Disease relevance of Research Support

• The National Institute on Alcohol Abuse and Alcoholism (NIAAA) supports research to elucidate the specific genetic factors, now largely unknown, which underlie susceptibility to alcoholism and its medical complications (including fetal alcohol syndrome) [1].
• PURPOSE: Research supports an association between aerobic fitness and cognitive functioning in chronic obstructive pulmonary disease (COPD) patients [2].
• CONCLUSION: A significant body of scientific research supports the use of cosmeceuticals containing vitamin C. Cutaneous benefits include promoting collagen synthesis, photoprotection from ultraviolet A and B, lightening hyperpigmentation, and improvement of a variety of inflammatory dermatoses [3].
• Current research supports the hypothesis that migraines are a response to a pineal circadian irregularity in which the administration of melatonin normalizes this circadian cycle; i.e., melatonin may play a role in resynchronizing biological rhythms to lifestyle and subsequently relieve migraines and other forms of headaches [4].
• The off-label use of gabapentin for indications not approved by the FDA should be reserved for cases where there is solid research support (e.g., diabetic neuropathy and prophylaxis of frequent migraine headaches) [5].

Psychiatry related information on Research Support

• Several lines of research support an important role for brain serotonin (5-HT) neurotransmitter systems in the control of alcohol drinking behaviour [6].
• SIGNIFICANCE: This research supports the idea that experience and practice are associated with changes in behavioral and EEG correlates of task performance and have clinical implications in disorders such as stroke or dystonia [7].

High impact information on Research Support

• Lithium is unmatched in research support for long-term clinical effectiveness against morbidity and mortality associated with depression or mania in bipolar I and II disorders [8].
• The Protein Information Resource (PIR; http://www-nbrf.georgetown. edu/pir/) supports research on molecular evolution, functional genomics, and computational biology by maintaining a comprehensive, non-redundant, well-organized and freely available protein sequence database [9].
• A growing body of research supports the view that choline is an essential nutrient during early development that has long-lasting effects on memory and attentional processes throughout the lifespan [10].
• RATIONALE: A great deal of research supports the role of nicotine in cigarette addiction [11].
• Recent research supports the view that the constitutive cleavage predominantly involves ADAM10 while the inducible one is mediated to a large extent by ADAM17 [12].

Biological context of Research Support

• Gender differences in nutrient and food intake were examined in Mexican Nutrition CRSP (Collaborative Research Support Program) infants (N = 75), preschoolers (N = 80), and school children (N = 91) [13].

Anatomical context of Research Support

• These data support research that suggests that reinforcing properties of cocaine are primarily mediated by DA release in the nucleus accumbens [14].
• Contemporary research supports the notion of a dysregulation in serotonin subsystems in the central nervous system, with target areas of dysfunction including basal ganglia and orbitofrontal cortex [15].
• Although the relationship between increased level of iron and p97 in the AD brain is not well understood, our research supports the hypothesis that p97 over-expressed by senile plaque associated reactive microglia is exocytosed and appears in blood [16].

Associations of Research Support with chemical compounds

• Preclinical research supports the hypothesis that elevations of mesolimbic DA mediate the addictive and reinforcing effects of methamphetamine and amphetamine [17].
• The results from our in vitro research support the role of antibiotic therapy for infection-induced atherosclerosis by indicating that azithromycin does actually improve endothelial function [18].
• A substantial amount of research supports the idea that brain acetaldehyde, produced by central ethanol metabolism, plays a key role in determining some of the behavioral effects of ethanol administration [19].
• The results from this research support the need to use CaCl2 to improve beef tenderness and consistency [20].
• Recent developments in atherosclerosis research support the introduction of progestogens such as desogestrel that allow the estrogenic increase in high density lipoprotein levels to persist and that may cause less of an elevation in plasma insulin responses to glucose [21].

Gene context of Research Support

• In conclusion, this research supports FSCN1 as a novel marker of NT2 neuronal differentiation and the possible role of CBP in its regulation [22].
• While previous research supports a role for both neuropeptides in the mediation of rodent emotional behaviors, there is currently a lack of information on the effects of central administration of NPY and GAL on fear- and anxiety-related behaviors in mice [23].
• A large body of research supports a pathogenic role of Th2 cells in allergic diseases such as asthma [24].
• Results of this research support theories of ADHD that focus on a frontal-striatal neurological circuitry substrate, which has been implicated in neuropsychological executive functioning [25].
• This research supports the initial hypothesis and shows that ovarian leptin receptor concentrations vary throughout the oestrous cycle in response to the changing environment of the ovary [26].

Analytical, diagnostic and therapeutic context of Research Support

• This review of the Nutrition Collaborative Research Support Program (Nutrition CRSP) describes the results of a longitudinal study of the effects of marginal malnutrition on human function in Egypt, Kenya, and Mexico. Growth-stunting occurred soon after birth and was associated with cognitive and behavioral deficits in infancy and childhood [27].

References