Chemical Compound Review:
CHEMBL351464 3-amino-1-hydroxy-pyrrolidin- 2-one
Synonyms:
SureCN253915, HA-966, AG-G-77750, AG-K-62199, ANW-56672, ...
- Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors. Widdowson, P.S., Gyte, A.J., Upton, R., Wyatt, I. Brain Res. (1996)
- HA-966 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces N-methyl-D-aspartate (NMDA)-mediated brain damage. McDonald, J.W., Uckele, J., Silverstein, F.S., Johnston, M.V. Neurosci. Lett. (1989)
- Neuroprotective effects of the strychnine-insensitive glycine site NMDA antagonist (R)-HA-966 in an experimental model of Parkinson's disease. Kanthasamy, A.G., Kanthasamy, A., Matsumoto, R.R., Vu, T.Q., Truong, D.D. Brain Res. (1997)
- Comparative anterograde amnestic and anticonvulsant effects of two types of NMDA receptor antagonists: MK-801 and HA-966. Xu, X., Klinger, P., Davis, R. Psychopharmacology (Berl.) (1995)
- Different stereoselectivity of the enantiomers of HA-966 (3-amino-1-hydroxy-2-pyrrolidinone) for neuroprotective and anticonvulsant actions in vivo. Vartanian, M.G., Taylor, C.P. Neurosci. Lett. (1991)
- The glycine/NMDA receptor antagonist HA-966 impairs visual recognition memory in rhesus monkeys. Matsuoka, N., Aigner, T.G. Brain Res. (1996)
- Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative. Singh, L., Donald, A.E., Foster, A.C., Hutson, P.H., Iversen, L.L., Iversen, S.D., Kemp, J.A., Leeson, P.D., Marshall, G.R., Oles, R.J. Proc. Natl. Acad. Sci. U.S.A. (1990)
- HA-966 antagonizes N-methyl-D-aspartate receptors through a selective interaction with the glycine modulatory site. Foster, A.C., Kemp, J.A. J. Neurosci. (1989)
- Different modes of action of 3-amino-1-hydroxy-2-pyrrolidone (HA-966) and 7-chlorokynurenic acid in the modulation of N-methyl-D-aspartate-sensitive glutamate receptors. Danysz, W., Fadda, E., Wroblewski, J.T., Costa, E. Mol. Pharmacol. (1989)
- Semicircadian rhythm of dopamine release in the mediobasal hypothalamus in awake rats during pseudopregnancy: evidence that a thyrotropin-releasing hormone analogue stimulates dopamine release and thereby inhibits prolactin secretion. Timmerman, W., Poelman, R.T., Westerink, B.H., Schuiling, G.A. Neuroendocrinology (1995)
- Anticonvulsant agents, dizocilpine maleate, enadoline and HA 966 have different effects on N-methyl-DL-aspartate-induced immediate early gene induction in mice. Woodburn, V.L., Oles, R., Poat, J., Woodruff, G.N., Hughes, J. Neuroscience (1993)
- A putative cytoprotective receptor in the kidney: relation to the neuronal strychnine-sensitive glycine receptor. Miller, G.W., Schnellmann, R.G. Life Sci. (1994)
- Selective depression of the spinal polysynaptic reflex by the NMDA receptor antagonists in an isolated spinal cord in vitro. Maruoka, Y., Ohno, Y., Tanaka, H., Yasuda, H., Ohtani, K., Sakamoto, H., Kawabe, A., Tamamura, C., Nakamura, M. Gen. Pharmacol. (1997)
- Biochemical and behavioral anxiolytic-like effects of R(+)HA-966 at the level of the ventral tegmental area in rats. Morrow, B.A., Elsworth, J.D., Zito, C., Roth, R.H. Psychopharmacology (Berl.) (1999)
- Interference with visual memory in rats following infusion of the functional NMDA receptor antagonist, HA-966, into temporal regions. Myhrer, T., Andersen, J.M. Eur. J. Pharmacol. (2001)
- Mg2+-like selective antagonism of excitatory amino acid-induced responses by alpha, epsilon-diaminopimelic acid, D-alpha-aminoadipate and HA-966 in isolated spinal cord of frog and immature rat. Evans, R.H., Francis, A.A., Watkins, J.C. Brain Res. (1978)
- GV 150526A, 7-Cl-kynurenic acid and HA 966 antagonize the glycine enhancement of N-methyl-D-aspartate-induced [3H]noradrenaline and [3H]dopamine release. Mennini, T., Mancini, L., Reggiani, A., Trist, D. Eur. J. Pharmacol. (1997)
- Antinociceptive effects of NMDA and non-NMDA receptor antagonists in the tail flick test in mice. Lutfy, K., Cai, S.X., Woodward, R.M., Weber, E. Pain (1997)
- Central regulation of adrenal tyrosine hydroxylase: interaction between dopamine and GABA systems. Gabor, R., Regunathan, S., Sourkes, T.L. Neuropharmacology (1989)
- Facilitation of dopamine D1 receptor- but not dopamine D1/D2 receptor-dependent locomotion by glutamate antagonists in the reserpine-treated mouse. Starr, M.S., Starr, B.S. Eur. J. Pharmacol. (1993)
- Competitive and uncompetitive N-methyl-D-aspartate antagonist discriminations in pigeons: CGS 19755 and phencyclidine. Baron, S.P., Woods, J.H. Psychopharmacology (Berl.) (1995)
- Opposite effects of glutamate antagonists and antiparkinsonian drugs on the activities of DOPA decarboxylase and 5-HTP decarboxylase in the rat brain. Fisher, A., Starr, M.S. Brain Res. (2000)
- Anxiolytic effect of glycine antagonists microinjected into the dorsal periaqueductal grey. Matheus, M.G., Nogueira, R.L., Carobrez, A.P., Graeff, F.G., Guimarães, F.S. Psychopharmacology (Berl.) (1994)
- FK960 [N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate], a novel potential antidementia drug, restores the regional cerebral blood flow response abolished by scopolamine but not by HA-966: a positron emission tomography study with unanesthetized rhesus monkeys. Tsukada, H., Yamazaki, S., Noda, A., Inoue, T., Matsuoka, N., Kakiuchi, T., Nishiyama, S., Nishimura, S. Brain Res. (1999)
- Pharmacological agents, hippocampal EEG, and anticonvulsant effects on soman-induced seizures in rats. Myhrer, T., Skymoen, L.R., Aas, P. Neurotoxicology (2003)