The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

AG-K-69439     2- (3,7,11,15,19,23,27,31,35,39. ..

Synonyms: AC1L1AUK, CTK6J3655
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of ubiquinol-10

 

Psychiatry related information on ubiquinol-10

 

High impact information on ubiquinol-10

 

Chemical compound and disease context of ubiquinol-10

 

Biological context of ubiquinol-10

 

Anatomical context of ubiquinol-10

 

Associations of ubiquinol-10 with other chemical compounds

 

Gene context of ubiquinol-10

  • Lag time for in vitro LDL oxidation positively correlated with ubiquinol-10 levels (p = 0.008), but not with other antioxidants studied or beta(2)GPI [19].
  • Coenzyme Q(10) (CoQ(10)) in its reduced form, ubiquinol-10, effectively inhibits lipoprotein oxidation in vitro and in vivo; CoQ(10) supplements also inhibit atherosclerosis in apolipoprotein E gene knockout (apoE-/-) mice [20].
  • A significant correlation (r = 0.328) also occurred between ubiquinol-10 concentration and citrate synthase activity [21].
  • The concentration of five lipid-soluble antioxidants (gamma- and alpha-tocopherol, lycopene, beta-carotene and ubiquinol-10) was measured in plasma and very low-density, low-density and high-density lipoproteins (VLDL, LDL and HDL) isolated from young healthy normo- cholesterolemic subjects [22].
 

Analytical, diagnostic and therapeutic context of ubiquinol-10

References

  1. Plasma ubiquinol-10 is decreased in patients with hyperlipidaemia. Kontush, A., Reich, A., Baum, K., Spranger, T., Finckh, B., Kohlschütter, A., Beisiegel, U. Atherosclerosis (1997) [Pubmed]
  2. Plasma ubiquinol-10 as a marker for disease: is the assay worthwhile? Kontush, A., Schippling, S., Spranger, T., Beisiegel, U. Biofactors (1999) [Pubmed]
  3. Investigation of ubiquinol formation in isolated photosynthetic reaction centers by rapid-scan Fourier transform IR spectroscopy. Mezzetti, A., Leibl, W. Eur. Biophys. J. (2005) [Pubmed]
  4. Effects of fenofibrate therapy on plasma ubiquinol-10 and ubiquinone-10 levels in Japanese patients with hyperlipidemia and type 2 diabetes mellitus. Asano, A., Kobayashi, J., Murase, Y., Nohara, A., Kawashiri, M.A., Inazu, A., Shimizu, M., Mabuchi, H. Pharmacotherapy (2006) [Pubmed]
  5. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Stocker, R., Bowry, V.W., Frei, B. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  6. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Frei, B., Kim, M.C., Ames, B.N. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  7. The oxidation of blood plasma and low density lipoprotein components by chemically generated singlet oxygen. Wagner, J.R., Motchnik, P.A., Stocker, R., Sies, H., Ames, B.N. J. Biol. Chem. (1993) [Pubmed]
  8. Coenzyme Q blocks biochemical but not receptor-mediated apoptosis by increasing mitochondrial antioxidant protection. Alleva, R., Tomasetti, M., Andera, L., Gellert, N., Borghi, B., Weber, C., Murphy, M.P., Neuzil, J. FEBS Lett. (2001) [Pubmed]
  9. The participation of nitric oxide in cell free- and its restriction of macrophage-mediated oxidation of low-density lipoprotein. Jessup, W., Mohr, D., Gieseg, S.P., Dean, R.T., Stocker, R. Biochim. Biophys. Acta (1992) [Pubmed]
  10. Structure-Activity Relationship of the Free-Radical-Scavenging Reaction by Vitamin E (alpha-, beta-, gamma-, delta-Tocopherols) and Ubiquinol-10: pH Dependence of the Reaction Rates. Mukai, K., Tokunaga, A., Itoh, S., Kanesaki, Y., Ohara, K., Nagaoka, S., Abe, K. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical (2007) [Pubmed]
  11. Alcohol-induced pancreatic oxidative stress: protection by phospholipid repletion. Aleynik, S.I., Leo, M.A., Aleynik, M.K., Lieber, C.S. Free Radic. Biol. Med. (1999) [Pubmed]
  12. Evaluation of antioxidants, protein, and lipid oxidation products in blood from sporadic amyotrophic lateral sclerosis patients. Oteiza, P.I., Uchitel, O.D., Carrasquedo, F., Dubrovski, A.L., Roma, J.C., Fraga, C.G. Neurochem. Res. (1997) [Pubmed]
  13. Ubiquinol: a potential biomarker for tissue energy requirements and oxidative stress. Miles, L., Miles, M.V., Tang, P.H., Horn, P.S., Quinlan, J.G., Wong, B., Wenisch, A., Bove, K.E. Clin. Chim. Acta (2005) [Pubmed]
  14. The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress. Xia, L., Nordman, T., Olsson, J.M., Damdimopoulos, A., Björkhem-Bergman, L., Nalvarte, I., Eriksson, L.C., Arnér, E.S., Spyrou, G., Björnstedt, M. J. Biol. Chem. (2003) [Pubmed]
  15. Effect of antioxidants on oxidative modification of LDL. Esterbauer, H., Puhl, H., Dieber-Rotheneder, M., Waeg, G., Rabl, H. Ann. Med. (1991) [Pubmed]
  16. Plasma and LDL levels of major lipophilic antioxidants are similar in patients with advanced atherosclerosis and age-matched controls. Cleary, J., Mohr, D., Adams, M.R., Celermajer, D.S., Stocker, R. Free Radic. Res. (1997) [Pubmed]
  17. How different constituents of low density lipoprotein determine its oxidizability by copper: a correlational approach. Kontush, A., Hübner, C., Finckh, B., Kohlschütter, A., Beisiegel, U. Free Radic. Res. (1996) [Pubmed]
  18. Fluorescence properties of plastoquinol, ubiquinol and alpha-tocopherol quinol in solution and liposome membranes. Kruk, J., Strzałka, K., Leblanc, R.M. J. Photochem. Photobiol. B, Biol. (1993) [Pubmed]
  19. Role of beta2-glycoprotein I, LDL-, and antioxidant levels in hypercholesterolemic elderly subjects. Gomes, L.F., Alves, A.F., Sevanian, A., Peres, C.d.e. .A., Cendoroglo, M.S., de Mello-Almada, C., Quirino, L.M., Ramos, L.R., Junqueira, V.B. Antioxid. Redox Signal. (2004) [Pubmed]
  20. Coenzyme Q(10) supplementation inhibits aortic lipid oxidation but fails to attenuate intimal thickening in balloon-injured New Zealand white rabbits. Choy, K.J., Deng, Y.M., Hou, J.Y., Wu, B., Lau, A., Witting, P.K., Stocker, R. Free Radic. Biol. Med. (2003) [Pubmed]
  21. Muscle coenzyme Q: a potential test for mitochondrial activity and redox status. Miles, L., Miles, M.V., Tang, P.H., Horn, P.S., Wong, B.L., DeGrauw, T.J., Morehart, P.J., Bove, K.E. Pediatric neurology. (2005) [Pubmed]
  22. Distribution of lipid-soluble antioxidants in lipoproteins from healthy subjects. I. Correlation with plasma antioxidant levels and composition of lipoproteins. Perugini, C., Bagnati, M., Cau, C., Bordone, R., Zoppis, E., Paffoni, P., Re, R., Albano, E., Bellomo, G. Pharmacol. Res. (2000) [Pubmed]
  23. The interaction of coenzyme Q with phosphatidylethanolamine membranes. Gómez-Fernández, J.C., Llamas, M.A., Aranda, F.J. Eur. J. Biochem. (1999) [Pubmed]
  24. Automated high-performance liquid chromatographic method with precolumn reduction for the determination of ubiquinol and ubiquinone in human plasma. Wang, Q., Lee, B.L., Ong, C.N. J. Chromatogr. B Biomed. Sci. Appl. (1999) [Pubmed]
  25. The protective role of ubiquinol-10 against formation of lipid hydroperoxides in human seminal fluid. Alleva, R., Scararmucci, A., Mantero, F., Bompadre, S., Leoni, L., Littarru, G.P. Mol. Aspects Med. (1997) [Pubmed]
 
WikiGenes - Universities