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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Oligomenorrhea


High impact information on Oligomenorrhea

  • Seven of the 10 postpubertal, premenopausal women (70 percent) had oligomenorrhea, and 5 (50 percent) had low serum estradiol concentrations [6].
  • We conclude that there is familial aggregation of hyperandrogenemia (with or without oligomenorrhea) in PCOS kindreds [7].
  • Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial [8].
  • A diagnosis of PCOS was based on 1) oligomenorrhea, 2) hyperandrogenism (biochemical or clinical), and 3) exclusion of other related disorders [9].
  • Other than a tendency toward a larger MOV, a higher incidence of oligomenorrhea, obesity, and frequency of neurological disorders, recovery of the reproductive axis after GnRH analog therapy was not markedly different in HH compared to IPP [10].

Chemical compound and disease context of Oligomenorrhea


Biological context of Oligomenorrhea


Anatomical context of Oligomenorrhea

  • On the basis of the patient's hormonal status and studies of the literature, the author advances the hypothesis of a defect in the steroid receptor proteins in the congenitally somewhat deformed uterus, in explanation of these patients' oligomenorrhea [19].

Gene context of Oligomenorrhea


Analytical, diagnostic and therapeutic context of Oligomenorrhea


  1. Detection of functional ovarian hyperandrogenism in women with androgen excess. Ehrmann, D.A., Rosenfield, R.L., Barnes, R.B., Brigell, D.F., Sheikh, Z. N. Engl. J. Med. (1992) [Pubmed]
  2. Low-dose flutamide-metformin therapy reverses insulin resistance and reduces fat mass in nonobese adolescents with ovarian hyperandrogenism. Ibáñez, L., Ong, K., Ferrer, A., Amin, R., Dunger, D., de Zegher, F. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  3. Obesity and oligomenorrhea are associated with hyperandrogenism independent of hirsutism. Hosseinian, A.H., Kim, M.H., Rosenfield, R.L. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  4. Pulsatile intravenous gonadotropin-releasing hormone for ovulation-induction in infertile women. I. Safety and effectiveness with outpatient therapy. Jansen, R.P., Handelsman, D.J., Boylan, L.M., Conway, A., Shearman, R.P., Fraser, I.S. Fertil. Steril. (1987) [Pubmed]
  5. Pituitary responses to synthetic luteinizing hormone-releasing hormone in thirty-four cases of amenorrhea or oligomenorrhea associated with galactorrhea. van Campenhout, J., Papas, S., Blanchet, P., Wyman, H., Somma, M. Am. J. Obstet. Gynecol. (1977) [Pubmed]
  6. Hypothalamic-pituitary dysfunction after radiation for brain tumors. Constine, L.S., Woolf, P.D., Cann, D., Mick, G., McCormick, K., Raubertas, R.F., Rubin, P. N. Engl. J. Med. (1993) [Pubmed]
  7. Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome. Legro, R.S., Driscoll, D., Strauss, J.F., Fox, J., Dunaif, A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  8. Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial. Fleming, R., Hopkinson, Z.E., Wallace, A.M., Greer, I.A., Sattar, N. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  9. Prevalence of polycystic ovary syndrome among premenopausal women with type 2 diabetes. Peppard, H.R., Marfori, J., Iuorno, M.J., Nestler, J.E. Diabetes Care (2001) [Pubmed]
  10. Reproductive axis after discontinuation of gonadotropin-releasing hormone analog treatment of girls with precocious puberty: long term follow-up comparing girls with hypothalamic hamartoma to those with idiopathic precocious puberty. Feuillan, P.P., Jones, J.V., Barnes, K., Oerter-Klein, K., Cutler, G.B. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  11. Postpubertal outcome in girls diagnosed of premature pubarche during childhood: increased frequency of functional ovarian hyperandrogenism. Ibañez, L., Potau, N., Virdis, R., Zampolli, M., Terzi, C., Gussinyé, M., Carrascosa, A., Vicens-Calvet, E. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  12. Ovarian 17-hydroxyprogesterone hyperresponsiveness to gonadotropin-releasing hormone (GnRH) agonist challenge in women with polycystic ovary syndrome is not mediated by luteinizing hormone hypersecretion: evidence from GnRH agonist and human chorionic gonadotropin stimulation testing. Ibañez, L., Hall, J.E., Potau, N., Carrascosa, A., Prat, N., Taylor, A.E. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  13. Bone mineralization, hypothalamic amenorrhea, and sex steroid therapy in female adolescents and young adults. Hergenroeder, A.C. J. Pediatr. (1995) [Pubmed]
  14. Ovulation induction with pulsatile luteinizing releasing hormone in women with clomiphene citrate-resistant polycystic ovary-like disease: clinical results. Burger, C.W., Korsen, T.J., Hompes, P.G., van Kessel, H., Schoemaker, J. Fertil. Steril. (1986) [Pubmed]
  15. The relationship between the pituitary response to luteinizing hormone-releasing hormone and the ovulatory response to clomiphene citrate. Feore, J.C., Taymor, M.L. Fertil. Steril. (1976) [Pubmed]
  16. Predicting recurring miscarriage: what is important? Quenby, S.M., Farquharson, R.G. Obstetrics and gynecology. (1993) [Pubmed]
  17. Effective bromocriptine treatment of a pituitary macroadenoma during pregnancy. Maeda, T., Ushiroyama, T., Okuda, K., Fujimoto, A., Ueki, M., Sugimoto, O. Obstetrics and gynecology. (1983) [Pubmed]
  18. Combined gonadotropin-releasing hormone analog and exogenous gonadotropins for ovulation induction in infertile women: efficacy related to ovarian function assessment. Fleming, R., Haxton, M.J., Hamilton, M.P., Conaghan, C.J., Black, W.P., Yates, R.W., Coutts, J.R. Am. J. Obstet. Gynecol. (1988) [Pubmed]
  19. Minor müllerian anomalies and oligomenorrhea in infertile women. A new syndrome. Sørensen, S.S. Am. J. Obstet. Gynecol. (1981) [Pubmed]
  20. Effect of epimestrol on gonadotropin and prolactin plasma levels and response to luteinizing hormone-releasing hormone/thyrotropin-releasing hormone in secondary amenorrhea and oligomenorrhea. Genazzani, A.R., Facchinetti, F., de Leo, V., Picciolini, E., Franchi, F., Parrini, D., Kicovic, P.M. Fertil. Steril. (1978) [Pubmed]
  21. New concepts in anorexia nervosa. Muñoz, M.T., Argente, J. Journal of pediatric endocrinology & metabolism : JPEM. (2004) [Pubmed]
  22. The natural history of untreated hyperprolactinemia: a prospective analysis. Schlechte, J., Dolan, K., Sherman, B., Chapler, F., Luciano, A. J. Clin. Endocrinol. Metab. (1989) [Pubmed]
  23. Follow-up study of male and female offspring of DES-exposed mothers. Bibbo, M., Gill, W.B., Azizi, F., Blough, R., Fang, V.S., Rosenfield, R.L., Schumacher, G.F., Sleeper, K., Sonek, M.G., Wied, G.L. Obstetrics and gynecology. (1977) [Pubmed]
  24. Serum IGF-I is higher in gymnasts than runners and predicts bone and lean mass. Snow, C.M., Rosen, C.J., Robinson, T.L. Medicine and science in sports and exercise. (2000) [Pubmed]
  25. A specific elevation in tissue plasminogen activator antigen in women with polycystic ovarian syndrome. Kelly, C.J., Lyall, H., Petrie, J.R., Gould, G.W., Connell, J.M., Rumley, A., Lowe, G.D., Sattar, N. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  26. Impaired uterine perfusion associated with metabolic disorders in women with polycystic ovary syndrome. Chekir, C., Nakatsuka, M., Kamada, Y., Noguchi, S., Sasaki, A., Hiramatsu, Y. Acta obstetricia et gynecologica Scandinavica. (2005) [Pubmed]
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