodes. Arora, R.R., Chou, T.M., Jain, D., Fleishman, B., Crawford, L., McKiernan, T., Nesto, R.W. J. Am. Coll. Cardiol. (1999) [Pubmed]
  6. The influence of combined intra-aortic balloon counterpulsation and hyperosomotic mannitol on regional myocardial blood flow in ischemic myocardium in the dog. Watson, J.T., Fixler, D.E., Platt, M.R., Nall, B.B., Jett, G.K., Willerson, J.T. Circ. Res. (1976) [Pubmed]
  7. Enhanced external counterpulsation improves endothelial function in patients with symptomatic coronary artery disease. Bonetti, P.O., Barsness, G.W., Keelan, P.C., Schnell, T.I., Pumper, G.M., Kuvin, J.T., Schnall, R.P., Holmes, D.R., Higano, S.T., Lerman, A. J. Am. Coll. Cardiol. (2003) [Pubmed]
  8. The current practice of intra-aortic balloon counterpulsation: results from the Benchmark Registry. Ferguson, J.J., Cohen, M., Freedman, R.J., Stone, G.W., Miller, M.F., Joseph, D.L., Ohman, E.M. J. Am. Coll. Cardiol. (2001) [Pubmed]
  9. Peripheral vascular complications in the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT-I). Omoigui, N.A., Califf, R.M., Pieper, K., Keeler, G., O'Hanesian, M.A., Berdan, L.G., Mark, D.B., Talley, J.D., Topol, E.J. J. Am. Coll. Cardiol. (1995) [Pubmed]
  10. Results of a randomized prospective trial of intraaortic balloon counterpulsation and intravenous nitroglycerin in patients with acute myocardial infarction. Flaherty, J.T., Becker, L.C., Weiss, J.L., Brinker, J.A., Bulkley, B.H., Gerstenblith, G., Kallman, C.H., Weisfeldt, M.L. J. Am. Coll. Cardiol. (1985) [Pubmed]
  11. Effect of hypertonic mannitol and intraaortic counterpulsation on regional myocardial blood flow and ventricular performance in dogs during myocardial ischemia. Willerson, J.T., Watson, J.T., Platt, M.R. Am. J. Cardiol. (1976) [Pubmed]
  12. Low-dose amiodarone-related complications after cardiac operations. Dimopoulou, I., Marathias, K., Daganou, M., Prapas, S., Stavridis, G., Khoury, M., Geroulanos, S., Cokkinos, D.V. J. Thorac. Cardiovasc. Surg. (1997) [Pubmed]
  13. Hyperbilirubinemia after cardiac operation. Incidence, risk factors, and clinical significance. Wang, M.J., Chao, A., Huang, C.H., Tsai, C.H., Lin, F.Y., Wang, S.S., Liu, C.C., Chu, S.H. J. Thorac. Cardiovasc. Surg. (1994) [Pubmed]
  14. Management strategies for cardiogenic shock. Sanborn, T.A., Feldman, T. Curr. Opin. Cardiol. (2004) [Pubmed]
  15. Anaerobic metabolism in patients undergoing intra-aortic balloon counterpulsation for cardiogenic shock. Wang, T.L., Hsu, K.L., Chiang, F.T., Tseng, C.D., Tseng, Y.Z. J. Formos. Med. Assoc. (1995) [Pubmed]
  16. Enhanced external counterpulsation does not compromise cerebral autoregulation. Marthol, H., Werner, D., Brown, C.M., Hecht, M., Daniel, W.G., Hilz, M.J. Acta neurologica Scandinavica. (2005) [Pubmed]
  17. Anticoagulation therapy in intra-aortic balloon counterpulsation: does IABP really need anti-coagulation? Jiang, C.Y., Zhao, L.L., Wang, J.A., Mohammod, B. J. Zhejiang Univ. Sci. (2003) [Pubmed]
  18. Angina patients with diastolic versus systolic heart failure demonstrate comparable immediate and one-year benefit from enhanced external counterpulsation. Lawson, W.E., Silver, M.A., Hui, J.C., Kennard, E.D., Kelsey, S.F. J. Card. Fail. (2005) [Pubmed]
  19. Perioperative right heart failure: treatment. Gaines, W.E. Cardiovascular clinics. (1987) [Pubmed]
  20. Efficacy of nitroprusside therapy in postcardiotomy low-output syndrome necessitating intra-aortic balloon counterpulsation. Sturm, J.T., Fuhrman, T.M., Igo, S.R., Norman, J.C. J. Thorac. Cardiovasc. Surg. (1979) [Pubmed]
  21. The temporal relationship in arterial and venous prostacyclin and thromboxane activity during 24 hours of intraaortic balloon counterpulsation in dogs. Hoover, E.L., Kharma, B., Ross, M., Webb, H., Hsu, H.K., Clark, L., Toporoff, B., Cunningham, J.N. Ann. Thorac. Surg. (1988) [Pubmed]
  22. Systematic off-pump coronary artery revascularization in multivessel disease: experience of three hundred cases. Cartier, R., Brann, S., Dagenais, F., Martineau, R., Couturier, A. J. Thorac. Cardiovasc. Surg. (2000) [Pubmed]
  23. Rescue therapy with C1-esterase inhibitor concentrate after emergency coronary surgery for failed PTCA. Bauernschmitt, R., Böhrer, H., Hagl, S. Intensive care medicine. (1998) [Pubmed]
  24. EECP-enhanced external counterpulsation. Conti, C.R. J. Am. Coll. Cardiol. (1999) [Pubmed]
  25. Repair of postinfarction ventricular septal defect in the elderly. Early and long-term results. Weintraub, R.M., Thurer, R.L., Wei, J., Aroesty, J.M. J. Thorac. Cardiovasc. Surg. (1983) [Pubmed]
  26. Intra-aortic counterpulsation during carotid stenting. Hennen, B., Gröschel-Guth, A., Scheller, B., Hammer, B., Böhm, M. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. (2001) [Pubmed]
  27. Central venous pulsations associated with a falsely low oxygen saturation measured by pulse oximetry. Sami, H.M., Kleinman, B.S., Lonchyna, V.A. Journal of clinical monitoring. (1991) [Pubmed]
  28. Percutaneous transluminal coronary angioplasty for rest angina pectoris requiring intravenous nitroglycerin and intraaortic balloon counterpulsation. Morrison, D.A. Am. J. Cardiol. (1990) [Pubmed]
  29. Residual effects when chronic propranolol therapy is discontinued within 48 hours of cardiopulmonary bypass. Frank, G., Tyers, O., Hughes, H.C. Am. Heart J. (1976) [Pubmed]
  30. Treatment of post resuscitation myocardial dysfunction: aortic counterpulsation versus dobutamine. Tennyson, H., Kern, K.B., Hilwig, R.W., Berg, R.A., Ewy, G.A. Resuscitation. (2002) [Pubmed]
  31. A review of enhanced external counterpulsation clinical trials. Beller, G.A. Clinical cardiology. (2002) [Pubmed]
  32. Isosorbide dinitrate alone and in association with intra-aortic balloon counterpulsation in acute myocardial infarction. A clinical study by precordial ECG mapping. Vassanelli, C., Menegatti, G., Nidasio, G.P., Righetti, B., Olivieri, D., Poppi, A. Giornale italiano di cardiologia. (1982) [Pubmed]
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