Disease relevance of o-Hydroxyhippuric acid

• Isolation and chemical characterization of 2-hydroxybenzoylglycine as a drug binding inhibitor in uremia [1].
• The apparent in vivo KM and Vmax for salicylurate formation, on a body weight basis, were at the adult level [2].
• Areas under the unbound plasma concentration-time curve were larger and the fractional excretion of salicyluric acid was lower in children with kwashiorkor compared with control individuals [3].

Psychiatry related information on o-Hydroxyhippuric acid

• However, the effect of water deprivation was uniform at the two dose levels without any effect on the excretion of salicyluric acid [4].

High impact information on o-Hydroxyhippuric acid

• Since 2-hydroxybenzoylglycine has been chemically defined to be a major drug binding inhibitor in uremia, a search for the presence of a similar compound in the sera of newborn infants was made [5].
• It is concluded that 2-hydroxybenzoylglycine plays an important role in drug binding defects observed in the newborn, and the inhibitor may also play a part in the precipitation of bilirubin-induced neurotoxicity in neonates when the substance is abnormally elevated [5].
• Salicylic acid and salicyluric acid concentrations in plasma and urine were measured by HPLC [6].
• GU was also formed by the rat liver microsomal hydroxylation of salicyluric acid, and phenobarbital pretreatment increased this formation [7].
• The rate of formation of salicyl phenolic glucuronide and salicyluric acid are easily saturated at low salicylic acid concentrations and their formation is described by Michaelis-Menten kinetics [8].

Biological context of o-Hydroxyhippuric acid

• There is also evidence that enzyme induction of salicyluric acid formation occurs [8].
• No significant effect on cell proliferation was ascertained with salicyluric acid [9].
• A second objective was to determine the effect of 2-hydroxybenzoylglycine (HBG) on the protein binding of ceftriaxone [10].
• Plasma salicylate and urine salicylurate levels were measured by high-pressure liquid chromatography at frequent intervals following dosing; the resultant profiles, areas under the curve (AUC), and percentages of dose excreted as salicylurate were statistically analyzed by an analysis of variance [11].
• 1. The pharmacokinetics of salicylic acid (SA) and its major metabolite salicyluric acid (SU) were studied in nine patients with rheumatoid arthritis following a 900 mg oral dose of acetylsalicylic acid and during 6 weeks of chronic administration of enteric coated aspirin (3,900 mg day) [12].

Anatomical context of o-Hydroxyhippuric acid

• Timed samples of blood and semen were obtained from each subject, and the concentrations of aspirin, salicylic acid, and salicyluric acid determined by a specific high-performance liquid chromatographic assay [13].
• An assay is reported for salicylic acid and two of its metabolites, salicyluric acid and gentisic acid, in mouse and rat blood, urine, and feces and rat embryos [14].
• The surface character of the duodenal, jejunal, ileal, caecal and colonic mucosa were almost identical compared with the control following the treatment with salicyluric acid [15].
• Immediate and very extensive salicylic acid formation in the cecum was found following intracecal administration of salicyluric acid [16].
• The transport of aspirin (ASP) and its metabolites (salicylic acid (SA), salicyluric acid (SAU), gentisic acid (GA) and gentisuric acid (GAU)) through human erythrocyte membrane was investigated [17].

Associations of o-Hydroxyhippuric acid with other chemical compounds

• High-pressure liquid chromatography analysis of salicylic acid, salicyluric acid, and gentisic acid in biological matrixes [14].
• The formation of the methyl ester of salicyluric acid was observed during the quantitation of salicyluric acid and other salicylate metabolites in urine by high-pressure liquid chromatography [18].
• Two known metabolites of aspirin, salicyluric acid and gentisuric acid, are also substrates for PAM, leading to the formation of salicylamide and gentisamide [19].
• Excretion of salicyluric acid decreased with increasing dose, whereas gentisic acid and salicyl phenolic and acyl glucuronides increased [20].
• In order to quantify the effect of probenecid on the plasma kinetics and the renal handling of salicyluric acid, we conceived a dynamic model, able to describe changes in plasma kinetics as well as in urinary excretion [21].

Gene context of o-Hydroxyhippuric acid

• Induction of salicyluric acid formation in rheumatoid arthritis patients treated with salicylates [22].
• The established method is also used to analyze gentisic (GA), salicyluric (SUA) and salicylic acid (SA), not only after intake of Willow Bark capsules (Assalix, BNO 1455) but also as naturally occurring constituents in human plasma after the intake of salicylic acid containing foods [23].

Analytical, diagnostic and therapeutic context of o-Hydroxyhippuric acid

• From analytical studies including ultraviolet and fluorescence spectroscopy, gas chromatography, chemical ionization and electron impact mass spectrometry, and proton nuclear magnetic resonance spectroscopy, the chemical structure of the uremic binding inhibitor was deduced to be 2-hydroxybenzoylglycine [1].
• Kinetics of aspirin, salicylic acid, and salicyluric acid following oral administration of aspirin as a tablet and two buffered solutions [24].
• Twelve fasting normal volunteers received three aspirin dosage forms in a single-dose, complete crossover study; the plasma and urine levels of aspirin, salicylic acid, and salicyluric acid were measured for 10 hr [24].
• After rectal administration, a small amount of salicyluric acid was absorbed in intact form [25].
• The separation of acetylsalicylic acid and three of its metabolites--salicylic acid, salicyluric acid and gentisic acid--is demonstrated in a non-aqueous capillary electrophoresis system with reversed electroosmotic flow [26].

References