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MeSH Review

Multiple Endocrine Neoplasia Type 2b

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Disease relevance of Multiple Endocrine Neoplasia Type 2b


High impact information on Multiple Endocrine Neoplasia Type 2b


Chemical compound and disease context of Multiple Endocrine Neoplasia Type 2b


Biological context of Multiple Endocrine Neoplasia Type 2b


Anatomical context of Multiple Endocrine Neoplasia Type 2b

  • Here we took advantage of two rat pheochromocytoma-derived cell lines (PC12/MEN2A and PC12/MEN2B) to investigate whether Ret-induced nerve growth factor (NGF) unresponsiveness might involve impairment of ERK signaling [19].
  • The gold standards for diagnosis are histochemical study of the rectal mucosa and molecular analysis of RET, which in familial cases detects MEN 2B at a preclinical stage so that early total prophylactic thyroidectomy can be performed [20].

Gene context of Multiple Endocrine Neoplasia Type 2b


Analytical, diagnostic and therapeutic context of Multiple Endocrine Neoplasia Type 2b

  • RESULTS: Fifteen patients (MEN 2A [10], MEN 2B [2], VHL [3]) underwent laparotomy for cortical-sparing adrenalectomy [26].
  • Because the incidence of MCT in MEN-IIb is virtually 100%, a total thyroidectomy in high risk patients--even before clinical evidence of malignant tumours--may be the only hope of cure [27].
  • Early diagnosis of MEN IIb, which could be made by recognition of the typical clinical appearance, is of special importance because of the poor prognosis of MTC [28].
  • The boiling-water extract of the herb was administered to 12 healthy volunteers (9 men/3 women) at a dosage of 100 mg/kg the anthraquinone levels in plasma were determined with TLC, HPLC, and LC-MS [29].


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  2. RET proto-oncogene mutations in French MEN 2A and FMTC families. Schuffenecker, I., Billaud, M., Calender, A., Chambe, B., Ginet, N., Calmettes, C., Modigliani, E., Lenoir, G.M. Hum. Mol. Genet. (1994) [Pubmed]
  3. Germline mutation of RET codon 883 in two cases of de novo MEN 2B. Smith, D.P., Houghton, C., Ponder, B.A. Oncogene (1997) [Pubmed]
  4. DNA polymorphisms and conditions for SSCP analysis of the 20 exons of the ret proto-oncogene. Ceccherini, I., Hofstra, R.M., Luo, Y., Stulp, R.P., Barone, V., Stelwagen, T., Bocciardi, R., Nijveen, H., Bolino, A., Seri, M. Oncogene (1994) [Pubmed]
  5. Analysis of forced wheezes in asthma patients. Fiz, J.A., Jané, R., Izquierdo, J., Homs, A., García, M.A., Gomez, R., Monso, E., Morera, J. Respiration; international review of thoracic diseases. (2006) [Pubmed]
  6. A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. Hofstra, R.M., Landsvater, R.M., Ceccherini, I., Stulp, R.P., Stelwagen, T., Luo, Y., Pasini, B., Höppener, J.W., van Amstel, H.K., Romeo, G. Nature (1994) [Pubmed]
  7. Development of medullary thyroid carcinoma in transgenic mice expressing the RET protooncogene altered by a multiple endocrine neoplasia type 2A mutation. Michiels, F.M., Chappuis, S., Caillou, B., Pasini, A., Talbot, M., Monier, R., Lenoir, G.M., Feunteun, J., Billaud, M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  8. Parent-of-origin effects in multiple endocrine neoplasia type 2B. Carlson, K.M., Bracamontes, J., Jackson, C.E., Clark, R., Lacroix, A., Wells, S.A., Goodfellow, P.J. Am. J. Hum. Genet. (1994) [Pubmed]
  9. Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells. Yuan, Z.L., Guan, Y.J., Wang, L., Wei, W., Kane, A.B., Chin, Y.E. Mol. Cell. Biol. (2004) [Pubmed]
  10. Somatic and MEN 2A de novo mutations identified in the RET proto-oncogene by screening of sporadic MTC:s. Zedenius, J., Wallin, G., Hamberger, B., Nordenskjöld, M., Weber, G., Larsson, C. Hum. Mol. Genet. (1994) [Pubmed]
  11. The multiple endocrine neoplasia type 2B point mutation alters long-term regulation and enhances the transforming capacity of the epidermal growth factor receptor. Pandit, S.D., Donis-Keller, H., Iwamoto, T., Tomich, J.M., Pike, L.J. J. Biol. Chem. (1996) [Pubmed]
  12. RET activation by germline MEN2A and MEN2B mutations. Borrello, M.G., Smith, D.P., Pasini, B., Bongarzone, I., Greco, A., Lorenzo, M.J., Arighi, E., Miranda, C., Eng, C., Alberti, L. Oncogene (1995) [Pubmed]
  13. Studies on the role of sex steroids in the feedback control of gonadotropin concentrations in men. III. Androgen resistance in primary gonadal failure. Winters, S.J., Sherins, R.J., Loriaux, D.L. J. Clin. Endocrinol. Metab. (1979) [Pubmed]
  14. Iodine 123 metaiodobenzylguanidine radio-guided navigation surgery for recurrent medullary thyroid carcinoma in a girl with multiple endocrine neoplasia type 2B. Shimotake, T., Tsuda, T., Aoi, S., Fumino, S., Iwai, N. J. Pediatr. Surg. (2005) [Pubmed]
  15. Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B. Carlson, K.M., Dou, S., Chi, D., Scavarda, N., Toshima, K., Jackson, C.E., Wells, S.A., Goodfellow, P.J., Donis-Keller, H. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  16. Increased in vivo phosphorylation of ret tyrosine 1062 is a potential pathogenetic mechanism of multiple endocrine neoplasia type 2B. Salvatore, D., Melillo, R.M., Monaco, C., Visconti, R., Fenzi, G., Vecchio, G., Fusco, A., Santoro, M. Cancer Res. (2001) [Pubmed]
  17. Nuclear factor-kappaB is constitutively active in C-cell carcinoma and required for RET-induced transformation. Ludwig, L., Kessler, H., Wagner, M., Hoang-Vu, C., Dralle, H., Adler, G., Böhm, B.O., Schmid, R.M. Cancer Res. (2001) [Pubmed]
  18. The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck. Bocciardi, R., Mograbi, B., Pasini, B., Borrello, M.G., Pierotti, M.A., Bourget, I., Fischer, S., Romeo, G., Rossi, B. Oncogene (1997) [Pubmed]
  19. Abrogation of nerve growth factor-induced terminal differentiation by ret oncogene involves perturbation of nuclear translocation of ERK. Colucci-D'Amato, G.L., D'Alessio, A., Califano, D., Cali, G., Rizzo, C., Nitsch, L., Santelli, G., de Franciscis, V. J. Biol. Chem. (2000) [Pubmed]
  20. Diagnostic and therapeutic approach to multiple endocrine neoplasia type 2B in pediatric patients. Torre, M., Martucciello, G., Ceccherini, I., Lerone, M., Aicardi, M., Gambini, C., Jasonni, V. Pediatr. Surg. Int. (2002) [Pubmed]
  21. Multiple endocrine neoplasia (MEN IIB) with Cushing's syndrome due to medullary thyroid carcinoma producing corticotropin-releasing hormone. Tagliabue, M., Pagani, A., Palestini, N., Manieri, C., Martina, V. Panminerva medica. (1996) [Pubmed]
  22. A human yeast artificial chromosome containing the multiple endocrine neoplasia type 2B Ret mutation does not induce medullary thyroid carcinoma but does support the growth of kidneys and partially rescues enteric nervous system development in Ret-deficient mice. Skinner, M.A., Kalyanaraman, S., Safford, S.D., Heuckeroth, R.O., Tourtellotte, W., Goyeau, D., Goodfellow, P., Milbrandt, J.D., Freemerman, A. Am. J. Pathol. (2005) [Pubmed]
  23. RET(Men2B)-transgene produces sympathoadrenal tumors but does not prevent intestinal aganglionosis in gdnf-/- or gfr alpha-1(-/-) mice. Rajan, I., Gestblom, C., Kapur, R.P. Pediatr. Dev. Pathol. (2001) [Pubmed]
  24. Multiple endocrine neoplasia type 2B mutation in human RET oncogene induces medullary thyroid carcinoma in transgenic mice. Acton, D.S., Velthuyzen, D., Lips, C.J., Höppener, J.W. Oncogene (2000) [Pubmed]
  25. ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma. Vidal, M., Wells, S., Ryan, A., Cagan, R. Cancer Res. (2005) [Pubmed]
  26. Cortical-sparing adrenalectomy for patients with bilateral pheochromocytoma. Lee, J.E., Curley, S.A., Gagel, R.F., Evans, D.B., Hickey, R.C. Surgery (1996) [Pubmed]
  27. Multiple endocrine neoplasia type IIb: a clinicopathological report. Van Zyl, J.A., Muller, G.S., Rossouw, D.J., Van Velden, D.J. Journal of surgical oncology. (1990) [Pubmed]
  28. Importance of early diagnosis and follow-up in multiple endocrine neoplasia (MEN II B). Frank, K., Raue, F., Gottswinter, J., Heinrich, U., Meybier, H., Ziegler, R. Eur. J. Pediatr. (1984) [Pubmed]
  29. Pharmacokinetic analysis of rhein in Rheum undulatum L. Lee, J.H., Kim, J.M., Kim, C. Journal of ethnopharmacology. (2003) [Pubmed]
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