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Chemical Compound Review

BSPBio_002774     4-[ (1R,3S,5S,10S,11R,13R,14S,17S) -1,5,11...

Synonyms: KBioGR_002272, CCG-39760, NINDS_000905, SPBio_001128, NSC-757425, ...
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Disease relevance of ouabain


High impact information on ouabain


Biological context of ouabain


Anatomical context of ouabain

  • Experiments in which 24-Na, amiloride, or sodium-free mucosal solutions were used, revealed that a large, though variable, percentage of the sodium gained by cells exposed to oubain, came from the mucosal medium, a finding consistent with the model of passive sodium entry from the mucosal medium followed by active sodium extrusion to the serosa [12].
  • 5. Phosphoprotein formation and ATP-ADP phosphate exchange are not affected by azide, dinitrophenol, dicyclohexyl carbodiimide and oubain, whilst both activities are reduced by blockade of -SH groups localized on the outside of the sarcoplasmic reticulum membrane [13].
  • The ultrastructural cytochemical localization of a potassium-dependent oubain-sensitive nitrophenyl phosphatase (transport ATPase) activity in human blood platelets is described [14].
  • A panel of three bispecific monoclonal antibodies (bsMAbs) binding to follitropin (FSH) and to beta-galactosidase have been prepared by fusion of hybridoma cell lines resistant to oubain and neomycin [15].
  • Different sensitivities of acetylcholine-induced "after-hyperpolarization" compared to dopamine-induced hyperpolarization, to oubain or to lithium-replacement of sodium, in rabbit sympathetic ganglia [16].

Associations of ouabain with other chemical compounds


Gene context of ouabain


  1. Brain 'ouabain' and desensitization of arterial baroreflex by high sodium in Dahl salt-sensitive rats. Huang, B.S., Leenen, F.H. Hypertension (1995) [Pubmed]
  2. Effects of hypoxia on the contractions and lactate release induced by high-K+, ouabain and epinephrine in guinea-pig aorta. Nasu, T., Zakimi, S., Shibata, H. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1991) [Pubmed]
  3. A comparison of the effects of quinetholate, lidocaine and procainamide on ouabain-induced ventricular tachycardia and cardiac function. Taylor, S.E., Nash, C.B. Archives internationales de pharmacodynamie et de thérapie. (1978) [Pubmed]
  4. Selective depolarization of interneurons in the early posttraumatic dentate gyrus: involvement of the Na(+)/K(+)-ATPase. Ross, S.T., Soltesz, I. J. Neurophysiol. (2000) [Pubmed]
  5. Lack of genetic damage in mammalian cells after cryopreservation at -196 degrees C. Ashwood-Smith, M.J. Exp. Hematol. (1979) [Pubmed]
  6. Interdependence of ion transport and the action of quabain in heart muscle. Bentfeld, M., Lüllmann, H., Peters, T., Proppe, D. Br. J. Pharmacol. (1977) [Pubmed]
  7. Glucose uptake and metabolism in the Trichinella spiralis nurse cell. Montgomery, J.M., Augostini, P., Stewart, G.L. Int. J. Parasitol. (2003) [Pubmed]
  8. The effect of general anesthetic agents, ouabain, and aldosterone on striated muscle contraction in toad. Amaranath, L., Andersen, N.B. Anesth. Analg. (1976) [Pubmed]
  9. Ionophores have limited effects on jejunal glucose absorption and energy metabolism in mice. Fan, Y.K., Croom, J., Eisen, E.J., Spires, H.R., Daniel, L.R. J. Anim. Sci. (2003) [Pubmed]
  10. Cell growth and quabain-sensitive 86Rg+ uptake and (Na++K+)-ATPase activity in 3T3 and SV40 transformed 3T3 fibroblasts. Kimelberg, H.K., Mayhew, E. Biochim. Biophys. Acta (1976) [Pubmed]
  11. Gender differences in selected zinc metabolism parameters in patients with mild primary arterial hypertension. Tubek, S. Biological trace element research (2006) [Pubmed]
  12. Some effects of ouabain on cellular ions and water in epithelial cells of toad urinary bladder. Macknight, A.D., Civan, M.M., Leaf, A. J. Membr. Biol. (1975) [Pubmed]
  13. Characterization of cardiac sarcoplasmic reticulum ATP-ADP phosphate exchange and phosphorylation of the calcium transport adenosine triphosphatase. Suko, J., Hasselbach, W. Eur. J. Biochem. (1976) [Pubmed]
  14. Cytochemical localization of ouabain-sensitive (K+)-dependent p-nitrophenyl phosphatase (transport ATPase) in human blood platelets. Cutler, L.S., Feinstein, M.B., Christian, C.P. J. Histochem. Cytochem. (1980) [Pubmed]
  15. Antigen binding properties of highly purified bispecific antibodies. Allard, W.J., Moran, C.A., Nagel, E., Collins, G., Largen, M.T. Mol. Immunol. (1992) [Pubmed]
  16. Different sensitivities of acetylcholine-induced "after-hyperpolarization" compared to dopamine-induced hyperpolarization, to oubain or to lithium-replacement of sodium, in rabbit sympathetic ganglia. Libet, B., Tanaka, T., Tosaka, T. Life Sci. (1977) [Pubmed]
  17. Characterization of differentiation-inducer-resistant HL-60 cells. Gallagher, R.E., Bilello, P.A., Ferrari, A.C., Chang, C.S., Yen, R.W., Nickols, W.A., Muly, E.C. Leuk. Res. (1985) [Pubmed]
  18. Effects of glibenclamide, metformin and insulin on the incidence and latency of death by oubain-induced arrhythmias in mice. Yazar, A., Polat, G., Un, I., Levent, A., Kaygusuz, A., Büyükafşar, K., çamdeviren, H. Pharmacol. Res. (2002) [Pubmed]
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