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MeSH Review

Meningococcal Infections

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Disease relevance of Meningococcal Infections


High impact information on Meningococcal Infections

  • The meningococcal class 1 outer membrane protein (OMP) plays an important role in the development of protective immunity against meningococcal infection, and is therefore considered to be a promising candidate antigen (Ag) for a meningococcal vaccine [6].
  • Antibody against both the protein serotype antigen and the capsular polysaccharide were induced as a result of meningococcal infection [7].
  • Because we had no information on genotypes of patients who died, we also genotyped 183 first-degree relatives of a consecutive series of patients with meningococcal infection for the 4G/5G deletion/insertion polymorphism in the promoter region of the plasminogen-activator-inhibitor-1 gene (PAI-1) [8].
  • It is possible that C6-deficient patients have reduced mortality from meningococcal infection because their serum cannot cause acute release of endotoxin from the invading organism and extensive tissue damage is thus avoided [9].
  • Sensing via TLR4 probably contributes to the early containment of meningococcal infection, and sensing defects create increased risk of disease [10].

Chemical compound and disease context of Meningococcal Infections


Biological context of Meningococcal Infections


Anatomical context of Meningococcal Infections


Gene context of Meningococcal Infections


Analytical, diagnostic and therapeutic context of Meningococcal Infections


  1. Monoclonal antibodies to the rough lipopolysaccharide of Neisseria meningitidis protect infant rats from meningococcal infection. Saukkonen, K., Leinonen, M., Käyhty, H., Abdillahi, H., Poolman, J.T. J. Infect. Dis. (1988) [Pubmed]
  2. Bacterial meningitis. Rational selection and use of antibacterial drugs. Whitby, M., Finch, R. Drugs (1986) [Pubmed]
  3. T-cell responses to outer membrane proteins of Neisseria meningitidis: comparative study of the Opa, Opc, and PorA proteins. Wiertz, E.J., Delvig, A., Donders, E.M., Brugghe, H.F., van Unen, L.M., Timmermans, H.A., Achtman, M., Hoogerhout, P., Poolman, J.T. Infect. Immun. (1996) [Pubmed]
  4. Increased tissue thromboplastin activity in monocytes of patients with meningococcal infection: related to an unfavourable prognosis. Osterud, B., Flaegstad, T. Thromb. Haemost. (1983) [Pubmed]
  5. Intrafamilial meningococcal meningitis. Naveh, Y., Merzbach, D. Eur. J. Pediatr. (1980) [Pubmed]
  6. Identification of T cell epitopes occurring in a meningococcal class 1 outer membrane protein using overlapping peptides assembled with simultaneous multiple peptide synthesis. Wiertz, E.J., van Gaans-van den Brink, J.A., Gausepohl, H., Prochnicka-Chalufour, A., Hoogerhout, P., Poolman, J.T. J. Exp. Med. (1992) [Pubmed]
  7. Protection against group B meningococcal disease. II. Infection and resulting immunity in a guinea pig model. Frasch, C.E., Robbins, J.D. J. Exp. Med. (1978) [Pubmed]
  8. Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock. Westendorp, R.G., Hottenga, J.J., Slagboom, P.E. Lancet (1999) [Pubmed]
  9. Meningococcal septicaemia in a C6-deficient patient and effects of plasma transfusion on lipopolysaccharide release. Lehner, P.J., Davies, K.A., Walport, M.J., Cope, A.P., Würzner, R., Orren, A., Morgan, B.P., Cohen, J. Lancet (1992) [Pubmed]
  10. Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Smirnova, I., Mann, N., Dols, A., Derkx, H.H., Hibberd, M.L., Levin, M., Beutler, B. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  11. Minocycline for prophylaxis of infection with Neisseria meningitidis: high rate of side effects in recipients. Drew, T.M., Altman, R., Black, K., Goldfield, M. J. Infect. Dis. (1976) [Pubmed]
  12. Sequence of the structural gene (rmpM) for the class 4 outer membrane protein of Neisseria meningitidis, homology of the protein to gonococcal protein III and Escherichia coli OmpA, and construction of meningococcal strains that lack class 4 protein. Klugman, K.P., Gotschlich, E.C., Blake, M.S. Infect. Immun. (1989) [Pubmed]
  13. Activities of eight new beta-lactam antibiotics and seven antibiotic combinations against Neisseria meningitidis. Scribner, R.K., Wedro, B.C., Weber, A.H., Marks, M.I. Antimicrob. Agents Chemother. (1982) [Pubmed]
  14. Prevalence of maltose-negative Neisseria meningitidis variants during an epidemic period in Spain. Sáez-Nieto, J.A., Fenoll, A., Vazquez, J., Casal, J. J. Clin. Microbiol. (1982) [Pubmed]
  15. Plasma patterns of tumor necrosis factor-alpha (TNF) and TNF soluble receptors during acute meningococcal infections and the effect of plasma exchange. van Deuren, M., Frieling, J.T., van der Ven-Jongekrijg, J., Neeleman, C., Russel, F.G., van Lier, H.J., Bartelink, A.K., van der Meer, J.W. Clin. Infect. Dis. (1998) [Pubmed]
  16. Turnover in the transferrin iron pool during the hypoferremic phase of experimental Neisseria meningitidis infection in mice. Letendre, E.D., Holbein, B.E. Infect. Immun. (1983) [Pubmed]
  17. Antibody response to meningococcal polysaccharides A and C in patients with complement defects. Biselli, R., Casapollo, I., D'Amelio, R., Salvato, S., Matricardi, P.M., Brai, M. Scand. J. Immunol. (1993) [Pubmed]
  18. Chemokine patterns in meningococcal disease. Møller, A.S., Bjerre, A., Brusletto, B., Joø, G.B., Brandtzaeg, P., Kierulf, P. J. Infect. Dis. (2005) [Pubmed]
  19. Expression and involvement of Toll-like receptors (TLR)2, TLR4, and CD14 in monocyte TNF-alpha production induced by lipopolysaccharides from Neisseria meningitidis. Mirlashari, M.R., Lyberg, T. Med. Sci. Monit. (2003) [Pubmed]
  20. Interleukin-8 in serum and cerebrospinal fluid from patients with meningococcal disease. Halstensen, A., Ceska, M., Brandtzaeg, P., Redl, H., Naess, A., Waage, A. J. Infect. Dis. (1993) [Pubmed]
  21. Properdin deficiency in a family with fulminant meningococcal infections. Sjöholm, A.G., Braconier, J.H., Söderström, C. Clin. Exp. Immunol. (1982) [Pubmed]
  22. Continued tumor necrosis factor receptor expression by trauma patients' monocytes (Mphi) despite TNF alpha secretion. Miller-Graziano, C.L., Kodys, K., Gonzalez, F., Fudem, G.M. Shock (1994) [Pubmed]
  23. Long term effects of vaccination of patients deficient in a late complement component with a tetravalent meningococcal polysaccharide vaccine. Platonov, A.E., Vershinina, I.V., Kuijper, E.J., Borrow, R., Käyhty, H. Vaccine (2003) [Pubmed]
  24. The latency of serum acute phase proteins in meningococcal septicemia, with special emphasis on lactoferrin. Gutteberg, T.J., Haneberg, B., Jørgensen, T. Clin. Chim. Acta (1984) [Pubmed]
  25. Late osteoarticular lesions following meningococcemia with disseminated intravascular coagulation. Santos, E., Boavida, J.E., Barroso, A., Seabra, J., Carmona da Mota, H. Pediatric radiology. (1989) [Pubmed]
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