Disease relevance of Indigofera

• Enzymes catalyzing steps from ethanol to acetyl-coenzyme A, from malate to pyruvate, and from pyruvate to glucose 6-phosphate were identified in ethanol-grown Pseudomonas indigofera [1].
• Indirubin from Indigofera tinctoria is useful for the treatment of chronic myelocytic leukemia [2].
• Acute and subchronic evaluation of Indigofera arrecta: absence of both toxicity and modulation of selected cytochrome P450 isozymes in ddY mice [3].

High impact information on Indigofera

• 3-Nitropropionate, the toxic substance of Indigofera, is a suicide inactivator of succinate dehydrogenase [4].
• The non-protein amino acid indospicine, which occurs in the free state in high concentration in the tropical pasture legume Indigofera spicata, causes toxic liver lesions in ruminants [5].
• Effects on the liver in the rat of ingestion of Indigofera spicata, a legume containing an inhibitor of arginine metabolism [5].
• Growth at 0.033 h(-1) enhanced survival of V. indigofera biofilms against betadine [6].
• The thermophilic Bacillus malate synthase is considerably more thermostable than its mesophilic counterparts from E. coli, Bacillus licheniformis, and Pseudomonas indigofera [7].

Chemical compound and disease context of Indigofera

• Isocitrate lyase from Pseudomonas indigofera: pH dependence of catalysis and binding of substrates and inhibitors [8].
• In Pseudomonas indigofera, the catabolism of agmatine can also occur via an initial hydrolysis of the amidino group to putrescine catalyzed by an agmatine amidinohydrolase [9].

Associations of Indigofera with chemical compounds

• Itaconate, a potent inhibitor of isocitrate lyase, abolished growth of P. indigofera on ethanol at concentrations that had little effect upon growth on glucose [1].
• Two flavonol triglycosides from flowers of Indigofera hebepetala [10].
• A lignan and two acylphloroglucinols have been isolated from the ethyl acetate soluble fraction of the whole plant of Indigofera hetrantha [11].
• Two unique glucose esters of 3-nitropropanoic acid with acryloyl moieties, kirilowin A and kirilowin B, were isolated from the roots of Indigofera kirilowii [12].
• The present study aimed at assessing the protective effect of Indigofera oblongifolia on carbon tetrachloride (CCl4-induced hepatotoxicity [13].

Gene context of Indigofera

• Indigofera arrecta, an anti diabetic plant was investigated in ddY mice to determine its acute and subchronic effects, and whether it modulated hepatic cytochrome P450 (CYP) isozymes and glutathione (GSH) [3].

Analytical, diagnostic and therapeutic context of Indigofera

• Chemoprevention of N-nitrosodiethylamine induced phenobarbitol promoted liver tumors in rat by extract of Indigofera aspalathoides [14].

References