Disease relevance of Absorbable Implants

• Their effectiveness without significant toxicity, together with new biodegradable implants for their easily acceptable long-term administration, suggest that a highly selective medical means of fully inhibiting ovarian estrogen production is now available for more extensive trials in breast cancer patients [1].

High impact information on Absorbable Implants

• They were randomized to receive the biodegradable implant either without cisplatin (control group) or with cisplatin (OPLA-Pt group) and were targeted to receive four doses of an adjuvant cisplatin chemotherapy protocol [2].
• BACKGROUND: Progress has been made in the design of bioabsorbable implants, with reduced complication rates and slower degradation times [3].
• CONCLUSIONS: Amifostine in biodegradable implant was effective [4].
• PURPOSE: To fabricate and characterize in vitro and in vivo performance of a sustained release biodegradable implant for N-4-(benzoylaminophenylsulfonyl glycine) (BAPSG), a novel aldose reductase inhibitor [5].
• The degradation, swelling and erosion properties of biodegradable implants prepared by extrusion or compression moulding of poly(lactide-co-glycolide) and ABA triblock copolymers [6].

Biological context of Absorbable Implants

• Biodegradable implants made from polyglycolic and polylactic acid co-polymers undergo degradation by hydrolysis which results in loss of their mechanical strength [7].

Anatomical context of Absorbable Implants

• An ECM analogue which has been shown to be capable of inducing regeneration of functional sciatic nerve in the rat over a gap larger than 10 mm was incorporated in the design of a biodegradable implant for peripheral nerve regeneration [8].
• Use of a bioabsorbable implant for the repair of severed digital flexor tendons in four horses [9].
• The effect of a penetrating biodegradable implant on the epiphyseal plate: an experimental study on growing rabbits with special regard to polyglactin 910 [10].
• This study evaluated the ability of biodegradable implants fabricated from polymers and co-polymers of polylactic acid (PLA) and polyglycolic acid (PGA) to induce regeneration of surgically created defects in the dog esophagus [11].

Associations of Absorbable Implants with chemical compounds

• Biodegradable implants made of alpha-hydroxypolyesters, such as polylactic acid, polyglycolic acid, or their copolymers, undergo bulk degradation with a concomitant mass loss [12].
• Polycaprolactone/glass bioabsorbable implant in a rabbit humerus fracture model [13].
• In conclusion, the release of a gonadotropin-releasing hormone agonist by a biodegradable implant achieved better efficacy in reducing endometriotic lesions than the IN mode of administration [14].
• The cylindrical biodegradable implants were made of polylactide-glycolide copolymer (polyglactin 910) [15].
• Biodegradable implants from poly-(alpha-hydroxy acid) polymers for isoniazid delivery [16].

Gene context of Absorbable Implants

• CLINICAL RELEVANCE: The biodegradable implant containing BMP that was used in the present study to treat diaphyseal nonunion is an effective bone-graft substitute [17].
• Stability studies of a somatostatin analogue in biodegradable implants [18].
• Four women in each group were taking either a low dosage progestogen compound like norethisterone (NET) 350 micrograms or d-norgestrel (d-Ng) 50 micrograms alone or low dosage combination pills containing NET 1 mg or d-Ng 150 micrograms with 30 micrograms ethinyl estradiol (EE2) or a biodegradable implant containing 25 mg NET or d-Ng [19].
• When all costs also for the implant removal procedure after metallic fixation were included, the average cost saved per patient by using absorbable implants in a trimalleolar fracture was FIM 2023 (4.4% of the total costs) [20].
• Early findings in a pilot study of anterior cervical interbody fusion in which recombinant human bone morphogenetic protein-2 was used with poly(L-lactide-co-D,L-lactide) bioabsorbable implants [21].

Analytical, diagnostic and therapeutic context of Absorbable Implants

• We reviewed 12 male patients with scaphoid nonunions treated by open reduction, bone grafting, and internal fixation with biodegradable implants made of self-reinforced poly- l-lactic acid [22].

References