The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

FSCN1  -  fascin actin-bundling protein 1

Homo sapiens

Synonyms: 55 kDa actin-bundling protein, FAN1, FLJ38511, Fascin, HSN, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of FSCN1


High impact information on FSCN1

  • Formation of filopodia in coelomocytes: localization of fascin, a 58,000 dalton actin cross-linking protein [6].
  • Roles of fascin in cell adhesion and motility [7].
  • We propose that fascin is a key specific actin cross-linker, providing stiffness for filopodial bundles, and that its dynamic behavior allows for efficient coordination between elongation and bundling of filopodial actin filaments [8].
  • Analysis of cellular localization of known actin cross-linking proteins in mouse melanoma B16F1 cells revealed that fascin was specifically localized along the entire length of all filopodia, whereas other actin cross-linkers were not [8].
  • RNA interference of fascin reduced the number of filopodia, and remaining filopodia had abnormal morphology with wavy and loosely bundled actin organization [8].

Chemical compound and disease context of FSCN1

  • Several nonprimate cell lines (mink Mv-1-lu, rabbit SIRC, hamster a23, mouse NIH 3T3, cat CCC, and rat HSN) remained resistant to infection by LAV-2/B after treatment with glycosylation inhibitors, suggesting that they do not express the HIV-2 CD4-independent receptor [9].
  • Uptake in hooded rat sarcoma (HSN) cells, which express Pgp, is significantly increased in the presence of the MDR modulator cyclosporin A [10].
  • In this study, we prepared an ethanol extract from ripe fruits of SNL and investigated the mechanism involved in its growth-inhibitory effect on MCF-7 human breast cancer cells [11].
  • Upregulation of alpha 1 beta 1 integrin on mesangial regions in biopsy specimens in patients with HSN may be connected to the much more florid glomerular changes in renal tissue in this type of glomerulonephritis than in IgAN [12].

Biological context of FSCN1

  • Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility [13].
  • To understand the mechanism of fascin-actin interactions, we dissected the actin binding region and its regulatory site by phosphorylation of human fascin [14].
  • NG2- and fascin-positive structures are often localized to opposite poles of spreading cells, suggesting a possible role for the two classes of cellular extensions in the establishment of cell polarity during morphogenesis or migration [15].
  • The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer [16].
  • Although fascin expression was associated with the basal-like phenotype, it was not associated with their metastatic behavior [4].

Anatomical context of FSCN1


Associations of FSCN1 with chemical compounds

  • The lower amount of FSCN1 transcript in the absence of the CBP factor was also established in RA-treated cells [18].
  • Cells treated with genistein also spread and formed fascin-containing microspikes which tended to be more slender than those of control cells [19].
  • Indeed, although vanadate-treated cells tended to retract, the microspikes became more prominent and showed an increased intensity of staining for fascin [19].
  • In contrast, cells adherent on fibronectin displayed a complex rearrangement of the actin cytoskeleton and a transient enrichment of 55 kDa/fascin-containing structures at the cell surface when treated with sodium orthovanadate and hydrogen peroxide [19].
  • Both subcutaneous carbamazepine (0.5-22.5 mg/kg) and gabapentin (10-100 mg/kg) significantly reduced the spontaneous activity of spinal neurones of SNL rats at both PO time points [20].

Other interactions of FSCN1


Analytical, diagnostic and therapeutic context of FSCN1


  1. Phenotypes of Drosophila brain neurons in primary culture reveal a role for fascin in neurite shape and trajectory. Kraft, R., Escobar, M.M., Narro, M.L., Kurtis, J.L., Efrat, A., Barnard, K., Restifo, L.L. J. Neurosci. (2006) [Pubmed]
  2. Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation? Pinkus, G.S., Pinkus, J.L., Langhoff, E., Matsumura, F., Yamashiro, S., Mosialos, G., Said, J.W. Am. J. Pathol. (1997) [Pubmed]
  3. Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein. Mosialos, G., Birkenbach, M., Ayehunie, S., Matsumura, F., Pinkus, G.S., Kieff, E., Langhoff, E. Am. J. Pathol. (1996) [Pubmed]
  4. Prognostic significance of basal-like phenotype and fascin expression in node-negative invasive breast carcinomas. Rodríguez-Pinilla, S.M., Sarrió, D., Honrado, E., Hardisson, D., Calero, F., Benitez, J., Palacios, J. Clin. Cancer Res. (2006) [Pubmed]
  5. Rac regulates the interaction of fascin with protein kinase C in cell migration. Parsons, M., Adams, J.C. J. Cell. Sci. (2008) [Pubmed]
  6. Formation of filopodia in coelomocytes: localization of fascin, a 58,000 dalton actin cross-linking protein. Otto, J.J., Kane, R.E., Bryan, J. Cell (1979) [Pubmed]
  7. Roles of fascin in cell adhesion and motility. Adams, J.C. Curr. Opin. Cell Biol. (2004) [Pubmed]
  8. Role of fascin in filopodial protrusion. Vignjevic, D., Kojima, S., Aratyn, Y., Danciu, O., Svitkina, T., Borisy, G.G. J. Cell Biol. (2006) [Pubmed]
  9. Reduced glycosylation of human cell lines increases susceptibility to CD4-independent infection by human immunodeficiency virus type 2 (LAV-2/B). Talbot, S.J., Weiss, R.A., Schulz, T.F. J. Virol. (1995) [Pubmed]
  10. Copper bis(diphosphine) complexes: radiopharmaceuticals for the detection of multi-drug resistance in tumours by PET. Lewis, J.S., Dearling, J.L., Sosabowski, J.K., Zweit, J., Carnochan, P., Kelland, L.R., Coley, H.M., Blower, P.J. European journal of nuclear medicine. (2000) [Pubmed]
  11. Ripe fruit of Solanum nigrum L. inhibits cell growth and induces apoptosis in MCF-7 cells. Son, Y.O., Kim, J., Lim, J.C., Chung, Y., Chung, G.H., Lee, J.C. Food Chem. Toxicol. (2003) [Pubmed]
  12. Pattern of renal beta 1(alpha 1-alpha 6) integrins distribution in IgA nephropathy and Henoch-Schoenlein nephritis. Wagrowska-Danilewicz, M., Danilewicz, M. Polish journal of pathology : official journal of the Polish Society of Pathologists. (2002) [Pubmed]
  13. Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility. Anilkumar, N., Parsons, M., Monk, R., Ng, T., Adams, J.C. EMBO J. (2003) [Pubmed]
  14. Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin. Ono, S., Yamakita, Y., Yamashiro, S., Matsudaira, P.T., Gnarra, J.R., Obinata, T., Matsumura, F. J. Biol. Chem. (1997) [Pubmed]
  15. NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration. Lin, X.H., Grako, K.A., Burg, M.A., Stallcup, W.B. Mol. Biol. Cell (1996) [Pubmed]
  16. The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer. Bros, M., Ross, X.L., Pautz, A., Reske-Kunz, A.B., Ross, R. J. Immunol. (2003) [Pubmed]
  17. Phosphorylation of human fascin inhibits its actin binding and bundling activities. Yamakita, Y., Ono, S., Matsumura, F., Yamashiro, S. J. Biol. Chem. (1996) [Pubmed]
  18. Minor expression of fascin-1 gene (FSCN1) in NTera2 cells depleted of CREB-binding protein. Megiorni, F., Indovina, P., Mora, B., Mazzilli, M.C. Neurosci. Lett. (2005) [Pubmed]
  19. Formation of stable microspikes containing actin and the 55 kDa actin bundling protein, fascin, is a consequence of cell adhesion to thrombospondin-1: implications for the anti-adhesive activities of thrombospondin-1. Adams, J.C. J. Cell. Sci. (1995) [Pubmed]
  20. Effects of systemic carbamazepine and gabapentin on spinal neuronal responses in spinal nerve ligated rats. Chapman, V., Suzuki, R., Chamarette, H.L., Rygh, L.J., Dickenson, A.H. Pain (1998) [Pubmed]
  21. Sarcoma arising in hyaline-vascular castleman disease of skin and subcutis. Kazakov, D.V., Morrisson, C., Plaza, J.A., Michal, M., Suster, S. The American Journal of dermatopathology. (2005) [Pubmed]
  22. Polarized actin bundles formed by human fascin-1: their sliding and disassembly on myosin II and myosin V in vitro. Ishikawa, R., Sakamoto, T., Ando, T., Higashi-Fujime, S., Kohama, K. J. Neurochem. (2003) [Pubmed]
  23. Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer. Pelosi, G., Pastorino, U., Pasini, F., Maissoneuve, P., Fraggetta, F., Iannucci, A., Sonzogni, A., De Manzoni, G., Terzi, A., Durante, E., Bresaola, E., Pezzella, F., Viale, G. Br. J. Cancer (2003) [Pubmed]
  24. The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cells. Ross, R., Ross, X.L., Schwing, J., Längin, T., Reske-Kunz, A.B. J. Immunol. (1998) [Pubmed]
WikiGenes - Universities