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Chemical Compound Review

Cloroben     1,2-dichlorobenzene

Synonyms: Rotamott, Chloroben, Chloroden, Termitkil, Dizene, ...
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Disease relevance of Dilatin DB


High impact information on Dilatin DB


Chemical compound and disease context of Dilatin DB


Biological context of Dilatin DB


Anatomical context of Dilatin DB


Associations of Dilatin DB with other chemical compounds


Gene context of Dilatin DB

  • There was a relationship between the liver damage induced by 1,2-dichlorobenzene and the immunosuppressive effect of mice sera on the AFC response [18].
  • 1,2-dichlorobenzene is not a 'toxic, persistent and liable to bioaccumulate' substance sensu the Oslo and Paris Convention for the Prevention of Marine Pollution (OSPAR-DYNAMEC) criteria [24].
  • This risk assessment on 1,2-dichlorobenzene was carried out for the marine environment, following methodology given in the EU risk assessment Regulation (1488/94) and Guidance Document of the EU New and Existing Substances Regulation (TGD, 1996) [24].

Analytical, diagnostic and therapeutic context of Dilatin DB

  • Three previously reported procedures for the synthesis of pure C(s)-C60Cl6 from C60 and ICl dissolved in benzene or 1,2-dichlorobenzene were shown to actually yield complex mixtures of products that contain, at best, 54-80% C(s)-C60Cl6 based on HPLC integrated intensities [25].
  • A stable solution of individual SWNTs in o-dichlorobenzene was obtained by a combination of ultrasonication and ultracentrifugation [26].


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  2. A physiologically based pharmacokinetic (PB-PK) model for 1,2-dichlorobenzene linked to two possible parameters of toxicity. Hissink, A.M., Van Ommen, B., Krüse, J., Van Bladeren, P.J. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  3. Dermatitis from orthodichlorobenzene in a leather dye. Wright, R.C. Contact Derm. (1979) [Pubmed]
  4. Reply to the comments by Coenraads and Tang 'Chloracne due to o-dichlorobenzene in a laboratory worker', Contact Dermatitis 2005: 52: 108. Violante, F.S., Milani, S., Malenchini, G., Barbieri, A. Contact Derm. (2005) [Pubmed]
  5. Teratogenic potential of inhaled dichlorobenzenes in rats and rabbits. Hayes, W.C., Hanley, T.R., Gushow, T.S., Johnson, K.A., John, J.A. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1985) [Pubmed]
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  7. Orientational effect on the photophysical properties of quaterthiophene-C60 dyads. van Hal, P.A., Beckers, E.H., Meskers, S.C., Janssen, R.A., Jousselme, B., Blanchard, P., Roncali, J. Chemistry (Weinheim an der Bergstrasse, Germany) (2002) [Pubmed]
  8. Cyclization of 1-(2-alkynylphenyl)-3,3-dialkyltriazenes: a convenient, high-yield synthesis of substituted cinnolines and isoindazoles. Kimball, D.B., Weakley, T.J., Haley, M.M. J. Org. Chem. (2002) [Pubmed]
  9. Differences in cytochrome P450-mediated biotransformation of 1,2-dichlorobenzene by rat and man: implications for human risk assessment. Hissink, A.M., Oudshoorn, M.J., Van Ommen, B., Haenen, G.R., Van Bladeren, P.J. Chem. Res. Toxicol. (1996) [Pubmed]
  10. The role of hepatocellular oxidative stress in Kupffer cell activation during 1,2-dichlorobenzene-induced hepatotoxicity. Younis, H.S., Parrish, A.R., Glenn Sipes, I. Toxicol. Sci. (2003) [Pubmed]
  11. Enhancement of biodegradability of polychlorinated dibenzo-p-dioxins. Du, X., Zhu, N., Xia, X., Bao, Z., Xu, X. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. (2001) [Pubmed]
  12. 1,2-Dichlorobenzene-induced lipid peroxidation in male Fischer 344 rats is Kupffer cell dependent. Hoglen, N.C., Younis, H.S., Hartley, D.P., Gunawardhana, L., Lantz, R.C., Sipes, I.G. Toxicol. Sci. (1998) [Pubmed]
  13. Dose-dependent kinetics and metabolism of 1,2-dichlorobenzene in rat: effect of pretreatment with phenobarbital. Hissink, A.M., Van Ommen, B., Van Bladeren, P.J. Xenobiotica (1996) [Pubmed]
  14. Antimitotic intervention with colchicine alters the outcome of o-DCB-induced hepatotoxicity in Fischer 344 rats. Kulkarni, S.G., Warbritton, A., Bucci, T.J., Mehendale, H.M. Toxicology (1997) [Pubmed]
  15. Reductive deamination as a new step in the anaerobic microbial degradation of halogenated anilines. Travkin, V., Baskunov, B.P., Golovlev, E.L., Boersma, M.G., Boeren, S., Vervoort, J., van Berkel, W.J., Rietjens, I.M., Golovleva, L.A. FEMS Microbiol. Lett. (2002) [Pubmed]
  16. Variable temperature infrared spectroscopy of cytosine-guanine base pairs: tautomerism versus polarization. MacPhail, R.A., Williams, L.D., Jones, D.A., Shaw, B.R. J. Biomol. Struct. Dyn. (1992) [Pubmed]
  17. Modulation of 1,2-dichlorobenzene hepatotoxicity in the Fischer-344 rat by a scavenger of superoxide anions and an inhibitor of Kupffer cells. Gunawardhana, L., Mobley, S.A., Sipes, I.G. Toxicol. Appl. Pharmacol. (1993) [Pubmed]
  18. Serum-borne factor(s) of 1,1-dichloroethylene and 1,2-dichlorobenzene-treated mice inhibited in vitro antibody forming cell response and natural killer cell activity. Ban, M., Hettich, D., Goutet, M., Binet, S. Toxicol. Lett. (1998) [Pubmed]
  19. Cytochrome P450 catalyzed oxidation of monochlorobenzene, 1,2- and 1,4-dichlorobenzene in rat, mouse, and human liver microsomes. Nedelcheva, V., Gut, I., Soucek, P., Frantík, E. Chem. Biol. Interact. (1998) [Pubmed]
  20. Inflammatory damage to skin by prolonged contact with 1,2-dichlorobenzene and chloropentafluorobenzene. McDougal, J.N., Grabau, J.H., Dong, L., Mattie, D.R., Jepson, G.W. Microsc. Res. Tech. (1997) [Pubmed]
  21. Human cytochrome P450 enzyme selectivities in the oxidation of chlorinated benzenes. Bogaards, J.J., van Ommen, B., Wolf, C.R., van Bladeren, P.J. Toxicol. Appl. Pharmacol. (1995) [Pubmed]
  22. Halogen...halogen interactions in pressure-frozen ortho- and meta-dichlorobenzene isomers. Bujak, M., Dziubek, K., Katrusiak, A. Acta Crystallogr., B (2007) [Pubmed]
  23. A comparison of the acute neuroactive effects of dichloromethane, 1,3-dichloropropane, and 1,2-dichlorobenzene on rat flash evoked potentials (FEPs). Herr, D.W., Boyes, W.K. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1997) [Pubmed]
  24. 1,2-dichlorobenzene marine risk assessment with special reference to the OSPARCOM region: North Sea. van Wijk, D., Thompson, R.S., De Rooij, C., Garny, V., Lecloux, A., Kanne, R. Environmental monitoring and assessment. (2004) [Pubmed]
  25. Seven-minute synthesis of pure C(s)-C60Cl6 from [60]fullerene and iodine monochloride: first IR, Raman, and mass spectra of 99 mol % C60Cl6. Kuvychko, I.V., Streletskii, A.V., Popov, A.A., Kotsiris, S.G., Drewello, T., Strauss, S.H., Boltalina, O.V. Chemistry (Weinheim an der Bergstrasse, Germany) (2005) [Pubmed]
  26. Individualization of single-walled carbon nanotubes: is the solvent important? Kim, D.S., Nepal, D., Geckeler, K.E. Small (Weinheim an der Bergstrasse, Germany) (2005) [Pubmed]
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