Chemical Compound Review:
kelatorphan (2S)-2-[[(2R)-2-benzyl-3...
Synonyms:
CHEMBL85320, KB-78017, AR-1K2951, LS-186814, LS-187482, ...
- Antinociceptive effect of systemic kelatorphan, in mononeuropathic rats, involves different opioid receptor types. Lee, S.H., Kayser, V., Guilbaud, G. Eur. J. Pharmacol. (1994)
- Comparison of selective and complete inhibitors of enkephalin-degrading enzymes on morphine withdrawal syndrome. Maldonado, R., Daugé, V., Callebert, J., Villette, J.M., Fournié-Zaluski, M.C., Feger, J., Roques, B.P. Eur. J. Pharmacol. (1989)
- Inhibition of enkephalin metabolism and activation of mu- or delta-opioid receptors elicit opposite effects on reward and motility in the ventral mesencephalon. Heidbreder, C., Gewiss, M., Lallemand, S., Roques, B.P., De Witte, P. Neuropharmacology (1992)
- Kelatorphan, a potent enkephalinases inhibitor, and opioid receptor agonists DAGO and DTLET, differentially modulate self-stimulation behaviour depending on the site of administration. de Witte, P., Heidbreder, C., Roques, B.P. Neuropharmacology (1989)
- Phosphoramidon blocks the pressor activity of porcine big endothelin-1-(1-39) in vivo and conversion of big endothelin-1-(1-39) to endothelin-1-(1-21) in vitro. McMahon, E.G., Palomo, M.A., Moore, W.M., McDonald, J.F., Stern, M.K. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Phosphoramidon-sensitive conversion of big endothelin-1 and degradation of endothelin-1 in rat kidney. Fujita, K., Matsumura, Y., Kita, S., Hisaki, K., Takaoka, M., Morimoto, S. Hypertension (1994)
- Effects of the potent analgesic enkephalin-catabolizing enzyme inhibitors RB101 and kelatorphan on respiration. Boudinot, E., Morin-Surun, M., Foutz, A.S., Fournié-Zaluski, M., Roques, B.P., Denavit-Saubié, M. Pain (2001)
- Effects of Kelatorphan and morphine before and after noxious stimulation on immediate-early gene expression in rat spinal cord neurons. Tölle, T.R., Schadrack, J., Castro-Lopes, J.M., Evan, G., Roques, B.P., Zieglgänsberger, W. Pain (1994)
- Potentiation of enkephalin action by peptidase inhibitors in rat locus ceruleus in vitro. Williams, J.T., Christie, M.J., North, R.A., Roques, B.P. J. Pharmacol. Exp. Ther. (1987)
- Prolonged analgesia by enkephalinase inhibition in rats with spinal cord adrenal medullary transplants. Sagen, J., Wang, H. Eur. J. Pharmacol. (1990)
- Bidentate peptides: highly potent new inhibitors of enkephalin degrading enzymes. Bouboutou, R., Waksman, G., Devin, J., Fournié-Zaluski, M.C., Roques, B.P. Life Sci. (1984)
- Comparison of the behavioural effects induced by administration in rat nucleus accumbens or nucleus caudatus of selective mu and delta opioid peptides or kelatorphan an inhibitor of enkephalin-degrading-enzymes. Daugé, V., Rossignol, P., Roques, B.P. Psychopharmacology (Berl.) (1988)
- Opioid and GABA receptors involved in mediation and modulation of tonic and stimulus-evoked inhibition of a spinal reflex in the decerebrated and spinalized rabbit. Clarke, R.W., Bhandari, R.N., Leggett, J. Neuropharmacology (2001)
- Control of breathing by endogenous opioid peptides: possible involvement in sudden infant death syndrome. Morin-Surun, M.P., Boudinot, E., Fournie-Zaluski, M.C., Champagnat, J., Roques, B.P., Denavit-Saubie, M. Neurochem. Int. (1992)
- Effects of kelatorphan and other peptidase inhibitors on the in vitro and in vivo release of methionine-enkephalin-like material from the rat spinal cord. Bourgoin, S., Le Bars, D., Artaud, F., Clot, A.M., Bouboutou, R., Fournie-Zaluski, M.C., Roques, B.P., Hamon, M., Cesselin, F. J. Pharmacol. Exp. Ther. (1986)
- Kelatorphan potentiates the effect of [Met5]enkephalin in the substantia gelatinosa of the cat spinal cord. Morton, C.R., Zhao, Z.Q., Duggan, A.W. Eur. J. Pharmacol. (1987)
- Effect of endopeptidase-24.11 inhibitors and C-ANP receptor ligand on responses evoked in arterioles of rat cremaster muscle by atrial natriuretic peptide. Peyroux, J., Beslot, F., Claperon, N., Fournie-Zaluski, M.C., Roques, B.P. Br. J. Pharmacol. (1995)
- Evidence that endogenous enkephalins and a delta opioid receptor agonist have a common site of action in spinal antinociception. Dickenson, A.H., Sullivan, A.F., Roques, B.P. Eur. J. Pharmacol. (1988)
- Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice. Michael-Titus, A., Dourmap, N., Costentin, J., Schwartz, J.C. Neuropeptides (1990)
- New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties. Fournié-Zaluski, M.C., Coulaud, A., Bouboutou, R., Chaillet, P., Devin, J., Waksman, G., Costentin, J., Roques, B.P. J. Med. Chem. (1985)
- Retrograde axonal transport of neurotensin in the dopaminergic nigrostriatal pathway in the rat. Castel, M.N., Malgouris, C., Blanchard, J.C., Laduron, P.M. Neuroscience (1990)
- Endogenous opioids are involved in the genetically determined high preference for ethanol consumption. George, S.R., Roldan, L., Lui, A., Naranjo, C.A. Alcohol. Clin. Exp. Res. (1991)
- Dopamine depletion augments endogenous opioid-induced locomotion in the nucleus accumbens using both mu 1 and delta opioid receptors. Churchill, L., Roques, B.P., Kalivas, P.W. Psychopharmacology (Berl.) (1995)