Disease relevance of Dilatin DB

• Degradation of 1,2-dichlorobenzene by a Pseudomonas sp [1].
• A physiologically based pharmacokinetic (PB-PK) model for 1,2-dichlorobenzene linked to two possible parameters of toxicity [2].
• Dermatitis from orthodichlorobenzene in a leather dye [3].
• Reply to the comments by Coenraads and Tang 'Chloracne due to o-dichlorobenzene in a laboratory worker', Contact Dermatitis 2005: 52: 108 [4].
• Maternal toxicity, as evidenced by a significant decrease in body weight gain, was observed in all groups of ODCB-exposed rats and liver weight was significantly increased in the 400-ppm ODCB-exposed group [5].

High impact information on Dilatin DB

• The reactions of single-walled carbon nanotubes (SWNTs) with succinic or glutaric acid acyl peroxides in o-dichlorobenzene at 80-90 degrees C resulted in the addition of 2-carboxyethyl or 3-carboxypropyl groups, respectively, to the sidewalls of the SWNT [6].
• In the more polar ODCB, direct electron transfer from 4T(S1) competes with energy transfer, and both direct and indirect charge transfers are observed [7].
• Replacing MeI with 1,2-dichlorobenzene as solvent allows for the general cyclization of (2-ethynylphenyl)dialkyltriazenes [8].
• Differences in cytochrome P450-mediated biotransformation of 1,2-dichlorobenzene by rat and man: implications for human risk assessment [9].
• The role of hepatocellular oxidative stress in Kupffer cell activation during 1,2-dichlorobenzene-induced hepatotoxicity [10].

Chemical compound and disease context of Dilatin DB

• The biodegradability of TrCDD and tetra-chlorinated dibenzo-p-dioxin (TCDD) by the strain Pseudomonas sp. EE41, a new isolated one, could be enhanced through primary nutrient of co-metabolism of o-dichlorobenzene (o-DCB) [11].

Biological context of Dilatin DB

• 1,2-Dichlorobenzene-induced lipid peroxidation in male Fischer 344 rats is Kupffer cell dependent [12].
• Dose-dependent kinetics and metabolism of 1,2-dichlorobenzene in rat: effect of pretreatment with phenobarbital [13].
• Interstrain difference in compensatory tissue repair has been suggested as the underlying mechanism for the lack of strain differences in lethality (S.G. Kulkarni, H. Duong, R. Gomila, and H.M. Mehendale, Strain differences in tissue repair response to 1,2-dichlorobenzene. Archives of Toxicology 1996; 70: 714-723) [14].
• Most interesting is the observation of reductive deamination and the formation of 1,2-dichlorobenzene as one of the intermediates [15].
• The IR spectra in the OH and NH stretching region indicate formation of hydrogen-bonded CG base pairs and self associates in 1,2-dichlorobenzene over a temperature range from 10 to 290K [16].

Anatomical context of Dilatin DB

• Modulation of 1,2-dichlorobenzene hepatotoxicity in the Fischer-344 rat by a scavenger of superoxide anions and an inhibitor of Kupffer cells [17].
• Serum-borne factor(s) of 1,1-dichloroethylene and 1,2-dichlorobenzene-treated mice inhibited in vitro antibody forming cell response and natural killer cell activity [18].
• We studied metabolism of monochlorobenzene (MCB), 1,2-dichlorobenzene (1,2-DCB) and 1,4-DCB in liver microsomes from untreated male and female Wistar rats and B6C3F1 mice or in those after the induction of CYP3A or 2E1 as well as in human male liver microsomes [19].

Associations of Dilatin DB with other chemical compounds

• Skin samples from Fischer-344 rats and Hartley guinea pigs exposed dermally to 1,2-dichlorobenzene (DCB) and chloropentafluorobenzene (CPFB) for up to 4 h were examined for chemical-induced damage [20].
• The ratio between the activities of CYP2E1 and CYP3A4 with respect to the oxidation of chlorinated benzenes decreased from 150 (1,2-dichlorobenzene) to 1.8 (pentachlorobenzene) [21].
• In order to estimate the relative contribution of CYP2E1 in hepatic metabolism of 1,2-dichlorobenzene and 1,2,4-trichlorobenzene in vitro, the rate of oxidation of these compounds by microsomal preparations from 22 human livers was correlated with activities toward specific substrates for CYP2E1, CYP3A, and CYP1A [21].
• Isomers 1,2-dichlorobenzene (o-DCB) and 1,3-dichlorobenzene (m-DCB) were high-pressure frozen in-situ in a Merrill-Bassett diamond-anvil cell and their structures determined at room temperature and at 0.18 (5) GPa for o-DCB, and 0.17 (5) GPa for m-DCB by single-crystal X-ray diffraction [22].
• The present experiments compared the effects of DCM (log P = 1.25; oil:water partition coefficient), 1,3-dichloropropane (DCP; log P = 2.00), and 1,2-dichlorobenzene (DCB; log P = 3.38) on FEPs recorded from adult Long-Evans rats [23].

Gene context of Dilatin DB

• There was a relationship between the liver damage induced by 1,2-dichlorobenzene and the immunosuppressive effect of mice sera on the AFC response [18].
• 1,2-dichlorobenzene is not a 'toxic, persistent and liable to bioaccumulate' substance sensu the Oslo and Paris Convention for the Prevention of Marine Pollution (OSPAR-DYNAMEC) criteria [24].
• This risk assessment on 1,2-dichlorobenzene was carried out for the marine environment, following methodology given in the EU risk assessment Regulation (1488/94) and Guidance Document of the EU New and Existing Substances Regulation (TGD, 1996) [24].

Analytical, diagnostic and therapeutic context of Dilatin DB

• Three previously reported procedures for the synthesis of pure C(s)-C60Cl6 from C60 and ICl dissolved in benzene or 1,2-dichlorobenzene were shown to actually yield complex mixtures of products that contain, at best, 54-80% C(s)-C60Cl6 based on HPLC integrated intensities [25].
• A stable solution of individual SWNTs in o-dichlorobenzene was obtained by a combination of ultrasonication and ultracentrifugation [26].

References