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Disease relevance of Siderosis


High impact information on Siderosis

  • Constant subcutaneous deferoxamine administration may prove to be an effective and practical means of eliminating large quantities of iron in siderosis [6].
  • 4-Dimethylaminoazobenzene was fed to Wistar-derived, male, albino rats after hepatic siderosis had been induced by including ferric citrate in the diet [7].
  • These findings indicate that in some cases of neonatal hemochromatosis, extrahepatic siderosis may be caused by hepatic injury rather than primarily due to excessive transport of iron from mother to fetus and support speculation that in some instances an infective agent may be responsible [2].
  • Subnormal activity of hepatic uroporphyrinogen decarboxylase is responsible for the derangement of porphyrin biosynthesis in both sporadic and familial porphyria cutanea tarda, but the enzymatic defect is not clinically expressed in the absence of hepatic siderosis [1].
  • Heterozygosity for HLA-linked hemochromatosis as a likely cause of the hepatic siderosis associated with sporadic porphyria cutanea tarda [1].

Chemical compound and disease context of Siderosis


Biological context of Siderosis


Anatomical context of Siderosis


Gene context of Siderosis


Analytical, diagnostic and therapeutic context of Siderosis


  1. Heterozygosity for HLA-linked hemochromatosis as a likely cause of the hepatic siderosis associated with sporadic porphyria cutanea tarda. Kushner, J.P., Edwards, C.Q., Dadone, M.M., Skolnick, M.H. Gastroenterology (1985) [Pubmed]
  2. Fetal liver disease may precede extrahepatic siderosis in neonatal hemochromatosis. Hoogstraten, J., de Sa, D.J., Knisely, A.S. Gastroenterology (1990) [Pubmed]
  3. Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis. Pennell, D.J., Berdoukas, V., Karagiorga, M., Ladis, V., Piga, A., Aessopos, A., Gotsis, E.D., Tanner, M.A., Smith, G.C., Westwood, M.A., Wonke, B., Galanello, R. Blood (2006) [Pubmed]
  4. Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis. Bassett, M.L., Halliday, J.W., Powell, L.W. Hepatology (1986) [Pubmed]
  5. Transthyretin amyloidosis and superficial siderosis of the CNS. Mascalchi, M., Salvi, F., Pirini, M.G., D'Errico, A., Ferlini, A., Lolli, F., Plasmati, R., Tessa, C., Villari, N., Tassinari, C.A. Neurology (1999) [Pubmed]
  6. Continuous subcutaenous administration of deferoxamine in patients with iron overload. Propper, R.D., Cooper, B., Rufo, R.R., Nienhuis, A.W., Anderson, W.F., Bunn, H.F., Rosenthal, A., Nathan, D.G. N. Engl. J. Med. (1977) [Pubmed]
  7. Hyperplastic foci in precancerous rat liver: light microscopic and electron microscopic study. Timme, A.H. J. Natl. Cancer Inst. (1978) [Pubmed]
  8. Ultrastructural abnormalities in carcinogen-induced hepatocellular altered foci identified by resistance to iron accumulation. Hirota, N., Williams, G.M. Cancer Res. (1982) [Pubmed]
  9. Ethane exhalation and vitamin E/ubiquinol status as markers of lipid peroxidation in ferrocene iron-loaded rats. Dresow, B., Albert, C., Zimmermann, I., Nielsen, P. Hepatology (1995) [Pubmed]
  10. Uroporphyria in the uroporphyrinogen decarboxylase-deficient mouse: Interplay with siderosis and polychlorinated biphenyl exposure. Franklin, M.R., Phillips, J.D., Kushner, J.P. Hepatology (2002) [Pubmed]
  11. Angiosarcoma with pulmonary siderosis and persistent reticulocytosis. Steroid responsiveness suggests an immune basis. Rajdev, N., Green, R., Crosby, W.H. Arch. Intern. Med. (1978) [Pubmed]
  12. A mouse model of familial porphyria cutanea tarda. Phillips, J.D., Jackson, L.K., Bunting, M., Franklin, M.R., Thomas, K.R., Levy, J.E., Andrews, N.C., Kushner, J.P. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  13. Tumor necrosis factor alpha promoter polymorphisms influence the phenotypic expression of hereditary hemochromatosis. Fargion, S., Valenti, L., Dongiovanni, P., Scaccabarozzi, A., Fracanzani, A.L., Taioli, E., Mattioli, M., Sampietro, M., Fiorelli, G. Blood (2001) [Pubmed]
  14. Successful interferon therapy reverses enhanced hepatic iron accumulation and lipid peroxidation in chronic hepatitis C. Kageyama, F., Kobayashi, Y., Kawasaki, T., Toyokuni, S., Uchida, K., Nakamura, H. Am. J. Gastroenterol. (2000) [Pubmed]
  15. Tired blood and rusty livers. Saltman, P., Hegenauer, J., Christopher, J. Ann. Clin. Lab. Sci. (1976) [Pubmed]
  16. Testing for haemochromatosis in a liver clinic population: relationship between ethnic origin, HFE gene mutations, liver histology and serum iron markers. Moodie, S.J., Ang, L., Stenner, J.M., Finlayson, C., Khotari, A., Levin, G.E., Maxwell, J.D. European journal of gastroenterology & hepatology. (2002) [Pubmed]
  17. Central nervous system superficial siderosis, headache, and epilepsy. Iannaccone, S., Golzi, V., Sferrazza, B., de Rino, F., Smirne, S., Ferini-Strambi, L. Headache. (1999) [Pubmed]
  18. Transferrin glycans: a possible link between alcoholism and hepatic siderosis. Regoeczi, E., Chindemi, P.A., Debanne, M.T. Alcohol. Clin. Exp. Res. (1984) [Pubmed]
  19. The effect of ethanol on the uptake, binding, and desialylation of transferrin by rat liver endothelium: implications in the pathogenesis of alcohol-associated hepatic siderosis. Mihas, A.A., Tavassoli, M. Am. J. Med. Sci. (1991) [Pubmed]
  20. Effects of AZT on cellular iron homeostasis. Bozzi, A., Brisdelli, F., D'Alessandro, A.M., D'Andrea, G., Lizzi, A.R., Rinaldi, A.C., Oratore, A. Biometals (2004) [Pubmed]
  21. Lymph node siderosis in trypan blue treated rats. Dumont, A.E. Lymphology. (1988) [Pubmed]
  22. Increased duodenal expression of divalent metal transporter 1 and iron-regulated gene 1 in cirrhosis. Stuart, K.A., Anderson, G.J., Frazer, D.M., Murphy, T.L., Powell, L.W., Fletcher, L.M., Crawford, D.H. Hepatology (2004) [Pubmed]
  23. Hepatic iron overload: direct HFE (HLA-H) mutation analysis vs quantitative iron assays for the diagnosis of hereditary hemochromatosis. Press, R.D., Flora, K., Gross, C., Rabkin, J.M., Corless, C.L. Am. J. Clin. Pathol. (1998) [Pubmed]
  24. Hemochromatosis (HFE) and transferrin receptor-1 (TFRC1) genes in sporadic porphyria cutanea tarda (sPCT). Lamoril, J., Andant, C., Gouya, L., Malonova, E., Grandchamp, B., Martásek, P., Deybac, J.C., Puy, H. Cell. Mol. Biol. (Noisy-le-grand) (2002) [Pubmed]
  25. Regulation of hepatic transferrin, transferrin receptor and ferritin genes in human siderosis. Pietrangelo, A., Rocchi, E., Ferrari, A., Ventura, E., Cairo, G. Hepatology (1991) [Pubmed]
  26. Rapid development of hepatocellular siderosis after liver transplantation for neonatal hemochromatosis. Egawa, H., Berquist, W., Garcia-Kennedy, R., Cox, K., Knisely, A.S., Esquivel, C.O. Transplantation (1996) [Pubmed]
  27. Prevention of heart disease by subcutaneous desferrioxamine in patients with thalassaemia major. Richardson, M.E., Matthews, R.N., Alison, J.F., Menahem, S., Mitvalsky, J., Byrt, E., Harper, R.W. Australian and New Zealand journal of medicine. (1993) [Pubmed]
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