Disease relevance of Tau-methylhistamine

• The fall in FEV1 was correlated with the degree of bronchial hyperreactivity to histamine, but no significant correlation was found with the increase in urinary N tau-methylhistamine excretion [1].
• Urinary N tau-methylhistamine, a unique histamine metabolite, was determined in 29 patients with bronchial asthma before and after inhalation of a control solution on 1 day and before and after allergen inhalation on another day [1].
• 2-Methylhistamine caused a similar biphasic response, while 3-methylhistamine had no effect on body temperature and 4-methylhistamine produced a delayed hyperthermia [2].
• Clear cases of mastocytosis can be diagnosed, using the RIA-kit, but for a more precise N tau-methylhistamine value GCMS analyses will remain necessary [3].

High impact information on Tau-methylhistamine

• BACKGROUND: Histamine is metabolized mainly by histamine N-methyltransferase (HMT) to N tau-methylhistamine in human nasal mucosa [4].
• After prolonged (60 min) incubation, histamine metabolites detected in the cells presented 78% of the chromatogram radioactivity and consisted of N tau-methylhistamine and N tau-methylimidazole acetic acid [5].
• In both glomeruli and tubules, the diamine oxidase inhibitor, amino-guanidine, abolished the production of acid metabolites while amodiaquine and pyrilamine, inhibitors of the methylation pathway, markedly reduced the production of N tau-methylhistamine [6].
• A method for the simultaneous determinations of histamine and its metabolite N tau-methylhistamine by HPLC-chemiluminescence coupled with immobilized diamine oxidase was developed [7].
• To investigate this we have measured the changes in forced expiratory volume in one second (FEV1), plasma histamine and urinary N tau-methylhistamine, in 10 asthmatics following inhaled allergen [8].

Anatomical context of Tau-methylhistamine

• The provenience of N tau-methylhistamine in mast cells is discussed [9].
• Hi released from isolated basophils was converted enzymically to N-tau-methylhistamine (NMH) which was then measured by a very sensitive RIA [10].
• In both species submandibular gland was among the richest tissues in N tau-methylhistamine content [9].
• The only metabolite that was detected and extracted from cytosol has been identified by TLC to N tau-methylhistamine [11].
• H3-receptor antagonist activity in the central nervous system (CNS) was detected for most compounds in the in vivo H3-receptor assay based upon measurement of brain N tau-methylhistamine levels after p.o. administration to mice [12].

Associations of Tau-methylhistamine with other chemical compounds

• Both histamine and N tau-methylhistamine peak heights increased significantly and selectively after treatment with pargyline [13].
• Carcinine was identified in several tissue of the rat, guinea pig, mouse and human, and was then shown to be metabolically related in vivo to histamine, histidine, carnosine and 3-methylhistamine through radioisotopic labeling [14].
• Effect of continuous administration of nicotine on urinary histamine and N tau-methylhistamine levels in the guinea pig [15].
• Release of PGD2 was not accompanied by a release of histamine which was assessed by quantification of plasma levels of the histamine metabolite, N tau-methylhistamine [16].
• When either endpoint was reached the animals were sacrificed and their hearts were removed for tissue analyses of histidine, histamine, 3-methylhistamine, and carnosine via high-pressure liquid chromatography [17].

Gene context of Tau-methylhistamine

• Addition of an MAO inhibitor such as pargyline to tissue preparations can increase the HNMT activity assayed --presumably as a result of inhibition of N tau-methylhistamine metabolism by MAO [18].
• The differential reaction of histamine and N tau-methylhistamine with Pauly's diazo reagent: application to assay of histamine N-methyltransferase activity [19].
• No difference was found in N tau-methylhistamine in BAF between patients with LAR and controls [20].
• Imidazole, methylimidazoles, N-acetylimidazole, histamine and N tau-methylhistamine are relatively potent inhibitors of mammalian diamine oxidase showing no influence on plant enzymes [21].

Analytical, diagnostic and therapeutic context of Tau-methylhistamine

• Determination of N tau-methylhistamine in urine by gas chromatography using nitrogen-phosphorus detection [22].
• The product of the reaction was identified as N tau-methylhistamine by high performance liquid chromatography [23].
• In comparison with plasma histamine, the determination of plasma N tau-methylhistamine is less hampered by artefacts caused by blood collection and plasma preparation [24].

References