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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Pulpotomy

  • In the present study, 24 permanent teeth of individuals, aged 10-22 years and diagnosed as hyperplastic pulpitis were treated by pulpotomy using an atraumatic surgical technique with calcium hydroxide alone [1].

High impact information on Pulpotomy

  • In conclusion, calcium hydroxide is less appropriate for pulpotomies than is formocresol [2].
  • As part of an overall evaluation of possible substitutes for the pulpotomy agent formocresol, this study was initiated to compare the antigenicity of the reaction products of protein with formaldehyde, glutaraldehyde, or dimethylsuberimidate (DMS) [3].
  • Our findings suggest that if non-immunogenicity of a pulpotomy agent is a desirable property, then DMS does not meet the criteria of an alternative pulp fixative [3].
  • The aim of the present study was to investigate the neuropeptide CGRP in order to determine the effect on dentin bridge formation during the healing process after pulpotomy [4].
  • Neurotensin-like immunoreactivity in odontoblasts and their processes in rat maxillary molar teeth and the effect of pulpotomy [5].

Chemical compound and disease context of Pulpotomy


Anatomical context of Pulpotomy


Associations of Pulpotomy with chemical compounds


Gene context of Pulpotomy

  • The results indicate that the three cresol isomers are effective ROS scavengers and may prevent ROS induced damage when used as pulpotomy agents or as intracanal medicaments [20].
  • The enzymes lactate dehydrogenase (LD), succinate dehydrogenase (SD), alkaline phosphatase (AP), and glucose-6-phosphate dehydrogenase (G-6-PD) were evaluated at specific locations in pulp tissue following glutaraldehyde pulpotomies [21].
  • Alternative dressings for formocresol pulpotomies such as 6.25% glutaraldehyde solution, antigen-extracted allogeneic dentin matrix, and crude bone morphogenetic protein are reported with promising results [22].

Analytical, diagnostic and therapeutic context of Pulpotomy


  1. Success of pulpotomy in the management of hyperplastic pulpitis. Caliskan, M.K. International endodontic journal. (1993) [Pubmed]
  2. Effectiveness of 4 pulpotomy techniques--randomized controlled trial. Huth, K.C., Paschos, E., Hajek-Al-Khatar, N., Hollweck, R., Crispin, A., Hickel, R., Folwaczny, M. J. Dent. Res. (2005) [Pubmed]
  3. The effect of alternatives to formocresol on antigenicity of proteins. Ranly, D.M., Horn, D., Zislis, T. J. Dent. Res. (1985) [Pubmed]
  4. CGRP immunohistochemistry in wound healing and dentin bridge formation following rat molar pulpotomy. Zhang, M., Fukuyama, H. Histochem. Cell Biol. (1999) [Pubmed]
  5. Neurotensin-like immunoreactivity in odontoblasts and their processes in rat maxillary molar teeth and the effect of pulpotomy. Bhatnagar, M., Cintra, A., Tinner, B., Agnati, L.F., Kerezoudis, N., Edwall, L., Fuxe, K. Regul. Pept. (1995) [Pubmed]
  6. Assessment of the systemic distribution and toxicity of glutaraldehyde as a pulpotomy agent. Ranly, D.M., Horn, D., Hubbard, G.B. Pediatric dentistry. (1989) [Pubmed]
  7. Evidence-based assessment: evaluation of the formocresol versus ferric sulfate primary molar pulpotomy. Loh, A., O'Hoy, P., Tran, X., Charles, R., Hughes, A., Kubo, K., Messer, L.B. Pediatric dentistry. (2004) [Pubmed]
  8. Formocresol and ferric sulfate have similar success rates in primary molar pulpotomy. In carious primary molars does a pulpotomy performed with ferric sulphate, compared with formocresol, result in greater clinical/radiographic success? Deery, C. Evidence-based dentistry. (2005) [Pubmed]
  9. Ferric sulphate and formocresol pulpotomies in baboon primary molars: histological responses. Cleaton-Jones, P., Duggal, M., Parak, M., William, S., Setze, S. European journal of paediatric dentistry : official journal of European Academy of Paediatric Dentistry. (2002) [Pubmed]
  10. Inhibition of cyclooxygenase activity, platelet aggregation and thromboxane B2 production by two environmental toxicants: m- and o-cresol. Chan, C.P., Yuan-Soon, H., Wang, Y.J., Lan, W.H., Chen, L.I., Chen, Y.J., Lin, B.R., Chang, M.C., Jeng, J.H. Toxicology (2005) [Pubmed]
  11. Healing process of dog dental pulp after pulpotomy and pulp covering with calcium hydroxide in powder or paste form. Holland, R., de Mello, W., Nery, M.J., de Souza, V., Bernabe, P.F., Otoboni Filho, J.A. Acta de odontología pediátrica. (1981) [Pubmed]
  12. Electrocoagulation extends the indication of calcium hydroxide pulpotomy in the primary dentition. Sasaki, H., Ogawa, T., Koreeda, M., Ozaki, T., Sobue, S., Ooshima, T. The Journal of clinical pediatric dentistry. (2002) [Pubmed]
  13. The effect of pulpotomy using CO2 and Nd:YAG lasers on dental pulp tissue. Jukić, S., Anić, I., Koba, K., Najzar-Fleger, D., Matsumoto, K. International endodontic journal. (1997) [Pubmed]
  14. Results of crown-height reduction and partial coronal pulpectomy in rhesus monkeys (Macaca mulatta). Lommer, M.J., Verstraete, F.J. Comp. Med. (2001) [Pubmed]
  15. Systemic absorption of 14C-glutaraldehyde from glutaraldehyde-treated pulpotomy sites. Myers, D.R., Pashley, D.H., Lake, F.T., Burnham, D., Kalathoor, S., Waters, R. Pediatric dentistry. (1986) [Pubmed]
  16. Radiographic success of ferric sulfate and formocresol pulpotomies in relation to early exfoliation. Vargas, K.G., Packham, B. Pediatric dentistry. (2005) [Pubmed]
  17. Periodontal changes following coronal/root perforation and formocresol pulpotomy. Abrams, H., Cunningham, C.J., Lee, S.B. Journal of endodontics. (1992) [Pubmed]
  18. Success of an alternative for interim management of irreversible pulpitis. McDougal, R.A., Delano, E.O., Caplan, D., Sigurdsson, A., Trope, M. Journal of the American Dental Association (1939) (2004) [Pubmed]
  19. Calcium hydroxide pulpotomy for primary teeth: a clinical study. Heilig, J., Yates, J., Siskin, M., McKnight, J., Turner, J. Journal of the American Dental Association (1939) (1984) [Pubmed]
  20. Scavenging property of three cresol isomers against H2O2, hypochlorite, superoxide and hydroxyl radicals. Yeung, S.Y., Lan, W.H., Huang, C.S., Lin, C.P., Chan, C.P., Chang, M.C., Jeng, J.H. Food Chem. Toxicol. (2002) [Pubmed]
  21. The effect of glutaraldehyde pulpotomy treatment on pulpal enzymes. Hill, S.D., Seale, N.S., Quintero, E.M., Guo, I.Y. Pediatric dentistry. (1993) [Pubmed]
  22. Pulp therapy in the primary dentition. Fuks, A.B., Eidelman, E. Current opinion in dentistry. (1991) [Pubmed]
  23. Current and potential pulp therapies for primary and young permanent teeth. Ranly, D.M., Garcia-Godoy, F. Journal of dentistry. (2000) [Pubmed]
  24. Pulp treatment for extensive decay in primary teeth. Nadin, G., Goel, B.R., Yeung, C.A., Glenny, A.M. Cochrane database of systematic reviews (Online) (2003) [Pubmed]
  25. The effect of pulp capping and pulpotomy on hard tissue bridges of contaminated pulps. Heide, S. International endodontic journal. (1991) [Pubmed]
  26. Follow-up study of permanent incisors with complicated crown fractures after acute trauma. Ravn, J.J. Scandinavian journal of dental research. (1982) [Pubmed]
  27. Histological evaluation of electrosurgery and formocresol pulpotomy techniques in primary teeth in dogs. El-Meligy, O., Abdalla, M., El-Baraway, S., El-Tekya, M., Dean, J.A. The Journal of clinical pediatric dentistry. (2001) [Pubmed]
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