Disease relevance of Nurelle

• A series of spontaneous 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) nonmetabolizing mutants of Pseudomonas cepacia AC1100 were characterized to be defective in either 2,4,5-T uptake or conversion of this compound to 2,4,5-trichlorophenol (2,4,5-TCP) [1].
• Copper-mediated toxicity of 2,4,5-trichlorophenol: biphasic effect of the copper(I)-specific chelator neocuproine [2].
• Effects of hypoxia on valve-closure time and bioaccumulation of 2,4,5-trichlorophenol by the freshwater clam Sphaerium corneum [L.] [3].
• Burkholderia cepacia strain AC1100 can be induced for the degradation of 2,4,5-trichlorophenol (2,4,5-TCP) [4].

Psychiatry related information on Nurelle

• The herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) and two structurally related compounds, phenoxyacetic acid and 2,4,5-trichlorophenol, were suspended in a 1:1 solution of honey:water and administered by gavage to pregnant mice on one of gestation days 8-15 (copulation plug day = day 1) or on three consecutive days (7-9, 10-12, or 13-15) [5].

High impact information on Nurelle

• The Arabidopsis type 1 UDP-glucose-dependent glucosyltransferase UGT72B1 is highly active in conjugating the persistent pollutants 3,4-dichloroaniline (DCA) and 2,4,5-trichlorophenol (TCP) [6].
• Biological monitoring of 2,4,5-trichlorophenol (II): evaluation of an enzyme-linked immunosorbent assay for the analysis of water, urine, and serum samples [7].
• In addition, DEX microsomes preferentially formed 2,3,6-trichlorophenol, whereas other microsomal suspensions formed 2,4,5-trichlorophenol as the major isomer [8].
• SOC decreased the bioavailability of both chlorophenols, and the uptake rates decreased by 81% and 91% for 2,4,5-TCP and PCP, respectively, in the sediment with a SOC of 6.9% compared to those in sediment with a SOC of 0.5% [9].
• It was concluded that the major 2,4,5-trichlorophenol-detoxifying OGT in wheat shoots is most probably a flavonol-3-O-glucosytransferase [10].

Chemical compound and disease context of Nurelle

• The LBR(50) values, were practically the same in freshwater and sediments: between 1.0 and 1.6 and from 0.4 to 0.9 micromol/g wet weight for 2,4,5-TCP and PCP, respectively, demonstrating the usefulness of this method for accurate, and more comparable, measurement of toxicity of chemicals with the same mode of toxic action in varying conditions [9].

Biological context of Nurelle

• Toxicokinetics of 2,4,5-trichlorophenol and benzo(a)pyrene in the clam Pisidium amnicum: effects of seasonal temperatures and trematode parasites [11].
• Effects of 2,4,5-trichlorophenol (TCP) on life-cycle traits of the midge Chironomus riparius and the ability of the midge to evolve tolerance to TCP were assessed using a reference group and a group preexposed to TCP during three generations, both originating from the same laboratory culture [12].
• The elevated levels of hydroxypyrene, 2,4/2,5-DCP, 2,4,5-TCP and HCB in biological material may be related to the incineration of the waste [13].

Anatomical context of Nurelle

• 2,4,5-T and 2,4,5-TCP significantly changed the erythrocyte morphology [14].
• In situ Fourier Transform Infrared-Attenuated Total Reflection (FTIR-ATR) experiments with 2,4,5-trichlorophenol (TCP) adsorbed to model membranes resulted in good evidence for the formation of the TCP-heterodimer [15].
• We developed a highly sensitive method of analyzing breast milk for triclocarban (3,4,4'-trichlorocarbanilide) and eight phenolic compounds: bisphenol A (BPA), 4-tert-octylphenol (4-tOP), ortho-phenylphenol (OPP), 2,4-dichlorophenol, 2,5-dichlorophenol, 2,4,5-trichlorophenol, 2,4,6-trichlorophenol, and 2-hydroxy-4-metoxybenzophenone (BP-3) [16].

Associations of Nurelle with other chemical compounds

• An enzyme preparation with UDP-glucose-dependent O-glucosyltransferase (OGT; EC 2.4.1.-) activity toward 2,4,5-trichlorophenol has been purified 215-fold from wheat shoots [10].
• Degradation of 2,4,5-trichlorophenol and 2,3,5,6-tetrachlorophenol by combining pulse electric discharge with bioremediation [17].
• As determined by gas chromatography and mass spectrometry (GC/MS), the first stage converted 500 ppm 2,4,5-TCP to 163 ppm 2,4,5-TCP and dimethyldecene, dichloronaphthalenol, octyl acetate, and silyl esters [17].
• The median for the Germans was 3.0 micrograms/l and for the refugees between 10.8 and 14.7 micrograms/l. Also the levels of 2,4,5-TCP and 2,4,6-TCP in urine were lower in the German controls than in the men from the former USSR, Africa and Asia. CONCLUSIONS: Organochlorine compounds exist worldwide due to their extensive use [18].
• Studies on antifungal properties of phenol complexes with secondary amines. 2. Antifungal properties in vitro of the complex of 2,4,5-trichlorophenol with dicyclohexylamine [19].

Gene context of Nurelle

• 2,4,5-TCP at 100 ppm significantly decreased catalase and SOD activities [14].
• 2,4,5-T and 2,4,5-TCP did not significantly change the activity of glutathione reductase [14].
• 2,4,5-TCP decreased the level of ATP and increased the content of ADP and AMP, indicating a fall in AEC [14].

Analytical, diagnostic and therapeutic context of Nurelle

• In this paper, the effect of water and complex biological sample matrices, such as serum and urine, on the immunoassay for 2,4,5-TCP has been evaluated [7].
• METHODS: A cross sectional study of workers employed > 15 years earlier in the manufacture of 2,4,5-trichlorophenol or one of its derivatives at two United States chemical plants was conducted [20].

References