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Chemical Compound Review

Biosone     10-hydroxy- 2,4a,6a,6b,9,9,12a- heptamethyl...

Synonyms: Glycyrrhetin, SureCN25465, AGN-PC-00FFIB, NSC-35350, AC1L1FGT, ...
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Disease relevance of GLYCYRRHETINIC ACID


High impact information on GLYCYRRHETINIC ACID


Chemical compound and disease context of GLYCYRRHETINIC ACID


Biological context of GLYCYRRHETINIC ACID


Anatomical context of GLYCYRRHETINIC ACID


Associations of GLYCYRRHETINIC ACID with other chemical compounds



  • 18alpha,beta-Glycyrrhetic acid (GA) did not inhibit IL-8 but inhibited eotaxin 1 [22].
  • Inhibitory effects of glycyrrhetic acid and its related compounds on 3 alpha-hydroxysteroid dehydrogenase of rat liver cytosol [23].
  • Interestingly, compounds 14, 15, and 17 showed similar inhibitory effects (89-92%, 66-69%, and 24-29% at 1000, 500, and 100 mol ratio to TPA, respectively) against EBV-EA with potencies comparable to those of glycyrrhetic acid, a known natural antitumor-promoter [24].
  • Glycyrrhizin (G) and glycyrrhetic acid (GA) were separated by using nano-liquid chromatography (nano-LC) in a fused silica capillary packed with RP18 stationary phase (75 microm ID, effective length 33 cm, packed 23 cm) eluting at 300 nL/min in a gradient mode [25].

Analytical, diagnostic and therapeutic context of GLYCYRRHETINIC ACID


  1. A population physiologically based pharmacokinetic/pharmacodynamic model for the inhibition of 11-beta-hydroxysteroid dehydrogenase activity by glycyrrhetic acid. Ploeger, B., Mensinga, T., Sips, A., Deerenberg, C., Meulenbelt, J., DeJongh, J. Toxicol. Appl. Pharmacol. (2001) [Pubmed]
  2. Purification and characterization of glycyrrhetic acid mono-glucuronide beta-D-glucuronidase in Eubacterium sp. GLH. Akao, T. Biol. Pharm. Bull. (1999) [Pubmed]
  3. Competition in the metabolism of glycyrrhizin with glycyrrhetic acid mono-glucuronide by mixed Eubacterium sp. GLH and Ruminococcus sp. PO1-3. Akao, T. Biol. Pharm. Bull. (2000) [Pubmed]
  4. Preparation of neocarzinostatin apoprotein mutants and the randomized library on the chromophore-binding cavity. Tomioka, Y., Kisara, S., Yoshizawa, S., Ozawa, M., Suzuki, N., Yamaguchi, H., Hishinuma, T., Mizugaki, M., Goto, J. Biol. Pharm. Bull. (2006) [Pubmed]
  5. Hasty effect on the metabolism of glycyrrhizin by Eubacterium sp. GLH with Ruminococcus sp. PO1-3 and Clostridium innocuum ES24-06 of human intestinal bacteria. Akao, T. Biol. Pharm. Bull. (2000) [Pubmed]
  6. Acute intrarenal administration of cortisol has no effect on renal blood flow in hypertensive individuals. van Uum, S.H., Houben, A.J., Hermus, A.R., Kroon, A.A., Walker, B.R., Sweep, C.G., Smits, P., de Leeuw, P.W., Lenders, J.W. J. Hypertens. (2002) [Pubmed]
  7. Enzyme-linked immunosorbent assay for glycyrrhizin using anti-glycyrrhizin monoclonal antibody and an eastern blotting technique for glucuronides of glycyrrhetic acid. Shan, S., Tanaka, H., Shoyama, Y. Anal. Chem. (2001) [Pubmed]
  8. Antitumor-promoting activity of glycyrrhetic acid in mouse skin tumor formation induced by 7,12-dimethylbenz[a]anthracene plus teleocidin. Nishino, H., Kitagawa, K., Iwashima, A. Carcinogenesis (1984) [Pubmed]
  9. The pharmacokinetics of glycyrrhizic acid evaluated by physiologically based pharmacokinetic modeling. Ploeger, B., Mensinga, T., Sips, A., Seinen, W., Meulenbelt, J., DeJongh, J. Drug Metab. Rev. (2001) [Pubmed]
  10. Metabolism of glycyrrhetic acid by rat liver microsomes: glycyrrhetinate dehydrogenase. Akao, T., Akao, T., Kobashi, K. Biochim. Biophys. Acta (1990) [Pubmed]
  11. Interaction of licorice on glycyrrhizin pharmacokinetics. Cantelli-Forti, G., Maffei, F., Hrelia, P., Bugamelli, F., Bernardi, M., D'Intino, P., Maranesi, M., Raggi, M.A. Environ. Health Perspect. (1994) [Pubmed]
  12. Hydrolysis of glycyrrhizin to 18 beta-glycyrrhetyl monoglucuronide by lysosomal beta-D-glucuronidase of animal livers. Akao, T., Akao, T., Hattori, M., Kanaoka, M., Yamamoto, K., Namba, T., Kobashi, K. Biochem. Pharmacol. (1991) [Pubmed]
  13. Inhibition of the specific binding of 12-O-tetradecanoylphorbol-13-acetate to mouse epidermal membrane fractions by glycyrrhetic acid. Kitagawa, K., Nishino, H., Iwashima, A. Oncology (1986) [Pubmed]
  14. Kinetic analysis of glycyrrhetic acid, an active metabolite of glycyrrhizin, in rats: role of enterohepatic circulation. Kawakami, J., Yamamura, Y., Santa, T., Kotaki, H., Uchino, K., Sawada, Y., Iga, T. Journal of pharmaceutical sciences. (1993) [Pubmed]
  15. Glycyrrhetic acid inhibits tumor-promoting activity of teleocidin and 12-O-tetradecanoylphorbol-13-acetate in two-stage mouse skin carcinogenesis. Nishino, H., Yoshioka, K., Iwashima, A., Takizawa, H., Konishi, S., Okamoto, H., Okabe, H., Shibata, S., Fujiki, H., Sugimura, T. Jpn. J. Cancer Res. (1986) [Pubmed]
  16. Profound difference of metabolic pharmacokinetics between pure glycyrrhizin and glycyrrhizin in licorice decoction. Hou, Y.C., Hsiu, S.L., Ching, H., Lin, Y.T., Tsai, S.Y., Wen, K.C., Chao, P.D. Life Sci. (2005) [Pubmed]
  17. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-stimulated 3-O-methyl-glucose transport in mouse Swiss 3T3 fibroblasts by glycyrrhetic acid. Kitagawa, K., Nishino, H., Iwashima, A. Cancer Lett. (1984) [Pubmed]
  18. Inhibition of P-glycoprotein-mediated transport by terpenoids contained in herbal medicines and natural products. Yoshida, N., Koizumi, M., Adachi, I., Kawakami, J. Food Chem. Toxicol. (2006) [Pubmed]
  19. Glycyrrhizic acid in liquorice--evaluation of health hazard. Størmer, F.C., Reistad, R., Alexander, J. Food Chem. Toxicol. (1993) [Pubmed]
  20. Direct determination of serum glycyrrhetic acid by a monoclonal antibody-based inhibition ELISA using ibuprofen for releasing serum albumin-bound glycyrrhetic acid. Itoh, K., Hayasaka, M., Niizeki, M., Nozaki, S., Ishiwata, S., Tomioka, Y., Mizugaki, M. Journal of immunoassay. (1996) [Pubmed]
  21. The influence of commonly prescribed synthetic drugs for peptic ulcer on the pharmacokinetic fate of glycyrrhizin from Shaoyao-Gancao-tang. He, J.X., Akao, T., Nishino, T., Tani, T. Biol. Pharm. Bull. (2001) [Pubmed]
  22. Glycyrrhizin and related compounds down-regulate production of inflammatory chemokines IL-8 and eotaxin 1 in a human lung fibroblast cell line. Matsui, S., Matsumoto, H., Sonoda, Y., Ando, K., Aizu-Yokota, E., Sato, T., Kasahara, T. Int. Immunopharmacol. (2004) [Pubmed]
  23. Inhibitory effects of glycyrrhetic acid and its related compounds on 3 alpha-hydroxysteroid dehydrogenase of rat liver cytosol. Akao, T., Akao, T., Hattori, M., Namba, T., Kobashi, K. Chem. Pharm. Bull. (1992) [Pubmed]
  24. Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters. Nakamura, S., Kozuka, M., Bastow, K.F., Tokuda, H., Nishino, H., Suzuki, M., Tatsuzaki, J., Morris Natschke, S.L., Kuo, S.C., Lee, K.H. Bioorg. Med. Chem. (2005) [Pubmed]
  25. Use of nano-liquid chromatography for the analysis of glycyrrhizin and glycyrrhetic acid in licorice roots and candies. Fanali, S., Aturkil, Z., D'Orazio, G., Raggi, M.A., Quaglia, M.G., Sabbioni, C., Rocco, A. Journal of separation science. (2005) [Pubmed]
  26. Determination of glycyrrhetic acid in human serum by high-performance liquid chromatography with ultraviolet detection. Takeda, S., Ono, H., Wakui, Y., Asami, A., Matsuzaki, Y., Sasaki, H., Aburada, M., Hosoya, E. J. Chromatogr. (1990) [Pubmed]
  27. Improvement of selectivity and sensitivity by column switching in the determination of glycyrrhizin and glycyrrhetic acid in human plasma by high-performance liquid chromatography. de Groot, G., Koops, R., Hogendoorn, E.A., Goewie, C.E., Savelkoul, T.J., van Vloten, P. J. Chromatogr. (1988) [Pubmed]
  28. Bioavailability of glycyrrhizin from Shaoyao-Gancao-Tang in laxative-treated rats. Goto, E., He, J.X., Akao, T., Tani, T. J. Pharm. Pharmacol. (2005) [Pubmed]
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