The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Metanephrine     4-(1-hydroxy-2-methylamino- ethyl)-2...

Synonyms: Metadrenaline, CHEMBL775, SureCN136702, BSPBio_000164, HMDB04063, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Metanephrine


Psychiatry related information on Metanephrine


High impact information on Metanephrine


Chemical compound and disease context of Metanephrine


Biological context of Metanephrine


Anatomical context of Metanephrine


Associations of Metanephrine with other chemical compounds


Gene context of Metanephrine

  • Preoperative measurement of plasma free metanephrine and neck ultrasonography always should be done if the diagnosis of MTC is known preoperatively [28].
  • COX-1(-/-) had a 89% reduction (P<0.0001) in the excretion of TxB2, a 76% reduction (P<0.01) in PGE2, a 40% reduction (P<0.0002) in 6-ketoPGF1alpha (6keto), a 27% reduction (P<0.02) in 11-betaPGF2alpha (11beta), a 35% reduction (P<0.01) in nitrate plus nitrite (NOx), and a 52% increase in metanephrine (P<0.02) [29].
  • Children with TBI also showed a higher excretion of metanephrine in the resting situation in comparison to children with ADHD and controls [30].
  • Total metanephrine values for most patients were appreciably lower than values obtained by the comparison procedure, that of Pisano (Clin. Chim. Acta 5: 406, 1970); however, results obtained by the two methods for two patients with pheochromocytomas agreed well [31].
  • The significance of any difference in the free catecholamine or total metanephrine concentrations in the different groups was assessed by one-way ANOVA [32].

Analytical, diagnostic and therapeutic context of Metanephrine

  • METHODS: Plasma metanephrine as well as plasma and urinary catecholamine concentrations were measured by high-performance liquid chromatography with electrochemical detection [33].
  • Patients with fever and pheochromocytoma were significantly more likely to have a comorbid event, larger tumor, necrosis within the tumor, higher urinary metanephrine levels, longer duration of hospitalization prior to surgery, and to be non-white [34].
  • To validate the clinical usefulness of this assay, we compared measurement of metanephrine by radioimmunoassay and of total urinary metanephrines by the Pisano colorimetric method [35].
  • Comparison with a routine HPLC method (n = 192) by Deming regression yielded a slope of 1.00 +/- 0.02 microg/L, an intercept of -5.8 +/- 7.8 micro/L, and S(y/x) = 50.6 microg/L for metanephrine and a slope of 0.94 +/- 0.03, intercept of 19 +/- 11 microg/L, and S(y/x) = 60 microg/L for normetanephrine [36].
  • Enzyme immunoassays based on microtiter plate technology have recently been developed for the quantitative determination of urinary metanephrine (M) and normetanephrine (NM) [37].


  1. Adrenomedullary dysplasia and hypofunction in patients with classic 21-hydroxylase deficiency. Merke, D.P., Chrousos, G.P., Eisenhofer, G., Weise, M., Keil, M.F., Rogol, A.D., Van Wyk, J.J., Bornstein, S.R. N. Engl. J. Med. (2000) [Pubmed]
  2. Plasma normetanephrine and metanephrine for detecting pheochromocytoma in von Hippel-Lindau disease and multiple endocrine neoplasia type 2. Eisenhofer, G., Lenders, J.W., Linehan, W.M., Walther, M.M., Goldstein, D.S., Keiser, H.R. N. Engl. J. Med. (1999) [Pubmed]
  3. The urinary metanephrine-to-creatinine ratio for the diagnosis of pheochromocytoma. Héron, E., Chatellier, G., Billaud, E., Foos, E., Plouin, P.F. Ann. Intern. Med. (1996) [Pubmed]
  4. Defective biliary excretion of epinephrine metabolites in mutant (TR-) rats: relation to the pathogenesis of black liver in the Dubin-Johnson syndrome and Corriedale sheep with an analogous excretory defect. Kitamura, T., Alroy, J., Gatmaitan, Z., Inoue, M., Mikami, T., Jansen, P., Arias, I.M. Hepatology (1992) [Pubmed]
  5. Single-voided urine metanephrine assays in screening for pheochromocytoma. Kaplan, N.M., Kramer, N.J., Holland, O.B., Sheps, S.G., Gomez-Sanchez, C. Arch. Intern. Med. (1977) [Pubmed]
  6. Adrenergic hyperactivity and metanephrine excess in the nucleus accumbens after prefrontocortical dopamine depletion. Espejo, E.F., Miñano, J. J. Neurophysiol. (2001) [Pubmed]
  7. Relationships between urinary catecholamine metabolites, particularly MHPG, and selected personality and physical fitness characteristics in normal subjects. Sothmann, M.S., Ismail, A.H. Psychosomatic medicine. (1984) [Pubmed]
  8. Snuff-induced hypertension in pheochromocytoma. McPhaul, M., Punzi, H.A., Sandy, A., Borganelli, M., Rude, R., Kaplan, N.M. JAMA (1984) [Pubmed]
  9. Loss of heterozygosity suggests multiple genetic alterations in pheochromocytomas and medullary thyroid carcinomas. Khosla, S., Patel, V.M., Hay, I.D., Schaid, D.J., Grant, C.S., van Heerden, J.A., Thibodeau, S.N. J. Clin. Invest. (1991) [Pubmed]
  10. The causes of dilated cardiomyopathy: a clinicopathologic review of 673 consecutive patients. Kasper, E.K., Agema, W.R., Hutchins, G.M., Deckers, J.W., Hare, J.M., Baughman, K.L. J. Am. Coll. Cardiol. (1994) [Pubmed]
  11. Pretreatment neurotransmitter metabolite levels and response to tricyclic antidepressant drugs. Maas, J.W., Koslow, S.H., Katz, M.M., Bowden, C.L., Gibbons, R.L., Stokes, P.E., Robins, E., Davis, J.M. The American journal of psychiatry. (1984) [Pubmed]
  12. Diabetes as a marker of pheochromocytoma in hypertensive patients. La Batide-Alanore, A., Chatellier, G., Plouin, P.F. J. Hypertens. (2003) [Pubmed]
  13. Advances in catecholamine and metabolite measurements for diagnosis of pheochromocytoma. Rosano, T.G., Swift, T.A., Hayes, L.W. Clin. Chem. (1991) [Pubmed]
  14. Influence of calorie source on the physiological response to parenteral nutrition in malnourished rabbits. García-Domingo, M., Lladó, L., Guirao, X., Franch, G., Oliva, A., Muñoz, A., Salas, E., Sancho, J.J., Sitges-Serra, A. Clinical nutrition (Edinburgh, Scotland) (1994) [Pubmed]
  15. Use of metyrosine in the anaesthetic management of patients with catecholamine-secreting tumours. A case report. Triner, L., Baer, L., Gallagher, R., Weitzman, S. British journal of anaesthesia. (1982) [Pubmed]
  16. Factors associated with perioperative morbidity and mortality in patients with pheochromocytoma: analysis of 165 operations at a single center. Plouin, P.F., Duclos, J.M., Soppelsa, F., Boublil, G., Chatellier, G. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  17. Adrenomedullary function may predict phenotype and genotype in classic 21-hydroxylase deficiency. Charmandari, E., Eisenhofer, G., Mehlinger, S.L., Carlson, A., Wesley, R., Keil, M.F., Chrousos, G.P., New, M.I., Merke, D.P. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  18. The relationships of free to conjugated normetanephrine in plasma and spinal fluid of hypertensive patients. Foti, A., Adachi, M., DeQuattro, V. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  19. Involvement of uptake2 in the termination of activity of neurogenic noradrenaline in the rat isolated atrium. Bell, C., Grabsch, B. J. Physiol. (Lond.) (1976) [Pubmed]
  20. Alterations in the responses of the sympathetic nervous system and renin in borderline hypertension. Robertson, D., Shand, D.G., Hollifield, J.W., Nies, A.S., Frölich, J.C., Oates, J.A. Hypertension (1979) [Pubmed]
  21. Epinephrine is metabolized by the spinal meninges of monkeys and pigs. Kern, C., Mautz, D.S., Bernards, C.M. Anesthesiology (1995) [Pubmed]
  22. Differences between presynaptic and postsynaptic alpha-adrenoceptors in the isolated nictitating membrane of the cat: effects of metanephrine and tolazoline. Arbilla, S., Langer, S.Z. Br. J. Pharmacol. (1978) [Pubmed]
  23. Plasma metanephrine levels are decreased in type 1 diabetic patients with a severely impaired epinephrine response to hypoglycemia, indicating reduced adrenomedullary stores of epinephrine. De Galan, B.E., Tack, C.J., Willemsen, J.J., Sweep, C.G., Smits, P., Lenders, J.W. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  24. Pubertal and gender-related changes in the sympathoadrenal system in healthy children. Weise, M., Eisenhofer, G., Merke, D.P. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  25. Measurement of urinary metanephrines to screen for pheochromocytoma in an unselected hospital referral population. Brain, K.L., Kay, J., Shine, B. Clin. Chem. (2006) [Pubmed]
  26. Radioimmunoassay for free and conjugated urinary metanephrine. Lam, R.W., Artal, R., Fisher, D.A. Clin. Chem. (1977) [Pubmed]
  27. Interference by the 4-hydroxylated metabolite of propranolol with determination of metanephrines by the Pisano method. Chou, D., Tsuru, M., Holtzman, J.L., Eckfeldt, J.H. Clin. Chem. (1980) [Pubmed]
  28. Diagnosis and management of medullary thyroid carcinoma. Massoll, N., Mazzaferri, E.L. Clin. Lab. Med. (2004) [Pubmed]
  29. Cyclooxygenase-1-deficient mice have high sleep-to-wake blood pressure ratios and renal vasoconstriction. Kawada, N., Solis, G., Ivey, N., Connors, S., Dennehy, K., Modlinger, P., Hamel, R., Kawada, J.T., Imai, E., Langenbach, R., Welch, W.J., Wilcox, C.S. Hypertension (2005) [Pubmed]
  30. Catecholamine functioning in children with traumatic brain injuries and children with attention-deficit/hyperactivity disorder. Konrad, K., Gauggel, S., Schurek, J. Brain research. Cognitive brain research. (2003) [Pubmed]
  31. Urinary metanephrines as measured by liquid chromatography with an on-line post-column reaction detector. Flood, J.G., McComb, R.B. Clin. Chem. (1981) [Pubmed]
  32. Freedom from drug interference in new immunoassays for urinary catecholamines and metanephrines. Wassell, J., Reed, P., Kane, J., Weinkove, C. Clin. Chem. (1999) [Pubmed]
  33. Diagnostic efficacy of unconjugated plasma metanephrines for the detection of pheochromocytoma. Raber, W., Raffesberg, W., Bischof, M., Scheuba, C., Niederle, B., Gasic, S., Waldhäusl, W., Roden, M. Arch. Intern. Med. (2000) [Pubmed]
  34. Fever in pheochromocytoma. Gordon, D.L., Atamian, S.D., Brooks, M.H., Gattuso, P., Castelli, M.J., Valaitis, J., Thomas, W. Arch. Intern. Med. (1992) [Pubmed]
  35. Urinary metanephrine radioimmunoassay: comparison with the colorimetric assay. Raum, W.J., Swerdloff, R.S. Clin. Chem. (1981) [Pubmed]
  36. Rapid analysis of metanephrine and normetanephrine in urine by gas chromatography-mass spectrometry. Crockett, D.K., Frank, E.L., Roberts, W.L. Clin. Chem. (2002) [Pubmed]
  37. Evaluation of urinary metanephrine and normetanephrine enzyme immunoassay (ELISA) kits by comparison with isotope dilution mass spectrometry. Wolthers, B.G., Kema, I.P., Volmer, M., Wesemann, R., Westermann, J., Manz, B. Clin. Chem. (1997) [Pubmed]
WikiGenes - Universities