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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

AG-J-15076     2-(5-amino-7-iodo-2,4,9...

Synonyms: SureCN2043545, BSPBio_001227, KBioGR_000567, KBioSS_000567, BMK1-F1, ...
 
 
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Disease relevance of NSC113939

 

Psychiatry related information on NSC113939

 

High impact information on NSC113939

 

Biological context of NSC113939

 

Anatomical context of NSC113939

  • Further experiments using an inhibitor of either protein kinases (5-iodotubercidin) or protein phosphatases (microcystin) in isolated hepatocytes indicated that Glc-6-P does not affect glycogen-synthase kinase activity but enhances the glycogen-synthase phosphatase reaction [15].
  • 5-Iodotubercidin, a non-competitive inhibitor (Kis = 9 nM, Ku = 20 nM) of adenosine kinase, prevented the above effects of c9Ado on lymphocyte function, c9ATP formation, and ATP levels [16].
  • Inhibition of adenosine kinase (AK) with 5-iodotubercidin lowers the proliferation potential of T cells to the level observed for insulin-deprived cells [17].
  • Unanesthetized gerbils were subjected to a 5 min period of bilateral carotid artery occlusion and then maintained in an environmental chamber at 30 degrees C for 5 hr to counteract the hypothermia-inducing action of 5-iodotubercidin [4].
 

Associations of NSC113939 with other chemical compounds

 

Gene context of NSC113939

 

Analytical, diagnostic and therapeutic context of NSC113939

References

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