The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

VITAMIN E     2,5,7,8-tetramethyl-2- (4,8,12...

Synonyms: Denamone, Viteolin, Esorb, Phytogermine, Waynecomycin, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of VITAMIN E

  • During a Phase I study of intravenous vitamin E-free alcohol (all-rac-alpha-tocopherol or Ephynal) in patients with neuroblastoma, we noticed a bleeding diathesis in two patients receiving 2300 mg/m2 daily for four or more days in succession [1].
  • In infants with birth weight less than 1 000 g treatment with 25 mg Ephynal/day was found to increase serum-alpha-tocopherol on day seven to 46.9 +/- 12.3 mumol/l (mean +/- SD) [2].

Psychiatry related information on VITAMIN E


High impact information on VITAMIN E


Biological context of VITAMIN E


Anatomical context of VITAMIN E


Associations of VITAMIN E with other chemical compounds


  1. The effect of intravenous vitamin E and menadiol sodium diphosphate on vitamin K dependent clotting factors. Helson, L. Thromb. Res. (1984) [Pubmed]
  2. Intestinal absorption of vitamin E in low birth weight infants. Jansson, L., Lindroth, M., Työppönen, J. Acta paediatrica Scandinavica. (1984) [Pubmed]
  3. Lipid peroxidation and antioxidants in erythrocyte membranes of full-term and preterm newborns. Huertas, J.R., Palomino, N., Ochoa, J.J., Quiles, J.L., Ramírez-Tortosa, M.C., Battino, M., Robles, R., Mataix, J. Biofactors (1998) [Pubmed]
  4. Stopped-flow investigation of the reaction of vitamin C with tocopheroxyl radical in aqueous triton X-100 micellar solutions. The structure-activity relationship of the regeneration reaction of tocopherol by vitamin C. Mukai, K., Nishimura, M., Kikuchi, S. J. Biol. Chem. (1991) [Pubmed]
  5. Mitochondrial electron transport-linked tocopheroxyl radical reduction. Maguire, J.J., Wilson, D.S., Packer, L. J. Biol. Chem. (1989) [Pubmed]
  6. Tocopheroxyl radical persistence and tocopherol consumption in liposomes and in vitamin E-enriched rat liver mitochondria and microsomes. Mehlhorn, R.J., Sumida, S., Packer, L. J. Biol. Chem. (1989) [Pubmed]
  7. Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids. Sies, H., Stahl, W., Sundquist, A.R. Ann. N. Y. Acad. Sci. (1992) [Pubmed]
  8. Independent antioxidant action of vitamins E and C in cultured rat hepatocytes intoxicated with allyl alcohol. Glascott, P.A., Gilfor, E., Serroni, A., Farber, J.L. Biochem. Pharmacol. (1996) [Pubmed]
  9. alpha-Tocopherol transfer protein expression in rat liver exposed to hyperoxia. Ban, R., Takitani, K., Kim, H.S., Murata, T., Morinobu, T., Ogihara, T., Tamai, H. Free Radic. Res. (2002) [Pubmed]
  10. Lipoperoxidation damage of spermatozoa polyunsaturated fatty acids (PUFA): scavenger mechanisms and possible scavenger therapies. Lenzi, A., Gandini, L., Picardo, M., Tramer, F., Sandri, G., Panfili, E. Front. Biosci. (2000) [Pubmed]
  11. Alpha-tocopherol supplementation does not affect monocyte endothelial adhesion or C-reactive protein levels but reduces soluble vascular adhesion molecule-1 in the plasma of healthy subjects. Woollard, K.J., Rayment, S.J., Bevan, R., Shaw, J.A., Lunec, J., Griffiths, H.R. Redox Rep. (2006) [Pubmed]
  12. Sparing effect of procyanidins from Vitis vinifera on vitamin E: in vitro studies. Maffei Facino, R., Carini, M., Aldini, G., Calloni, M.T., Bombardelli, E., Morazzoni, P. Planta Med. (1998) [Pubmed]
  13. Active oxygen chemistry within the liposomal bilayer. Part III: Locating Vitamin E, ubiquinol and ubiquinone and their derivatives in the lipid bilayer. Afri, M., Ehrenberg, B., Talmon, Y., Schmidt, J., Cohen, Y., Frimer, A.A. Chem. Phys. Lipids (2004) [Pubmed]
  14. Preventive care for patients with chronic illness. Multivitamin use in patients with cystic fibrosis. Borowitz, D., Wegman, T., Harris, M. Clinical pediatrics. (1994) [Pubmed]
  15. Prolonged alpha-tocopherol deficiency decreases oxidative stress and unmasks alpha-tocopherol-dependent regulation of mitochondrial function in the brain. Cuddihy, S.L., Ali, S.S., Musiek, E.S., Lucero, J., Kopp, S.J., Morrow, J.D., Dugan, L.L. J. Biol. Chem. (2008) [Pubmed]
  16. 7-ketocholesterol incorporation into sphingolipid/cholesterol-enriched (lipid raft) domains is impaired by vitamin E: a specific role for alpha-tocopherol with consequences on cell death. Royer, M.C., Lemaire-Ewing, S., Desrumaux, C., Monier, S., Pais de Barros, J.P., Athias, A., Néel, D., Lagrost, L. J. Biol. Chem. (2009) [Pubmed]
WikiGenes - Universities