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MeSH Review

Adrenal Cortex Neoplasms

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Disease relevance of Adrenal Cortex Neoplasms


High impact information on Adrenal Cortex Neoplasms


Chemical compound and disease context of Adrenal Cortex Neoplasms


Biological context of Adrenal Cortex Neoplasms


Anatomical context of Adrenal Cortex Neoplasms


Gene context of Adrenal Cortex Neoplasms

  • The putative role of OSM as an immunotherapeutic agent in human adrenocortical cancer remains to be elucidated [20].
  • Alterations of CRE binding proteins with loss of CREB expression and compensatory overexpression of CREMtau is observed in the human adrenocortical cancer cell line H295R [21].
  • The present investigation was performed in order to study the properties of abnormal membrane function related to ACTH receptor-adenylate cyclase system interaction in human ACTH-unresponsive adrenocortical cancer [22].
  • After surgery, MMP-8 and MMP-9 levels decreased significantly in patients with adrenocortical cancers, whereas the decrease of these MMPs in patients with benign tumors, although noticeable, was not statistically significant [23].
  • Adrenocortical cancers, like other cancers, typically have telomerase activity [24].

Analytical, diagnostic and therapeutic context of Adrenal Cortex Neoplasms


  1. Suramin in adrenocortical cancer: limited efficacy and serious toxicity. Arlt, W., Reincke, M., Siekmann, L., Winkelmann, W., Allolio, B. Clin. Endocrinol. (Oxf) (1994) [Pubmed]
  2. New insights in the genetics of adrenocortical tumors, pheochromocytomas and paragangliomas. Bertherat, J., Gimenez-Roqueplo, A.P. Horm. Metab. Res. (2005) [Pubmed]
  3. Gelatinase A and membrane-type 1 matrix metalloproteinase mRNA: expressed in adrenocortical cancers but not in adenomas. Kjellman, M., Enberg, U., Höög, A., Larsson, C., Holst, M., Farnebo, L.O., Sato, H., Bäckdahl, M. World journal of surgery. (1999) [Pubmed]
  4. Cholera toxin can ADP-ribosylate Gs as well as Gi in ACTH-unresponsive human adrenocortical cancer. Nishikawa, T., Yoshida, A., Omura, M., Sasano, H., Noda, M. Endocr. J. (1994) [Pubmed]
  5. High frequency of germline p53 mutations in childhood adrenocortical cancer. Wagner, J., Portwine, C., Rabin, K., Leclerc, J.M., Narod, S.A., Malkin, D. J. Natl. Cancer Inst. (1994) [Pubmed]
  6. Mutations of beta-catenin in adrenocortical tumors: activation of the Wnt signaling pathway is a frequent event in both benign and malignant adrenocortical tumors. Tissier, F., Cavard, C., Groussin, L., Perlemoine, K., Fumey, G., Hagneré, A.M., René-Corail, F., Jullian, E., Gicquel, C., Bertagna, X., Vacher-Lavenu, M.C., Perret, C., Bertherat, J. Cancer Res. (2005) [Pubmed]
  7. Decreased expression of cyclic adenosine monophosphate-regulated aldose reductase (AKR1B1) is associated with malignancy in human sporadic adrenocortical tumors. Lefrançois-Martinez, A.M., Bertherat, J., Val, P., Tournaire, C., Gallo-Payet, N., Hyndman, D., Veyssière, G., Bertagna, X., Jean, C., Martinez, A. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  8. Transcription factor 3',5'-cyclic adenosine 5'-monophosphate-responsive element-binding protein (CREB) is decreased during human adrenal cortex tumorigenesis and fetal development. Rosenberg, D., Groussin, L., Jullian, E., Perlemoine, K., Medjane, S., Louvel, A., Bertagna, X., Bertherat, J. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  9. Construction of gene therapy vectors targeting adrenocortical cells: enhancement of activity and specificity with agents modulating the cyclic adenosine 3',5'-monophosphate pathway. Chuman, Y., Zhan, Z., Fojo, T. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  10. Low-dose monitored mitotane treatment achieves the therapeutic range with manageable side effects in patients with adrenocortical cancer. Terzolo, M., Pia, A., Berruti, A., Osella, G., Alì, A., Carbone, V., Testa, E., Dogliotti, L., Angeli, A. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  11. A patient with adrenocortical carcinoma: characterization of its biological activity and drug resistance profile. Feller, N., Hoekman, K., Kuiper, C.M., Linn, S.C., Verheul, H.M., Wolthers, B.G., Popp-Snijders, C., Pinedo, H.M. Clin. Cancer Res. (1997) [Pubmed]
  12. Streptozocin and o,p'DDD in the treatment of adrenocortical cancer patients: long-term survival in its adjuvant use. Khan, T.S., Imam, H., Juhlin, C., Skogseid, B., Gröndal, S., Tibblin, S., Wilander, E., Oberg, K., Eriksson, B. Ann. Oncol. (2000) [Pubmed]
  13. Suramin and the human adrenocortex: results of experimental and clinical studies. Dorfinger, K., Niederle, B., Vierhapper, H., Astrid, W., Czernin, S., Nowotny, P., Waldhäusl, W., Grubeck-Loebenstein, B. Surgery (1991) [Pubmed]
  14. Molecular genetics of adrenocortical tumours, from familial to sporadic diseases. Libé, R., Bertherat, J. Eur. J. Endocrinol. (2005) [Pubmed]
  15. Prolonged bleeding time due to mitotane therapy. Haak, H.R., Caekebeke-Peerlinck, K.M., van Seters, A.P., Briët, E. Eur. J. Cancer (1991) [Pubmed]
  16. Antiestrogens upregulate estrogen receptor beta expression and inhibit adrenocortical H295R cell proliferation. Montanaro, D., Maggiolini, M., Recchia, A.G., Sirianni, R., Aquila, S., Barzon, L., Fallo, F., Andò, S., Pezzi, V. J. Mol. Endocrinol. (2005) [Pubmed]
  17. Evidence for androgen receptor gene expression and growth inhibitory effect of dihydrotestosterone on human adrenocortical cells. Rossi, R., Zatelli, M.C., Valentini, A., Cavazzini, P., Fallo, F., del Senno, L., degli Uberti, E.C. J. Endocrinol. (1998) [Pubmed]
  18. Role of transforming growth factor beta 1 (TGF beta 1) in mediating androgen-induced growth inhibition in human adrenal cortex in vitro. Zatelli, M.C., Rossi, R., del Senno, L., degli Uberti, E.C. Steroids (1998) [Pubmed]
  19. Biochemical and immunological characterization of estrogen binding components in human neoplastic adrenocortical tissues. Nakao, M., Sato, B., Koga, M., Noma, K., Kishimoto, S., Matsuda, M., Sonoda, T., Matsumoto, K. J. Steroid Biochem. (1986) [Pubmed]
  20. The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells. Auernhammer, C.J., Dorn, F., Vlotides, G., Hengge, S., Kopp, F.B., Spoettl, G., Cengic, N., Engelhardt, D., Weber, M.M. J. Endocrinol. (2004) [Pubmed]
  21. Role of the PKA-regulated transcription factor CREB in development and tumorigenesis of endocrine tissues. Rosenberg, D., Groussin, L., Jullian, E., Perlemoine, K., Bertagna, X., Bertherat, J. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  22. Evidence for decreased activity of guanine nucleotide binding protein in adenylate cyclase of cell membranes in human ACTH-unresponsive adrenocortical carcinoma. Yoshida, A., Nishikawa, T., Tamura, Y., Yoshida, S. Endocrinol. Jpn. (1986) [Pubmed]
  23. Evaluation of MMP-1, MMP-8, MMP-9 serum levels in patients with adrenal tumors prior to and after surgery. Kołomecki, K., Stepień, H., Bartos, M., Narebski, J. Neoplasma (2001) [Pubmed]
  24. Telomerase is not required for experimental tumorigenesis of human and bovine adrenocortical cells. Chen, M., Hawks, C.L., Huang, Q., Sun, B., Hornsby, P.J. Endocr. Res. (2004) [Pubmed]
  25. Feasibility of the association of mitotane with etoposide, adriamycin and cisplatin combination chemotherapy in advanced adrenocortical cancer patients. Report on 7 cases. Pia, A., Berruti, A., Terzolo, M., Paccotti, P., Letizia, C., Dogliotti, L., Angeli, A. Ann. Oncol. (1995) [Pubmed]
  26. Antiproliferative effect of suramin on primary cultures of human pheochromocytomas and rat PC12 pheochromocytoma cells. Zielke, A., Wong, M.G., Siperstein, A.E., Clark, O.H., Rothmund, M., Duh, Q.Y. Journal of surgical oncology. (1997) [Pubmed]
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